diff --git a/pcsx2/Config.h b/pcsx2/Config.h
index bedd6cbc93..9bca524c27 100644
--- a/pcsx2/Config.h
+++ b/pcsx2/Config.h
@@ -697,7 +697,6 @@ struct Pcsx2Config
 					UserHacks_MergePPSprite : 1,
 					UserHacks_WildHack : 1,
 					UserHacks_NativePaletteDraw : 1,
-					UserHacks_TargetPartialInvalidation : 1,
 					UserHacks_EstimateTextureRegion : 1,
 					FXAA : 1,
 					ShadeBoost : 1,
diff --git a/pcsx2/Pcsx2Config.cpp b/pcsx2/Pcsx2Config.cpp
index 87b67e80e1..505be2afbf 100644
--- a/pcsx2/Pcsx2Config.cpp
+++ b/pcsx2/Pcsx2Config.cpp
@@ -762,7 +762,6 @@ void Pcsx2Config::GSOptions::LoadSave(SettingsWrapper& wrap)
 	GSSettingIntEnumEx(UserHacks_BilinearHack, "UserHacks_BilinearHack");
 	GSSettingBoolEx(UserHacks_NativePaletteDraw, "UserHacks_NativePaletteDraw");
 	GSSettingIntEnumEx(UserHacks_TextureInsideRt, "UserHacks_TextureInsideRt");
-	GSSettingBoolEx(UserHacks_TargetPartialInvalidation, "UserHacks_TargetPartialInvalidation");
 	GSSettingBoolEx(UserHacks_EstimateTextureRegion, "UserHacks_EstimateTextureRegion");
 	GSSettingBoolEx(FXAA, "fxaa");
 	GSSettingBool(ShadeBoost);
@@ -889,7 +888,6 @@ void Pcsx2Config::GSOptions::MaskUserHacks()
 	UserHacks_CPUFBConversion = false;
 	UserHacks_ReadTCOnClose = false;
 	UserHacks_TextureInsideRt = GSTextureInRtMode::Disabled;
-	UserHacks_TargetPartialInvalidation = false;
 	UserHacks_EstimateTextureRegion = false;
 	UserHacks_TCOffsetX = 0;
 	UserHacks_TCOffsetY = 0;