diff --git a/PCSX2_qt.sln b/PCSX2_qt.sln
index f0f732c9e0..fa7a984c3d 100644
--- a/PCSX2_qt.sln
+++ b/PCSX2_qt.sln
@@ -26,8 +26,6 @@ Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "wx30_base", "3rdparty\wxwid
 EndProject
 Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "libpng", "3rdparty\libpng\projects\vstudio\libpng\libpng.vcxproj", "{D6973076-9317-4EF2-A0B8-B7A18AC0713E}"
 EndProject
-Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "pthreads4w", "3rdparty\pthreads4w\build\pthreads4w.vcxproj", "{0FAE817D-9A32-4830-857E-81DA57246E16}"
-EndProject
 Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "baseclasses", "3rdparty\baseclasses\baseclasses.vcxproj", "{27F17499-A372-4408-8AFA-4F9F4584FBD3}"
 EndProject
 Project("{8BC9CEB8-8B4A-11D0-8D11-00A0C91BC942}") = "liblzma", "3rdparty\xz\liblzma.vcxproj", "{12728250-16EC-4DC6-94D7-E21DD88947F8}"
@@ -170,18 +168,6 @@ Global
 		{D6973076-9317-4EF2-A0B8-B7A18AC0713E}.Release AVX2|x64.Build.0 = Release|x64
 		{D6973076-9317-4EF2-A0B8-B7A18AC0713E}.Release|x64.ActiveCfg = Release|x64
 		{D6973076-9317-4EF2-A0B8-B7A18AC0713E}.Release|x64.Build.0 = Release|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Debug AVX2|x64.ActiveCfg = Debug|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Debug AVX2|x64.Build.0 = Debug|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Debug|x64.ActiveCfg = Debug|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Debug|x64.Build.0 = Debug|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Devel AVX2|x64.ActiveCfg = Devel|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Devel AVX2|x64.Build.0 = Devel|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Devel|x64.ActiveCfg = Devel|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Devel|x64.Build.0 = Devel|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Release AVX2|x64.ActiveCfg = Release|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Release AVX2|x64.Build.0 = Release|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Release|x64.ActiveCfg = Release|x64
-		{0FAE817D-9A32-4830-857E-81DA57246E16}.Release|x64.Build.0 = Release|x64
 		{27F17499-A372-4408-8AFA-4F9F4584FBD3}.Debug AVX2|x64.ActiveCfg = Debug|x64
 		{27F17499-A372-4408-8AFA-4F9F4584FBD3}.Debug AVX2|x64.Build.0 = Debug|x64
 		{27F17499-A372-4408-8AFA-4F9F4584FBD3}.Debug|x64.ActiveCfg = Debug|x64
@@ -410,7 +396,6 @@ Global
 		{01F4CE10-2CFB-41A8-B41F-E54337868A1D} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
 		{3FCC50C2-81E9-5DB2-B8D8-2129427568B1} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
 		{D6973076-9317-4EF2-A0B8-B7A18AC0713E} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
-		{0FAE817D-9A32-4830-857E-81DA57246E16} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
 		{27F17499-A372-4408-8AFA-4F9F4584FBD3} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
 		{12728250-16EC-4DC6-94D7-E21DD88947F8} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
 		{449AD25E-424A-4714-BABC-68706CDCC33B} = {78EBE642-7A4D-4EA7-86BE-5639C6646C38}
diff --git a/common/CMakeLists.txt b/common/CMakeLists.txt
index f0ac231576..ba9301db18 100644
--- a/common/CMakeLists.txt
+++ b/common/CMakeLists.txt
@@ -170,7 +170,7 @@ endif()
 if(WIN32)
 	enable_language(ASM_MASM)
 	target_sources(common PRIVATE FastJmp.asm)
-	target_link_libraries(common PUBLIC WIL::WIL D3D12MemAlloc pthreads4w Winmm.lib)
+	target_link_libraries(common PUBLIC WIL::WIL D3D12MemAlloc Winmm.lib)
