diff --git a/pcsx2/gui/Panels/GameFixesPanel.cpp b/pcsx2/gui/Panels/GameFixesPanel.cpp
index f1d0e87e9b..5c82b579cf 100644
--- a/pcsx2/gui/Panels/GameFixesPanel.cpp
+++ b/pcsx2/gui/Panels/GameFixesPanel.cpp
@@ -146,6 +146,8 @@ void Panels::GameFixesPanel::EnableStuff( AppConfig* configToUse )
 	if( !configToUse ) configToUse = g_Conf;
 	for (GamefixId i=GamefixId_FIRST; i < pxEnumEnd; ++i)
 		m_checkbox[i]->Enable(m_check_Enable->GetValue() && !configToUse->EnablePresets);
+
+	Layout();
 }
 
 void Panels::GameFixesPanel::OnEnable_Toggled( wxCommandEvent& evt )
diff --git a/pcsx2/gui/Panels/SpeedhacksPanel.cpp b/pcsx2/gui/Panels/SpeedhacksPanel.cpp
index 2975967b58..b4265eca46 100644
--- a/pcsx2/gui/Panels/SpeedhacksPanel.cpp
+++ b/pcsx2/gui/Panels/SpeedhacksPanel.cpp
@@ -265,6 +265,11 @@ void Panels::SpeedHacksPanel::EnableStuff( AppConfig* configToUse )
 	m_check_fastCDVD->Enable(HacksEnabledAndNoPreset);
 
 	m_check_vuThread->Enable(hacksEnabled); // MTVU is unaffected by presets
+
+	// Layout necessary to ensure changed slider text gets re-aligned properly
+	// and to properly gray/ungray pxStaticText stuff (I suspect it causes a
+	// paint event to be sent on Windows)
+	Layout();
 }
 
 void Panels::SpeedHacksPanel::AppStatusEvent_OnSettingsApplied()
@@ -296,9 +301,6 @@ void Panels::SpeedHacksPanel::ApplyConfigToGui( AppConfig& configToApply, int fl
 	// Then, lock(gray out)/unlock the widgets as necessary.
 	EnableStuff( &configToApply );
 
-	// Layout necessary to ensure changed slider text gets re-aligned properly
-	Layout();
-
 	//Console.WriteLn("SpeedHacksPanel::ApplyConfigToGui: EnabledPresets: %s", configToApply.EnablePresets?"true":"false");
 }
 
diff --git a/pcsx2/gui/Panels/VideoPanel.cpp b/pcsx2/gui/Panels/VideoPanel.cpp
index a6f6b55afd..0dc7b8545f 100644
--- a/pcsx2/gui/Panels/VideoPanel.cpp
+++ b/pcsx2/gui/Panels/VideoPanel.cpp
@@ -358,5 +358,7 @@ void Panels::VideoPanel::ApplyConfigToGui( AppConfig& configToApply, int flags )
 		m_span->ApplyConfigToGui( configToApply, true );
 		m_fpan->ApplyConfigToGui( configToApply, true );
 	}
+
+	Layout();
 }