diff --git a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
index 56cd130bae..9a3a3ba429 100644
--- a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
+++ b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
@@ -5233,7 +5233,8 @@ __ri void GSRendererHW::DrawPrims(GSTextureCache::Target* rt, GSTextureCache::Ta
 
 	m_prim_overlap = PrimitiveOverlap();
 
-	EmulateTextureShuffleAndFbmask(rt, tex);
+	if (rt)
+		EmulateTextureShuffleAndFbmask(rt, tex);
 
 	const GSDevice::FeatureSupport features = g_gs_device->Features();