diff --git a/pcsx2/x86/microVU_Compile.inl b/pcsx2/x86/microVU_Compile.inl
index 62c07eadcc..8bff1faa17 100644
--- a/pcsx2/x86/microVU_Compile.inl
+++ b/pcsx2/x86/microVU_Compile.inl
@@ -561,6 +561,9 @@ void* mVUcompile(microVU& mVU, u32 startPC, uptr pState)
 		mVUcheckBadOp(mVU);
 		if (curI & _Ebit_) {
 			eBitPass1(mVU, branch);
+			// VU0 end of program MAC results can be read by COP2, so best to make sure the last instance is valid
+			// Needed for State of Emergency 2 and Driving Emotion Type-S
+			if(isVU0) mVUregs.needExactMatch |= 7;
 		}
 
 		if ((curI & _Mbit_) && isVU0) {