diff --git a/pcsx2/gui/AppConfig.cpp b/pcsx2/gui/AppConfig.cpp
index 6a50e91ee1..7e75d2e9a4 100644
--- a/pcsx2/gui/AppConfig.cpp
+++ b/pcsx2/gui/AppConfig.cpp
@@ -1047,7 +1047,7 @@ bool AppConfig::IsOkApplyPreset(int n)
 	EmuOptions.Gamefixes			= default_Pcsx2Config.Gamefixes;
 	EmuOptions.Speedhacks			= default_Pcsx2Config.Speedhacks;
 	EmuOptions.Speedhacks.bitset	= 0; //Turn off individual hacks to make it visually clear they're not used.
-	EmuOptions.Speedhacks.vuThread	= original_SpeedHacks.vuThread; // MTVU is not modified by presets
+	EmuOptions.Speedhacks.vuThread	= original_SpeedHacks.vuThread;
 	EnableSpeedHacks = true;
 
 	//Actual application of current preset over the base settings which all presets use (mostly pcsx2's default values).
@@ -1079,11 +1079,13 @@ bool AppConfig::IsOkApplyPreset(int n)
 					EmuOptions.Speedhacks.IntcStat = true;
 					EmuOptions.Speedhacks.WaitLoop = true;
 					EmuOptions.Speedhacks.vuFlagHack = true;
+					break;
 
 		case 0 :	//Base preset: Mostly pcsx2's defaults.
-					
-		
+					//Force disable MTVU hack on safest preset as it has lots of issues (Crashes/Slow downs) on various games.
+					EmuOptions.Speedhacks.vuThread = false;
 					break;
+
 		default:	Console.WriteLn("Developer Warning: Preset #%d is not implemented. (--> Using application default).", n);
 	}
 
diff --git a/pcsx2/gui/Panels/SpeedhacksPanel.cpp b/pcsx2/gui/Panels/SpeedhacksPanel.cpp
index a5c664726e..d3b7f5839f 100644
--- a/pcsx2/gui/Panels/SpeedhacksPanel.cpp
+++ b/pcsx2/gui/Panels/SpeedhacksPanel.cpp
@@ -281,7 +281,8 @@ void Panels::SpeedHacksPanel::EnableStuff( AppConfig* configToUse )
 	m_check_waitloop->Enable(HacksEnabledAndNoPreset);
 	m_check_fastCDVD->Enable(HacksEnabledAndNoPreset);
 
-	m_check_vuThread->Enable(hacksEnabled); // MTVU is unaffected by presets
+	// Grayout MTVU on safest preset
+	m_check_vuThread->Enable(hacksEnabled && (!hasPreset || configToUse->PresetIndex != 0));
 
 	// Layout necessary to ensure changed slider text gets re-aligned properly
 	// and to properly gray/ungray pxStaticText stuff (I suspect it causes a
@@ -309,12 +310,14 @@ void Panels::SpeedHacksPanel::ApplyConfigToGui( AppConfig& configToApply, int fl
 	SetVUcycleSliderMsg();
 
 	m_check_vuFlagHack->SetValue(opts.vuFlagHack);
-	if( !(flags & AppConfig::APPLY_FLAG_FROM_PRESET) )
-		m_check_vuThread	->SetValue(opts.vuThread);
 	m_check_intc->SetValue(opts.IntcStat);
 	m_check_waitloop->SetValue(opts.WaitLoop);
 	m_check_fastCDVD->SetValue(opts.fastCDVD);
 
+	const bool preset_request = flags & AppConfig::APPLY_FLAG_FROM_PRESET;
+	if (!preset_request || configToApply.PresetIndex == 0)
+		m_check_vuThread->SetValue(opts.vuThread);
+
 	// Then, lock(gray out)/unlock the widgets as necessary.
 	EnableStuff( &configToApply );