diff --git a/pcsx2/GS/Renderers/OpenGL/GSRendererOGL.cpp b/pcsx2/GS/Renderers/OpenGL/GSRendererOGL.cpp
index a289682571..90f1fee9de 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSRendererOGL.cpp
+++ b/pcsx2/GS/Renderers/OpenGL/GSRendererOGL.cpp
@@ -492,7 +492,7 @@ void GSRendererOGL::EmulateBlending(bool& DATE_GL42, bool& DATE_GL45)
 	const bool blend_mix1 = !!(blend_flag & BLEND_MIX1);
 	const bool blend_mix2 = !!(blend_flag & BLEND_MIX2);
 	const bool blend_mix3 = !!(blend_flag & BLEND_MIX3);
-	bool blend_mix  = (blend_mix1 || blend_mix2 || blend_mix3)
+	bool blend_mix = (blend_mix1 || blend_mix2 || blend_mix3)
 		// Do not enable if As > 128 or F > 128, hw blend clamps to 1
 		&& !((ALPHA.C == 0 && m_vt.m_alpha.max > 128) || (ALPHA.C == 2 && ALPHA.FIX > 128u));
 
@@ -500,7 +500,6 @@ void GSRendererOGL::EmulateBlending(bool& DATE_GL42, bool& DATE_GL45)
 	const bool impossible_or_free_blend = (blend_flag & BLEND_A_MAX) // Impossible blending
 		|| blend_non_recursive                 // Free sw blending, doesn't require barriers or reading fb
 		|| accumulation_blend                  // Mix of hw/sw blending
-		|| blend_mix                           // Mix of hw/sw blending
 		|| (m_prim_overlap == PRIM_OVERLAP_NO) // Blend can be done in a single draw
 		|| (m_require_full_barrier);           // Another effect (for example fbmask) already requires a full barrier
 
@@ -531,6 +530,13 @@ void GSRendererOGL::EmulateBlending(bool& DATE_GL42, bool& DATE_GL45)
 			/*sw_blending |= accumulation_blend*/;
 	}
 
+	// Do not run BLEND MIX if sw blending is already present, it's less accurate
+	if (m_sw_blending)
+	{
+		blend_mix &= !sw_blending;
+		sw_blending |= blend_mix;
+	}
+
 	// Color clip
 	if (m_env.COLCLAMP.CLAMP == 0)
 	{