diff --git a/common/SettingsInterface.h b/common/SettingsInterface.h
index 8ac443bc17..79747b2a52 100644
--- a/common/SettingsInterface.h
+++ b/common/SettingsInterface.h
@@ -42,11 +42,12 @@ public:
 	virtual void SetBoolValue(const char* section, const char* key, bool value) = 0;
 	virtual void SetStringValue(const char* section, const char* key, const char* value) = 0;
 
-	virtual std::vector<std::string> GetStringList(const char* section, const char* key) = 0;
+	virtual std::vector<std::string> GetStringList(const char* section, const char* key) const = 0;
 	virtual void SetStringList(const char* section, const char* key, const std::vector<std::string>& items) = 0;
 	virtual bool RemoveFromStringList(const char* section, const char* key, const char* item) = 0;
 	virtual bool AddToStringList(const char* section, const char* key, const char* item) = 0;
 
+	virtual bool ContainsValue(const char* section, const char* key) const = 0;
 	virtual void DeleteValue(const char* section, const char* key) = 0;
 	virtual void ClearSection(const char* section) = 0;
 
@@ -153,4 +154,67 @@ public:
 	{
 		value.has_value() ? SetStringValue(section, key, value.value()) : DeleteValue(section, key);
 	}
+
+	__fi void CopyBoolValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		bool value;
+		if (si.GetBoolValue(section, key, &value))
+			SetBoolValue(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyIntValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		int value;
+		if (si.GetIntValue(section, key, &value))
+			SetIntValue(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyUIntValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		uint value;
+		if (si.GetUIntValue(section, key, &value))
+			SetUIntValue(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyFloatValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		float value;
+		if (si.GetFloatValue(section, key, &value))
+			SetFloatValue(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyDoubleValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		double value;
+		if (si.GetDoubleValue(section, key, &value))
+			SetDoubleValue(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyStringValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		std::string value;
+		if (si.GetStringValue(section, key, &value))
+			SetStringValue(section, key, value.c_str());
+		else
+			DeleteValue(section, key);
+	}
+
+	__fi void CopyStringListValue(const SettingsInterface& si, const char* section, const char* key)
+	{
+		std::vector<std::string> value(si.GetStringList(section, key));
+		if (!value.empty())
+			SetStringList(section, key, value);
+		else
+			DeleteValue(section, key);
+	}
 };
diff --git a/pcsx2/Frontend/INISettingsInterface.cpp b/pcsx2/Frontend/INISettingsInterface.cpp
index 048807f65c..7a23c817ad 100644
--- a/pcsx2/Frontend/INISettingsInterface.cpp
+++ b/pcsx2/Frontend/INISettingsInterface.cpp
@@ -185,6 +185,11 @@ void INISettingsInterface::SetStringValue(const char* section, const char* key,
 	m_ini.SetValue(section, key, value, nullptr, true);
 }
 
+bool INISettingsInterface::ContainsValue(const char* section, const char* key) const
+{
+	return (m_ini.GetValue(section, key, nullptr) != nullptr);
+}
+
 void INISettingsInterface::DeleteValue(const char* section, const char* key)
 {
 	m_dirty = true;
diff --git a/pcsx2/Frontend/INISettingsInterface.h b/pcsx2/Frontend/INISettingsInterface.h
index 5c6dd4e710..e258ed23e8 100644
--- a/pcsx2/Frontend/INISettingsInterface.h
+++ b/pcsx2/Frontend/INISettingsInterface.h
@@ -48,6 +48,7 @@ public:
 	void SetDoubleValue(const char* section, const char* key, double value) override;
 	void SetBoolValue(const char* section, const char* key, bool value) override;
 	void SetStringValue(const char* section, const char* key, const char* value) override;
+	bool ContainsValue(const char* section, const char* key) const override;
 	void DeleteValue(const char* section, const char* key) override;
 	void ClearSection(const char* section) override;
 
diff --git a/pcsx2/Frontend/LayeredSettingsInterface.cpp b/pcsx2/Frontend/LayeredSettingsInterface.cpp
index d1e9ad9ae8..453e76c546 100644
--- a/pcsx2/Frontend/LayeredSettingsInterface.cpp
+++ b/pcsx2/Frontend/LayeredSettingsInterface.cpp
@@ -147,6 +147,19 @@ void LayeredSettingsInterface::SetStringValue(const char* section, const char* k
 	pxFailRel("Attempt to call SetStringValue() on layered settings interface");
 }
 
