diff --git a/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp b/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
index 116a1e08eb..11ff0c6cf8 100644
--- a/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
+++ b/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
@@ -78,7 +78,7 @@ InterfaceSettingsWidget::InterfaceSettingsWidget(SettingsDialog* dialog, QWidget
 		m_ui.inhibitScreensaver, tr("Inhibit Screensaver"), tr("Checked"),
 		tr("Prevents the screen saver from activating and the host from sleeping while emulation is running."));
 
-	if (AutoUpdaterDialog::isSupported())
+	if (!dialog->isPerGameSettings() && AutoUpdaterDialog::isSupported())
 	{
 		SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.autoUpdateEnabled, "AutoUpdater", "CheckAtStartup", true);
 		dialog->registerWidgetHelp(m_ui.autoUpdateEnabled, tr("Enable Automatic Update Check"), tr("Checked"),
@@ -104,6 +104,16 @@ InterfaceSettingsWidget::InterfaceSettingsWidget(SettingsDialog* dialog, QWidget
 	m_ui.discordPresence->setEnabled(false);
 #endif
 
+	if (dialog->isPerGameSettings())
+	{
+		// language/theme doesn't make sense to have in per-game settings
+		m_ui.verticalLayout->removeWidget(m_ui.preferencesGroup);
+		m_ui.preferencesGroup->hide();
+
+		// start paused doesn't make sense, because settings are applied after ELF load.
+		m_ui.pauseOnStart->setEnabled(false);
+	}
+
 	dialog->registerWidgetHelp(
 		m_ui.confirmShutdown, tr("Confirm Shutdown"), tr("Checked"),
 		tr("Determines whether a prompt will be displayed to confirm shutting down the virtual machine "
diff --git a/pcsx2-qt/Settings/InterfaceSettingsWidget.ui b/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
index b91fc0794a..5a69dfba2f 100644
--- a/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
+++ b/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
@@ -140,7 +140,7 @@
     </widget>
    </item>
    <item>
-    <widget class="QGroupBox" name="groupBox">
+    <widget class="QGroupBox" name="preferencesGroup">
      <property name="title">
       <string>Preferences</string>
      </property>
diff --git a/pcsx2-qt/Settings/SettingsDialog.cpp b/pcsx2-qt/Settings/SettingsDialog.cpp
index 825f6938ca..a34c0944fd 100644
--- a/pcsx2-qt/Settings/SettingsDialog.cpp
+++ b/pcsx2-qt/Settings/SettingsDialog.cpp
@@ -77,21 +77,7 @@ void SettingsDialog::setupUi(const GameList::Entry* game)
 	m_ui.setupUi(this);
 	setWindowFlags(windowFlags() & ~Qt::WindowContextHelpButtonHint);
 
-	// We don't include interface/game list/bios settings from per-game settings.
-	if (!isPerGameSettings())
-	{
-		addWidget(m_interface_settings = new InterfaceSettingsWidget(this, m_ui.settingsContainer), tr("Interface"),
-			QStringLiteral("settings-3-line"),
-			tr("<strong>Interface Settings</strong><hr>These options control how the software looks and behaves.<br><br>Mouse over an option for "
-			   "additional information."));
-		addWidget(m_game_list_settings = new GameListSettingsWidget(this, m_ui.settingsContainer), tr("Game List"),
-			QStringLiteral("folder-settings-line"),
-			tr("<strong>Game List Settings</strong><hr>The list above shows the directories which will be searched by PCSX2 to populate the game "
-			   "list. Search directories can be added, removed, and switched to recursive/non-recursive."));
-		addWidget(m_bios_settings = new BIOSSettingsWidget(this, m_ui.settingsContainer), tr("BIOS"), QStringLiteral("hard-drive-2-line"),
-			tr("<strong>BIOS Settings</strong><hr>Configure your BIOS here.<br><br>Mouse over an option for additional information."));
-	}
-	else
+	if (isPerGameSettings())
 	{
 		if (game)
 		{
@@ -102,6 +88,22 @@ void SettingsDialog::setupUi(const GameList::Entry* game)
 		m_ui.restoreDefaultsButton->setVisible(false);
 	}
 
+	addWidget(m_interface_settings = new InterfaceSettingsWidget(this, m_ui.settingsContainer), tr("Interface"),
+		QStringLiteral("settings-3-line"),
+		tr("<strong>Interface Settings</strong><hr>These options control how the software looks and behaves.<br><br>Mouse over an option for "
+		   "additional information."));
+
+	// We don't include game list/bios settings in per-game settings.
+	if (!isPerGameSettings())
+	{
+		addWidget(m_game_list_settings = new GameListSettingsWidget(this, m_ui.settingsContainer), tr("Game List"),
+			QStringLiteral("folder-settings-line"),
+			tr("<strong>Game List Settings</strong><hr>The list above shows the directories which will be searched by PCSX2 to populate the game "
+			   "list. Search directories can be added, removed, and switched to recursive/non-recursive."));
+		addWidget(m_bios_settings = new BIOSSettingsWidget(this, m_ui.settingsContainer), tr("BIOS"), QStringLiteral("hard-drive-2-line"),
+			tr("<strong>BIOS Settings</strong><hr>Configure your BIOS here.<br><br>Mouse over an option for additional information."));
+	}
+
 	// Common to both per-game and global settings.
 	addWidget(m_emulation_settings = new EmulationSettingsWidget(this, m_ui.settingsContainer), tr("Emulation"), QStringLiteral("dashboard-line"),
 		tr("<strong>Emulation Settings</strong><hr>These options determine the configuration of frame pacing and game settings.<br><br>Mouse over an option for additional information."));