diff --git a/pcsx2-gsrunner/Main.cpp b/pcsx2-gsrunner/Main.cpp
index 0430a5d770..7d5578f5b8 100644
--- a/pcsx2-gsrunner/Main.cpp
+++ b/pcsx2-gsrunner/Main.cpp
@@ -597,7 +597,7 @@ bool GSRunner::ParseCommandLineArgs(int argc, char* argv[], VMBootParameters& pa
 			else if (CHECK_ARG("-noshadercache"))
 			{
 				Console.WriteLn("Disabling shader cache");
-				s_settings_interface.SetBoolValue("EmuCore/GS", "disable_shader_cache", false);
+				s_settings_interface.SetBoolValue("EmuCore/GS", "disable_shader_cache", true);
 				continue;
 			}
 			else if (CHECK_ARG("-window"))
diff --git a/pcsx2/Frontend/VulkanHostDisplay.cpp b/pcsx2/Frontend/VulkanHostDisplay.cpp
index e34200e255..7499e27684 100644
--- a/pcsx2/Frontend/VulkanHostDisplay.cpp
+++ b/pcsx2/Frontend/VulkanHostDisplay.cpp
@@ -294,7 +294,8 @@ bool VulkanHostDisplay::CreateDevice(const WindowInfo& wi, VsyncMode vsync)
 
 bool VulkanHostDisplay::SetupDevice()
 {
-	Vulkan::ShaderCache::Create(EmuFolders::Cache, SHADER_CACHE_VERSION, EmuConfig.GS.UseDebugDevice);
+	Vulkan::ShaderCache::Create(EmuConfig.GS.DisableShaderCache ? std::string_view() : std::string_view(EmuFolders::Cache),
+		SHADER_CACHE_VERSION, EmuConfig.GS.UseDebugDevice);
 	return true;
 }