+bool LayeredSettingsInterface::ContainsValue(const char* section, const char* key) const
+{
+	for (u32 layer = FIRST_LAYER; layer <= LAST_LAYER; layer++)
+	{
+		if (SettingsInterface* sif = m_layers[layer]; sif != nullptr)
+		{
+			if (sif->ContainsValue(key, section))
+				return true;
+		}
+	}
+	return false;
+}
+
 void LayeredSettingsInterface::DeleteValue(const char* section, const char* key)
 {
 	pxFailRel("Attempt to call DeleteValue() on layered settings interface");
@@ -157,7 +170,7 @@ void LayeredSettingsInterface::ClearSection(const char* section)
 	pxFailRel("Attempt to call ClearSection() on layered settings interface");
 }
 
-std::vector<std::string> LayeredSettingsInterface::GetStringList(const char* section, const char* key)
+std::vector<std::string> LayeredSettingsInterface::GetStringList(const char* section, const char* key) const
 {
 	std::vector<std::string> ret;
 
diff --git a/pcsx2/Frontend/LayeredSettingsInterface.h b/pcsx2/Frontend/LayeredSettingsInterface.h
index f23ebc59d3..a18aab455d 100644
--- a/pcsx2/Frontend/LayeredSettingsInterface.h
+++ b/pcsx2/Frontend/LayeredSettingsInterface.h
@@ -52,10 +52,11 @@ public:
 	void SetDoubleValue(const char* section, const char* key, double value) override;
 	void SetBoolValue(const char* section, const char* key, bool value) override;
 	void SetStringValue(const char* section, const char* key, const char* value) override;
+	bool ContainsValue(const char* section, const char* key) const override;
 	void DeleteValue(const char* section, const char* key) override;
 	void ClearSection(const char* section) override;
 
-	std::vector<std::string> GetStringList(const char* section, const char* key) override;
+	std::vector<std::string> GetStringList(const char* section, const char* key) const override;
 	void SetStringList(const char* section, const char* key, const std::vector<std::string>& items) override;
 	bool RemoveFromStringList(const char* section, const char* key, const char* item) override;
 	bool AddToStringList(const char* section, const char* key, const char* item) override;
diff --git a/pcsx2/HostSettings.cpp b/pcsx2/HostSettings.cpp
index 77ec09ecf0..2e0273775e 100644
--- a/pcsx2/HostSettings.cpp
+++ b/pcsx2/HostSettings.cpp
@@ -32,6 +32,12 @@ SettingsInterface* Host::GetSettingsInterface()
 	return &s_layered_settings_interface;
 }
 
+SettingsInterface* Host::GetSettingsInterfaceForBindings()
+{
+	SettingsInterface* input_layer = s_layered_settings_interface.GetLayer(LayeredSettingsInterface::LAYER_INPUT);
+	return input_layer ? input_layer : &s_layered_settings_interface;
+}
+
 std::string Host::GetBaseStringSettingValue(const char* section, const char* key, const char* default_value /*= ""*/)
 {
 	std::unique_lock lock(s_settings_mutex);
@@ -169,6 +175,16 @@ SettingsInterface* Host::Internal::GetBaseSettingsLayer()
 	return s_layered_settings_interface.GetLayer(LayeredSettingsInterface::LAYER_BASE);
 }
 
