diff --git a/pcsx2-qt/Settings/GraphicsSettingsWidget.cpp b/pcsx2-qt/Settings/GraphicsSettingsWidget.cpp
index 9e83a1b495..9609afaab0 100644
--- a/pcsx2-qt/Settings/GraphicsSettingsWidget.cpp
+++ b/pcsx2-qt/Settings/GraphicsSettingsWidget.cpp
@@ -198,18 +198,13 @@ GraphicsSettingsWidget::GraphicsSettingsWidget(SettingsDialog* dialog, QWidget*
 	SettingWidgetBinder::BindWidgetToIntSetting(
 		sif, m_ui.textureInsideRt, "EmuCore/GS", "UserHacks_TextureInsideRt", static_cast<int>(GSTextureInRtMode::Disabled));
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.readTCOnClose, "EmuCore/GS", "UserHacks_ReadTCOnClose", false);
-	SettingWidgetBinder::BindWidgetToBoolSetting(
-		sif, m_ui.targetPartialInvalidation, "EmuCore/GS", "UserHacks_TargetPartialInvalidation", false);
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.estimateTextureRegion, "EmuCore/GS", "UserHacks_EstimateTextureRegion", false);
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.gpuPaletteConversion, "EmuCore/GS", "paltex", false);
 	connect(m_ui.cpuSpriteRenderBW, QOverload<int>::of(&QComboBox::currentIndexChanged), this,
 		&GraphicsSettingsWidget::onCPUSpriteRenderBWChanged);
-	connect(
-		m_ui.textureInsideRt, QOverload<int>::of(&QComboBox::currentIndexChanged), this, &GraphicsSettingsWidget::onTextureInsideRtChanged);
 	connect(m_ui.gpuPaletteConversion, QOverload<int>::of(&QCheckBox::stateChanged), this,
 		&GraphicsSettingsWidget::onGpuPaletteConversionChanged);
 	onCPUSpriteRenderBWChanged();
-	onTextureInsideRtChanged();
 	onGpuPaletteConversionChanged(m_ui.gpuPaletteConversion->checkState());
 
 	//////////////////////////////////////////////////////////////////////////
@@ -559,10 +554,6 @@ GraphicsSettingsWidget::GraphicsSettingsWidget(SettingsDialog* dialog, QWidget*
 			tr("Flushes all targets in the texture cache back to local memory when shutting down. Can prevent lost visuals when saving "
 			   "state or switching renderers, but can also cause graphical corruption."));
 
-		dialog->registerWidgetHelp(m_ui.targetPartialInvalidation, tr("Target Partial Invalidation"), tr("Unchecked"),
-			tr("Allows partial invalidation of render targets, which can fix graphical errors in some games. Texture Inside Render Target "
-			   "automatically enables this option."));
-
 		dialog->registerWidgetHelp(m_ui.estimateTextureRegion, tr("Estimate Texture Region"), tr("Unchecked"),
 			tr("Attempts to reduce the texture size when games do not set it themselves (e.g. Snowblind games)."));
 	}
@@ -889,13 +880,6 @@ void GraphicsSettingsWidget::onCPUSpriteRenderBWChanged()
 	m_ui.cpuSpriteRenderLevel->setEnabled(value != 0);
 }
 
-void GraphicsSettingsWidget::onTextureInsideRtChanged()
-{
-	const bool disabled = static_cast<GSTextureInRtMode>(m_ui.textureInsideRt->currentIndex()) >= GSTextureInRtMode::InsideTargets;
-
-	m_ui.targetPartialInvalidation->setDisabled(disabled);
-}
-
 GSRendererType GraphicsSettingsWidget::getEffectiveRenderer() const
 {
 	const GSRendererType type =
@@ -1060,7 +1044,6 @@ void GraphicsSettingsWidget::resetManualHardwareFixes()
 		check_bool("EmuCore/GS", "UserHacks_DisablePartialInvalidation", false);
 		check_int("EmuCore/GS", "UserHacks_TextureInsideRt", static_cast<int>(GSTextureInRtMode::Disabled));
 		check_bool("EmuCore/GS", "UserHacks_ReadTCOnClose", false);
-		check_bool("EmuCore/GS", "UserHacks_TargetPartialInvalidation", false);
 		check_bool("EmuCore/GS", "UserHacks_EstimateTextureRegion", false);
 		check_bool("EmuCore/GS", "paltex", false);
 		check_int("EmuCore/GS", "UserHacks_HalfPixelOffset", 0);
diff --git a/pcsx2-qt/Settings/GraphicsSettingsWidget.h b/pcsx2-qt/Settings/GraphicsSettingsWidget.h
index 592827289c..248aa8d277 100644
--- a/pcsx2-qt/Settings/GraphicsSettingsWidget.h
+++ b/pcsx2-qt/Settings/GraphicsSettingsWidget.h
@@ -42,7 +42,6 @@ private Q_SLOTS:
 	void onTrilinearFilteringChanged();
 	void onGpuPaletteConversionChanged(int state);
 	void onCPUSpriteRenderBWChanged();
-	void onTextureInsideRtChanged();
 	void onFullscreenModeChanged(int index);
 	void onShadeBoostChanged();
 	void onCaptureContainerChanged();
diff --git a/pcsx2-qt/Settings/GraphicsSettingsWidget.ui b/pcsx2-qt/Settings/GraphicsSettingsWidget.ui
index 21103d6841..ae561dfa65 100644
--- a/pcsx2-qt/Settings/GraphicsSettingsWidget.ui
+++ b/pcsx2-qt/Settings/GraphicsSettingsWidget.ui
@@ -1027,13 +1027,6 @@
            </property>
           </widget>
          </item>
-         <item row="4" column="1">
-          <widget class="QCheckBox" name="targetPartialInvalidation">
-           <property name="text">
-            <string>Target Partial Invalidation</string>
-           </property>
-          </widget>
-         </item>
          <item row="3" column="1">
           <widget class="QCheckBox" name="readTCOnClose">
            <property name="text">