diff --git a/CMakeLists.txt b/CMakeLists.txt
index a0c35776..c624a9ed 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -40,12 +40,15 @@ endif()
 set(ASM_DEFAULT OFF)
 
 # use ccache if available, and not already enabled on the command line
-if(NOT CMAKE_CXX_COMPILER_LAUNCHER AND NOT CMAKE_C_COMPILER_LAUNCHER)
-    find_program(CCACHE_FOUND ccache)
-    if(CCACHE_FOUND)
-        set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ccache)
-        set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ccache)
-    endif(CCACHE_FOUND)
+# but not with ninja and msys ccache on msys2
+if(NOT (WIN32 AND (NOT $ENV{MSYSTEM} STREQUAL "") AND CMAKE_GENERATOR STREQUAL Ninja))
+    if(NOT CMAKE_CXX_COMPILER_LAUNCHER AND NOT CMAKE_C_COMPILER_LAUNCHER)
+        find_program(CCACHE_FOUND ccache)
+        if(CCACHE_FOUND)
+            set_property(GLOBAL PROPERTY RULE_LAUNCH_COMPILE ccache)
+            set_property(GLOBAL PROPERTY RULE_LAUNCH_LINK ccache)
+        endif(CCACHE_FOUND)
+    endif()
 endif()
 
 if(NOT CMAKE_SYSTEM_PROCESSOR)