diff --git a/hw/i386/pc.c b/hw/i386/pc.c
index 56d8c179ea..1c5c9e17c6 100644
--- a/hw/i386/pc.c
+++ b/hw/i386/pc.c
@@ -891,6 +891,40 @@ static hwaddr pc_max_used_gpa(PCMachineState *pcms, uint64_t pci_hole64_size)
     return pc_pci_hole64_start() + pci_hole64_size - 1;
 }
 
+/*
+ * AMD systems with an IOMMU have an additional hole close to the
+ * 1Tb, which are special GPAs that cannot be DMA mapped. Depending
+ * on kernel version, VFIO may or may not let you DMA map those ranges.
+ * Starting Linux v5.4 we validate it, and can't create guests on AMD machines
+ * with certain memory sizes. It's also wrong to use those IOVA ranges
+ * in detriment of leading to IOMMU INVALID_DEVICE_REQUEST or worse.
+ * The ranges reserved for Hyper-Transport are:
+ *
+ * FD_0000_0000h - FF_FFFF_FFFFh
+ *
+ * The ranges represent the following:
+ *
+ * Base Address   Top Address  Use
+ *
+ * FD_0000_0000h FD_F7FF_FFFFh Reserved interrupt address space
+ * FD_F800_0000h FD_F8FF_FFFFh Interrupt/EOI IntCtl
+ * FD_F900_0000h FD_F90F_FFFFh Legacy PIC IACK
+ * FD_F910_0000h FD_F91F_FFFFh System Management
+ * FD_F920_0000h FD_FAFF_FFFFh Reserved Page Tables
+ * FD_FB00_0000h FD_FBFF_FFFFh Address Translation
+ * FD_FC00_0000h FD_FDFF_FFFFh I/O Space
+ * FD_FE00_0000h FD_FFFF_FFFFh Configuration
+ * FE_0000_0000h FE_1FFF_FFFFh Extended Configuration/Device Messages
+ * FE_2000_0000h FF_FFFF_FFFFh Reserved
+ *
+ * See AMD IOMMU spec, section 2.1.2 "IOMMU Logical Topology",
+ * Table 3: Special Address Controls (GPA) for more information.
+ */
+#define AMD_HT_START         0xfd00000000UL
+#define AMD_HT_END           0xffffffffffUL
+#define AMD_ABOVE_1TB_START  (AMD_HT_END + 1)
+#define AMD_HT_SIZE          (AMD_ABOVE_1TB_START - AMD_HT_START)
+
 void pc_memory_init(PCMachineState *pcms,
                     MemoryRegion *system_memory,
                     MemoryRegion *rom_memory,
@@ -914,6 +948,26 @@ void pc_memory_init(PCMachineState *pcms,
 
     linux_boot = (machine->kernel_filename != NULL);
 
+    /*
+     * The HyperTransport range close to the 1T boundary is unique to AMD
+     * hosts with IOMMUs enabled. Restrict the ram-above-4g relocation
+     * to above 1T to AMD vCPUs only.
+     */
+    if (IS_AMD_CPU(&cpu->env)) {
+        /* Bail out if max possible address does not cross HT range */
+        if (pc_max_used_gpa(pcms, pci_hole64_size) >= AMD_HT_START) {
+            x86ms->above_4g_mem_start = AMD_ABOVE_1TB_START;
+        }
+
+        /*
+         * Advertise the HT region if address space covers the reserved
+         * region or if we relocate.
+         */
+        if (cpu->phys_bits >= 40) {
+            e820_add_entry(AMD_HT_START, AMD_HT_SIZE, E820_RESERVED);
+        }
+    }
+
     /*
      * phys-bits is required to be appropriately configured
      * to make sure max used GPA is reachable.