+SettingsInterface* Host::Internal::GetGameSettingsLayer()
+{
+	return s_layered_settings_interface.GetLayer(LayeredSettingsInterface::LAYER_GAME);
+}
+
+SettingsInterface* Host::Internal::GetInputSettingsLayer()
+{
+	return s_layered_settings_interface.GetLayer(LayeredSettingsInterface::LAYER_INPUT);
+}
+
 void Host::Internal::SetBaseSettingsLayer(SettingsInterface* sif)
 {
 	pxAssertRel(s_layered_settings_interface.GetLayer(LayeredSettingsInterface::LAYER_BASE) == nullptr, "Base layer has not been set");
diff --git a/pcsx2/HostSettings.h b/pcsx2/HostSettings.h
index 26967a2e65..e99c0c0bd5 100644
--- a/pcsx2/HostSettings.h
+++ b/pcsx2/HostSettings.h
@@ -56,11 +56,21 @@ namespace Host
 	std::unique_lock<std::mutex> GetSettingsLock();
 	SettingsInterface* GetSettingsInterface();
 
+	/// Returns the settings interface that controller bindings should be loaded from.
+	/// If an input profile is being used, this will be the input layer, otherwise the layered interface.
+	SettingsInterface* GetSettingsInterfaceForBindings();
+
 	namespace Internal
 	{
 		/// Retrieves the base settings layer. Must call with lock held.
 		SettingsInterface* GetBaseSettingsLayer();
 
+		/// Retrieves the game settings layer, if present. Must call with lock held.
+		SettingsInterface* GetGameSettingsLayer();
+
+		/// Retrieves the input settings layer, if present. Must call with lock held.
+		SettingsInterface* GetInputSettingsLayer();
+
 		/// Sets the base settings layer. Should be called by the host at initialization time.
 		void SetBaseSettingsLayer(SettingsInterface* sif);
 
diff --git a/pcsx2/gui/wxSettingsInterface.cpp b/pcsx2/gui/wxSettingsInterface.cpp
index ac74a2278a..c2c238e164 100644
--- a/pcsx2/gui/wxSettingsInterface.cpp
+++ b/pcsx2/gui/wxSettingsInterface.cpp
@@ -141,7 +141,7 @@ void wxSettingsInterface::SetStringValue(const char* section, const char* key, c
 	m_config->Write(key, wxString::FromUTF8(value));
 }
 
-std::vector<std::string> wxSettingsInterface::GetStringList(const char* section, const char* key)
+std::vector<std::string> wxSettingsInterface::GetStringList(const char* section, const char* key) const
 {
 	pxFailRel("Not implemented");
 	return {};
@@ -163,6 +163,12 @@ bool wxSettingsInterface::AddToStringList(const char* section, const char* key,
 	return false;
 }
 
+bool wxSettingsInterface::ContainsValue(const char* section, const char* key) const
+{
+	CheckPath(section);
+	return m_config->Exists(key);
+}
+
 void wxSettingsInterface::DeleteValue(const char* section, const char* key)
 {
 	CheckPath(section);
diff --git a/pcsx2/gui/wxSettingsInterface.h b/pcsx2/gui/wxSettingsInterface.h
index 416501eec1..258dcc45d0 100644
--- a/pcsx2/gui/wxSettingsInterface.h
+++ b/pcsx2/gui/wxSettingsInterface.h
@@ -44,11 +44,12 @@ public:
 
   void SetStringValue(const char* section, const char* key, const char* value) override;
 
-  std::vector<std::string> GetStringList(const char* section, const char* key) override;
+  std::vector<std::string> GetStringList(const char* section, const char* key) const override;
   void SetStringList(const char* section, const char* key, const std::vector<std::string>& items) override;
   bool RemoveFromStringList(const char* section, const char* key, const char* item) override;
   bool AddToStringList(const char* section, const char* key, const char* item) override;
 
+  bool ContainsValue(const char* section, const char* key) const override;
   void DeleteValue(const char* section, const char* key) override;
   void ClearSection(const char* section) override;