diff --git a/common/RedtapeWindows.h b/common/RedtapeWindows.h
index d9474bb186..6d83ce7c9c 100644
--- a/common/RedtapeWindows.h
+++ b/common/RedtapeWindows.h
@@ -24,8 +24,14 @@
 #define NOMINMAX
 #endif
 
-// Win8.1 is our minimum at the moment.
+// Qt build requires Windows 10+, WX Windows 8.1+.
+#ifndef _WIN32_WINNT
+#ifdef PCSX2_CORE
+#define _WIN32_WINNT 0x0A00 // Windows 10
+#else
 #define _WIN32_WINNT 0x0603 // Windows 8.1
+#endif
+#endif
 
 #include <windows.h>
 #include <VersionHelpers.h>
diff --git a/common/vsprops/BaseProperties.props b/common/vsprops/BaseProperties.props
index eec343552b..fd701baf63 100644
--- a/common/vsprops/BaseProperties.props
+++ b/common/vsprops/BaseProperties.props
@@ -11,7 +11,7 @@
     <ClCompile>
       <IntrinsicFunctions>true</IntrinsicFunctions>
       <AdditionalIncludeDirectories>$(SolutionDir);%(AdditionalIncludeDirectories)</AdditionalIncludeDirectories>
-      <PreprocessorDefinitions>__WIN32__;WIN32;_WINDOWS;_CRT_SECURE_NO_WARNINGS;_CRT_SECURE_NO_DEPRECATE;WINVER=0x0603;_WIN32_WINNT=0x0603;%(PreprocessorDefinitions)</PreprocessorDefinitions>
+      <PreprocessorDefinitions>__WIN32__;WIN32;_WINDOWS;_CRT_SECURE_NO_WARNINGS;_CRT_SECURE_NO_DEPRECATE;WINVER=0x0A00;_WIN32_WINNT=0x0A00;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <StructMemberAlignment>16Bytes</StructMemberAlignment>
       <FunctionLevelLinking>true</FunctionLevelLinking>
       <RuntimeTypeInfo>false</RuntimeTypeInfo>
diff --git a/pcsx2-qt/pcsx2-qt.vcxproj b/pcsx2-qt/pcsx2-qt.vcxproj
index 9f11f7bf6c..1e3c584711 100644
--- a/pcsx2-qt/pcsx2-qt.vcxproj
+++ b/pcsx2-qt/pcsx2-qt.vcxproj
@@ -74,7 +74,7 @@
       <SubSystem>Windows</SubSystem>
       <LargeAddressAware>Yes</LargeAddressAware>
       <AdditionalDependencies>comctl32.lib;ws2_32.lib;shlwapi.lib;winmm.lib;rpcrt4.lib;iphlpapi.lib;dsound.lib;%(AdditionalDependencies)</AdditionalDependencies>
-      <AdditionalDependencies>dxguid.lib;dinput8.lib;hid.lib;PowrProf.lib;d3dcompiler.lib;d3d11.lib;dxgi.lib;strmiids.lib;opengl32.lib;comsuppw.lib;%(AdditionalDependencies)</AdditionalDependencies>
+      <AdditionalDependencies>dxguid.lib;dinput8.lib;hid.lib;PowrProf.lib;d3dcompiler.lib;d3d11.lib;dxgi.lib;strmiids.lib;opengl32.lib;comsuppw.lib;OneCore.lib;%(AdditionalDependencies)</AdditionalDependencies>
       <AdditionalDependencies>$(QtEntryPointLib);%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
diff --git a/pcsx2/CMakeLists.txt b/pcsx2/CMakeLists.txt
index 43a6bc2b43..cfa1a72c46 100644
--- a/pcsx2/CMakeLists.txt
+++ b/pcsx2/CMakeLists.txt
@@ -1649,7 +1649,11 @@ if(WIN32)
 		opengl32.lib
 		comsuppw.lib
 	)
-	if(NOT PCSX2_CORE)
+	if(PCSX2_CORE)
+		target_link_libraries(PCSX2_FLAGS INTERFACE
+			OneCore.lib
+		)
+	else()
 		target_link_libraries(PCSX2_FLAGS INTERFACE
 			pthreads4w
 		)
diff --git a/pcsx2/SPU2/Windows/SndOut_XAudio2.cpp b/pcsx2/SPU2/Windows/SndOut_XAudio2.cpp
index f4c91ad432..a83e62f50a 100644
--- a/pcsx2/SPU2/Windows/SndOut_XAudio2.cpp
+++ b/pcsx2/SPU2/Windows/SndOut_XAudio2.cpp
@@ -20,7 +20,6 @@
 #endif
 #include "common/Console.h"
 
-#include <xaudio2.h>
 #include <memory>
 #include <sstream>
 #include <stdexcept>
@@ -30,6 +29,17 @@
 #include <wil/resource.h>
 #include <wil/win32_helpers.h>
 
+// We set _WIN32_WINNT to Win10, which means that xaudio2.h tries to use
+// the Windows 10 version. For wx, we still need to support Win8, so we
+// cheekily redefine _WIN32_WINNT before xaudio2.h is included, so that
+// it uses the older DLL.
+#ifndef PCSX2_CORE
+#undef _WIN32_WINNT
+#define _WIN32_WINNT _WIN32_WINNT_WIN8
+#endif
+
+#include <xaudio2.h>
+
 //#define XAUDIO2_DEBUG
 
 class XAudio2Mod final : public SndOutModule
diff --git a/pcsx2/pcsx2core.vcxproj b/pcsx2/pcsx2core.vcxproj
index d2f7e377a6..4c023d5f9e 100644
--- a/pcsx2/pcsx2core.vcxproj
+++ b/pcsx2/pcsx2core.vcxproj
@@ -75,7 +75,7 @@
     <Link>
       <LargeAddressAware>Yes</LargeAddressAware>
       <AdditionalDependencies>comctl32.lib;ws2_32.lib;shlwapi.lib;winmm.lib;rpcrt4.lib;iphlpapi.lib;dsound.lib;%(AdditionalDependencies)</AdditionalDependencies>
-      <AdditionalDependencies>dxguid.lib;dinput8.lib;hid.lib;PowrProf.lib;d3dcompiler.lib;d3d11.lib;dxgi.lib;strmiids.lib;opengl32.lib;comsuppw.lib;%(AdditionalDependencies)</AdditionalDependencies>
+      <AdditionalDependencies>dxguid.lib;dinput8.lib;hid.lib;PowrProf.lib;d3dcompiler.lib;d3d11.lib;dxgi.lib;strmiids.lib;opengl32.lib;comsuppw.lib;OneCore.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
   <ItemGroup>