 	target_sources(common PRIVATE
 		CrashHandler.cpp
 		CrashHandler.h
diff --git a/common/common.vcxproj b/common/common.vcxproj
index 50e9354df4..0e71e61899 100644
--- a/common/common.vcxproj
+++ b/common/common.vcxproj
@@ -21,7 +21,6 @@
   <ImportGroup Label="PropertySheets">
     <Import Project="vsprops\CommonLibrary.props" />
     <Import Project="vsprops\3rdpartyDeps.props" />
-    <Import Project="vsprops\pthreads.props" />
     <Import Condition="$(Configuration.Contains(Debug))" Project="vsprops\CodeGen_Debug.props" />
     <Import Condition="$(Configuration.Contains(Devel))" Project="vsprops\CodeGen_Devel.props" />
     <Import Condition="$(Configuration.Contains(Release))" Project="vsprops\CodeGen_Release.props" />
@@ -211,9 +210,6 @@
     <ProjectReference Include="..\3rdparty\glslang\glslang.vcxproj">
       <Project>{ef6834a9-11f3-4331-bc34-21b325abb180}</Project>
     </ProjectReference>
-    <ProjectReference Include="..\3rdparty\pthreads4w\build\pthreads4w.vcxproj">
-      <Project>{0fae817d-9a32-4830-857e-81da57246e16}</Project>
-    </ProjectReference>
     <ProjectReference Include="..\3rdparty\wxwidgets3.0\build\msw\wx30_base.vcxproj">
       <Project>{3fcc50c2-81e9-5db2-b8d8-2129427568b1}</Project>
     </ProjectReference>
diff --git a/pcsx2-qt/pcsx2-qt.vcxproj b/pcsx2-qt/pcsx2-qt.vcxproj
index b8366e2815..db6a476990 100644
--- a/pcsx2-qt/pcsx2-qt.vcxproj
+++ b/pcsx2-qt/pcsx2-qt.vcxproj
@@ -21,7 +21,6 @@
     <Import Project="$(SolutionDir)common\vsprops\common.props" />
     <Import Project="$(SolutionDir)common\vsprops\BaseProperties.props" />
     <Import Project="$(SolutionDir)common\vsprops\3rdpartyDeps.props" />
-    <Import Project="$(SolutionDir)common\vsprops\pthreads.props" />
     <Import Project="$(SolutionDir)common\vsprops\QtCompile.props" />
     <Import Condition="$(Configuration.Contains(Debug))" Project="$(SolutionDir)common\vsprops\CodeGen_Debug.props" />
     <Import Condition="$(Configuration.Contains(Devel))" Project="$(SolutionDir)common\vsprops\CodeGen_Devel.props" />
@@ -107,10 +106,6 @@
     <ProjectReference Include="$(SolutionDir)3rdparty\libsamplerate\libsamplerate.vcxproj">
       <Project>{47afdbef-f15f-4bc0-b436-5be443c3f80f}</Project>
     </ProjectReference>
-    <ProjectReference Include="$(SolutionDir)3rdparty\pthreads4w\build\pthreads4w.vcxproj">
-      <Project>{0fae817d-9a32-4830-857e-81da57246e16}</Project>
-      <ReferenceOutputAssembly>false</ReferenceOutputAssembly>
-    </ProjectReference>
     <ProjectReference Include="$(SolutionDir)3rdparty\soundtouch\SoundTouch.vcxproj">
       <Project>{e9b51944-7e6d-4bcd-83f2-7bbd5a46182d}</Project>
     </ProjectReference>
diff --git a/pcsx2/CMakeLists.txt b/pcsx2/CMakeLists.txt
index 89f5c5d02f..9dc3d3f829 100644
--- a/pcsx2/CMakeLists.txt
+++ b/pcsx2/CMakeLists.txt
@@ -1616,7 +1616,6 @@ endif()
 if(WIN32)
 	target_link_libraries(PCSX2_FLAGS INTERFACE
 		baseclasses
-		pthreads4w
 		WIL::WIL
 		D3D12MemAlloc
 		setupapi.lib
@@ -1635,6 +1634,11 @@ if(WIN32)
 		opengl32.lib
 		comsuppw.lib
 	)
+	if(NOT PCSX2_CORE)
+		target_link_libraries(PCSX2_FLAGS INTERFACE
+			pthreads4w
+		)
+	endif()
 elseif(APPLE)
 	target_link_libraries(PCSX2_FLAGS INTERFACE
 		PCAP::PCAP
diff --git a/pcsx2/PrecompiledHeader.h b/pcsx2/PrecompiledHeader.h
index 095164f879..152fd8d7df 100644
--- a/pcsx2/PrecompiledHeader.h
+++ b/pcsx2/PrecompiledHeader.h
@@ -53,7 +53,11 @@
 
