diff --git a/rpcs3/Emu/RSX/GL/GLGSRender.cpp b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
index 57e233bb67..e91f71dab6 100644
--- a/rpcs3/Emu/RSX/GL/GLGSRender.cpp
+++ b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
@@ -31,7 +31,7 @@ GLGSRender::GLGSRender() : GSRender()
 {
 	m_shaders_cache = std::make_unique<gl::shader_cache>(m_prog_buffer, "opengl", "v1.6");
 
-	if (g_cfg.video.disable_vertex_cache)
+	if (g_cfg.video.disable_vertex_cache || g_cfg.video.multithreaded_rsx)
 		m_vertex_cache = std::make_unique<gl::null_vertex_cache>();
 	else
 		m_vertex_cache = std::make_unique<gl::weak_vertex_cache>();
diff --git a/rpcs3/Emu/RSX/VK/VKGSRender.cpp b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
index cf85cbf507..cdc66f5ae6 100644
--- a/rpcs3/Emu/RSX/VK/VKGSRender.cpp
+++ b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
@@ -534,7 +534,7 @@ VKGSRender::VKGSRender() : GSRender()
 
 	m_prog_buffer = std::make_unique<VKProgramBuffer>();
 
-	if (g_cfg.video.disable_vertex_cache)
+	if (g_cfg.video.disable_vertex_cache || g_cfg.video.multithreaded_rsx)
 		m_vertex_cache = std::make_unique<vk::null_vertex_cache>();
 	else
 		m_vertex_cache = std::make_unique<vk::weak_vertex_cache>();