diff --git a/pcsx2-qt/Debugger/CpuWidget.cpp b/pcsx2-qt/Debugger/CpuWidget.cpp
index 9cee5effe3..0928ecf076 100644
--- a/pcsx2-qt/Debugger/CpuWidget.cpp
+++ b/pcsx2-qt/Debugger/CpuWidget.cpp
@@ -373,6 +373,9 @@ void CpuWidget::fixBPListColumnSize()
 
 void CpuWidget::onBPListContextMenu(QPoint pos)
 {
+	if (!m_cpu.isAlive())
+		return;
+
 	if (m_bplistContextMenu)
 		delete m_bplistContextMenu;
 
@@ -951,6 +954,9 @@ std::vector<u32> startWorker(DebugInterface* cpu, int type, u32 start, u32 end,
 
 void CpuWidget::onSearchButtonClicked()
 {
+	if (!m_cpu.isAlive())
+		return;
+
 	const int searchType = m_ui.cmbSearchType->currentIndex();
 	const bool searchHex = m_ui.chkSearchHex->isChecked();
 
diff --git a/pcsx2-qt/Debugger/DisassemblyWidget.cpp b/pcsx2-qt/Debugger/DisassemblyWidget.cpp
index 44365a95db..57afb9612e 100644
--- a/pcsx2-qt/Debugger/DisassemblyWidget.cpp
+++ b/pcsx2-qt/Debugger/DisassemblyWidget.cpp
@@ -151,6 +151,9 @@ void DisassemblyWidget::contextJumpToCursor()
 
 void DisassemblyWidget::contextToggleBreakpoint()
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	if (CBreakPoints::IsAddressBreakPoint(m_cpu->getCpuType(), m_selectedAddressStart))
 	{
 		Host::RunOnCPUThread([&] { CBreakPoints::RemoveBreakPoint(m_cpu->getCpuType(), m_selectedAddressStart); });
@@ -504,6 +507,9 @@ void DisassemblyWidget::mousePressEvent(QMouseEvent* event)
 
 void DisassemblyWidget::mouseDoubleClickEvent(QMouseEvent* event)
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	const u32 selectedAddress = (event->y() / m_rowHeight * 4) + m_visibleStart;
 	if (CBreakPoints::IsAddressBreakPoint(m_cpu->getCpuType(), selectedAddress))
 	{
@@ -597,6 +603,9 @@ void DisassemblyWidget::keyPressEvent(QKeyEvent* event)
 
 void DisassemblyWidget::customMenuRequested(QPoint pos)
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	m_contextMenu->popup(this->mapToGlobal(pos));
 }
 
diff --git a/pcsx2-qt/Debugger/MemoryViewWidget.cpp b/pcsx2-qt/Debugger/MemoryViewWidget.cpp
index bc0eff6125..926e9d9009 100644
--- a/pcsx2-qt/Debugger/MemoryViewWidget.cpp
+++ b/pcsx2-qt/Debugger/MemoryViewWidget.cpp
@@ -344,12 +344,18 @@ void MemoryViewWidget::paintEvent(QPaintEvent* event)
 
 void MemoryViewWidget::mousePressEvent(QMouseEvent* event)
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	m_table.SelectAt(event->pos());
 	repaint();
 }
 
 void MemoryViewWidget::customMenuRequested(QPoint pos)
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	if (!m_contextMenu)
 	{
 		m_contextMenu = new QMenu(this);
diff --git a/pcsx2-qt/Debugger/RegisterWidget.cpp b/pcsx2-qt/Debugger/RegisterWidget.cpp
index f09d5c85f0..2325cee76e 100644
--- a/pcsx2-qt/Debugger/RegisterWidget.cpp
+++ b/pcsx2-qt/Debugger/RegisterWidget.cpp
@@ -219,6 +219,9 @@ void RegisterWidget::wheelEvent(QWheelEvent* event)
 
 void RegisterWidget::customMenuRequested(QPoint pos)
 {
+	if (!m_cpu->isAlive())
+		return;
+
 	if (m_selectedRow > m_rowEnd) // Unsigned underflow; selectedRow will be > m_rowEnd (technically negative)
 		return;