diff --git a/pcsx2/Frontend/OpenGLHostDisplay.cpp b/pcsx2/Frontend/OpenGLHostDisplay.cpp
index 31884ec531..8901685ff0 100644
--- a/pcsx2/Frontend/OpenGLHostDisplay.cpp
+++ b/pcsx2/Frontend/OpenGLHostDisplay.cpp
@@ -85,6 +85,9 @@ std::unique_ptr<HostDisplayTexture> OpenGLHostDisplay::CreateTexture(u32 width,
 	// clear error
 	glGetError();
 
+	// don't worry, I'm planning on removing this eventually - we'll use GSTexture instead.
+	glActiveTexture(GL_TEXTURE7);
+
 	GLuint id;
 	glGenTextures(1, &id);
 	glBindTexture(GL_TEXTURE_2D, id);
@@ -100,6 +103,8 @@ std::unique_ptr<HostDisplayTexture> OpenGLHostDisplay::CreateTexture(u32 width,
 		glTexImage2D(GL_TEXTURE_2D, 0, GL_RGBA8, width, height, 0, GL_RGBA, GL_UNSIGNED_BYTE, data);
 	}
 
+	glActiveTexture(GL_TEXTURE0);
+
 	GLenum error = glGetError();
 	if (error != GL_NO_ERROR)
 	{
@@ -115,30 +120,15 @@ void OpenGLHostDisplay::UpdateTexture(HostDisplayTexture* texture, u32 x, u32 y,
 {
 	OpenGLHostDisplayTexture* tex = static_cast<OpenGLHostDisplayTexture*>(texture);
 
-	GLint alignment;
-	if (texture_data_stride & 1)
-		alignment = 1;
-	else if (texture_data_stride & 2)
-		alignment = 2;
-	else
-		alignment = 4;
+	glActiveTexture(GL_TEXTURE7);
 
-	GLint old_texture_binding = 0, old_alignment = 0, old_row_length = 0;
-	glGetIntegerv(GL_TEXTURE_BINDING_2D, &old_texture_binding);
-	glBindTexture(GL_TEXTURE_2D, tex->GetGLID());
-
-	glGetIntegerv(GL_UNPACK_ALIGNMENT, &old_alignment);
-	glPixelStorei(GL_UNPACK_ALIGNMENT, alignment);
-
-	glGetIntegerv(GL_UNPACK_ROW_LENGTH, &old_row_length);
 	glPixelStorei(GL_UNPACK_ROW_LENGTH, texture_data_stride / sizeof(u32));
 
 	glTexSubImage2D(GL_TEXTURE_2D, 0, x, y, width, height, GL_RGBA8, GL_UNSIGNED_BYTE, texture_data);
 
-	glPixelStorei(GL_UNPACK_ROW_LENGTH, old_row_length);
+	glPixelStorei(GL_UNPACK_ROW_LENGTH, 0);
 
-	glPixelStorei(GL_UNPACK_ALIGNMENT, old_alignment);
-	glBindTexture(GL_TEXTURE_2D, old_texture_binding);
+	glActiveTexture(GL_TEXTURE0);
 }
 
 void OpenGLHostDisplay::SetVSync(VsyncMode mode)
@@ -216,6 +206,9 @@ bool OpenGLHostDisplay::CreateDevice(const WindowInfo& wi, VsyncMode vsync)
 
 bool OpenGLHostDisplay::SetupDevice()
 {
+	// We do use 8-bit formats, and higher alignment for 32-bit formats won't hurt anything.
+	glPixelStorei(GL_UNPACK_ALIGNMENT, 1);
+
 	SetSwapInterval();
 	GL::Program::ResetLastProgram();
 	return true;
@@ -363,11 +356,8 @@ bool OpenGLHostDisplay::BeginPresent(bool frame_skip)
 
 void OpenGLHostDisplay::EndPresent()
 {
-	// clear out pipeline bindings, since imgui doesn't use them
-	glBindProgramPipeline(0);
 	glDisable(GL_SCISSOR_TEST);
 	glDisable(GL_STENCIL_TEST);
-	glActiveTexture(GL_TEXTURE0);
 
 	ImGui::Render();
 	ImGui_ImplOpenGL3_RenderDrawData(ImGui::GetDrawData());
diff --git a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
index 11d069acdd..47a5cc0c42 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
+++ b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
@@ -477,13 +477,14 @@ bool GSDeviceOGL::Create()
 	// ****************************************************************
 	if (!GLLoader::buggy_pbo)
 	{
-		// Mesa seems to use it to compute the row length. In our case, we are
-		// tightly packed so don't bother with this parameter and set it to the
-		// minimum alignment (1 byte)
-		glPixelStorei(GL_UNPACK_ALIGNMENT, 1);
-
 		s_texture_upload_buffer = GL::StreamBuffer::Create(GL_PIXEL_UNPACK_BUFFER, TEXTURE_UPLOAD_BUFFER_SIZE);
-		if (!s_texture_upload_buffer)
+		if (s_texture_upload_buffer)
+		{
+			// Don't keep it bound, we'll re-bind when we need it.
+			// Otherwise non-PBO texture uploads break. Yay for global state.
+			s_texture_upload_buffer->Unbind();
+		}
+		else
 		{
 			Console.Error("Failed to create texture upload buffer. Using slow path.");
 			GLLoader::buggy_pbo = true;
@@ -569,6 +570,7 @@ void GSDeviceOGL::ResetAPIState()
 	// clear out DSB
 	glBlendFuncSeparate(GL_ONE, GL_ZERO, GL_ONE, GL_ZERO);
 	glDisable(GL_BLEND);
+	glActiveTexture(GL_TEXTURE0);
 }
 
 void GSDeviceOGL::RestoreAPIState()
diff --git a/pcsx2/GS/Renderers/OpenGL/GSTextureOGL.cpp b/pcsx2/GS/Renderers/OpenGL/GSTextureOGL.cpp
index 7a124ef2ee..5235335682 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSTextureOGL.cpp
+++ b/pcsx2/GS/Renderers/OpenGL/GSTextureOGL.cpp
@@ -256,6 +256,8 @@ bool GSTextureOGL::Update(const GSVector4i& r, const void* data, int pitch, int
 
 		glTextureSubImage2D(m_texture_id, layer, r.x, r.y, r.width(), r.height(), m_int_format, m_int_type,
 			reinterpret_cast<void*>(static_cast<uintptr_t>(map.buffer_offset)));
+
+		sb->Unbind();
 	}
 
 	m_needs_mipmaps_generated = true;
@@ -316,6 +318,8 @@ void GSTextureOGL::Unmap()
 		glTextureSubImage2D(m_texture_id, m_layer, m_r_x, m_r_y, m_r_w, m_r_h, m_int_format, m_int_type,
 			reinterpret_cast<void*>(static_cast<uintptr_t>(m_map_offset)));
 
+		sb->Unbind();
+
 		m_needs_mipmaps_generated = true;
 
 		GL_POP(); // PUSH is in Map