 #include <stddef.h>
 #include <sys/stat.h>
+
+#ifndef PCSX2_CORE
+// pthreadsw32 is not needed when compiling PCSX2-Qt.
 #include <pthread.h>
+#endif
 
 
 #undef  TRUE
diff --git a/pcsx2/pcsx2core.vcxproj b/pcsx2/pcsx2core.vcxproj
index 35658da716..57a1f3b0c1 100644
--- a/pcsx2/pcsx2core.vcxproj
+++ b/pcsx2/pcsx2core.vcxproj
@@ -21,7 +21,6 @@
     <Import Project="$(SolutionDir)common\vsprops\common.props" />
     <Import Project="$(SolutionDir)common\vsprops\BaseProperties.props" />
     <Import Project="$(SolutionDir)common\vsprops\3rdpartyDeps.props" />
-    <Import Project="$(SolutionDir)common\vsprops\pthreads.props" />
     <Import Condition="$(Configuration.Contains(Debug))" Project="$(SolutionDir)common\vsprops\CodeGen_Debug.props" />
     <Import Condition="$(Configuration.Contains(Devel))" Project="$(SolutionDir)common\vsprops\CodeGen_Devel.props" />
     <Import Condition="$(Configuration.Contains(Release))" Project="$(SolutionDir)common\vsprops\CodeGen_Release.props" />
@@ -756,10 +755,6 @@
     <ProjectReference Include="$(SolutionDir)3rdparty\libsamplerate\libsamplerate.vcxproj">
       <Project>{47afdbef-f15f-4bc0-b436-5be443c3f80f}</Project>
     </ProjectReference>
-    <ProjectReference Include="$(SolutionDir)3rdparty\pthreads4w\build\pthreads4w.vcxproj">
-      <Project>{0fae817d-9a32-4830-857e-81da57246e16}</Project>
-      <ReferenceOutputAssembly>false</ReferenceOutputAssembly>
-    </ProjectReference>
     <ProjectReference Include="$(SolutionDir)3rdparty\soundtouch\SoundTouch.vcxproj">
       <Project>{e9b51944-7e6d-4bcd-83f2-7bbd5a46182d}</Project>
     </ProjectReference>
diff --git a/pcsx2/x86/ix86-32/iR5900-32.cpp b/pcsx2/x86/ix86-32/iR5900-32.cpp
index 9390d3ae9b..bedc310add 100644
--- a/pcsx2/x86/ix86-32/iR5900-32.cpp
+++ b/pcsx2/x86/ix86-32/iR5900-32.cpp
@@ -31,6 +31,7 @@
 
 #ifndef PCSX2_CORE
 #include "gui/SysThreads.h"
+#include <pthread.h>
 #else
 #include "VMManager.h"
 #endif
@@ -733,13 +734,15 @@ static void recExecute()
 	if (eeRecNeedsReset.load())
 		recResetRaw();
 
-	int oldstate;
 	m_cpuException = nullptr;
 	m_Exception    = nullptr;
 
 	// setjmp will save the register context and will return 0
 	// A call to longjmp will restore the context (included the eip/rip)
 	// but will return the longjmp 2nd parameter (here 1)
+#ifndef PCSX2_CORE
+	int oldstate;
+#endif
 	if (!fastjmp_set(&m_SetJmp_StateCheck))
 	{
 		eeCpuExecuting = true;
@@ -749,14 +752,18 @@ static void recExecute()
 		// in Linux, which cannot have a C++ exception cross the recompiler.  Hence the changing
 		// of the cancelstate here!
 
+#ifndef PCSX2_CORE
 		pthread_setcancelstate(PTHREAD_CANCEL_DISABLE, &oldstate);
+#endif
 		EnterRecompiledCode();
 
 		// Generally unreachable code here ...
 	}
 	else
 	{
+#ifndef PCSX2_CORE
 		pthread_setcancelstate(PTHREAD_CANCEL_ENABLE, &oldstate);
+#endif
 	}
 
 	eeCpuExecuting = false;