diff --git a/cmake/ApiValidation.cmake b/cmake/ApiValidation.cmake
new file mode 100644
index 0000000000..a0b1c447db
--- /dev/null
+++ b/cmake/ApiValidation.cmake
@@ -0,0 +1,61 @@
+set(wx_sdl_c_code "
+#include <wx/setup.h>
+
+#if (wxUSE_LIBSDL != 0)
+#error cmake_WX_SDL
+#endif
+")
+
+set(wx_gtk3_c_code "
+#include <wx/setup.h>
+
+#ifdef __WXGTK3__
+#error cmake_WX_GTK3
+#endif
+")
+
+function(WX_vs_SDL)
+    file(WRITE "${CMAKE_BINARY_DIR}/wx_sdl.c" "${wx_sdl_c_code}")
+    enable_language(C)
+
+    try_run(
+            run_result_unused
+            compile_result_unused
+            "${CMAKE_BINARY_DIR}"
+            "${CMAKE_BINARY_DIR}/wx_sdl.c"
+            COMPILE_OUTPUT_VARIABLE OUT
+            CMAKE_FLAGS "-DINCLUDE_DIRECTORIES:STRING=${wxWidgets_INCLUDE_DIRS}"
+        )
+
+    if (${OUT} MATCHES "cmake_WX_SDL" AND SDL2_API)
+        message(FATAL_ERROR "WxWidget is linked to SDL (wxUSE_LIBSDL) and it is likely SDL1.2.
+        Unfortunately you try to build PCSX2 with SDL2 support which is not compatible
+        Please use -DSDL2_API=FALSE")
+    endif()
+
+endfunction()
+
+function(WX_vs_GTK3)
+    file(WRITE "${CMAKE_BINARY_DIR}/wx_gtk3.c" "${wx_gtk3_c_code}")
+    enable_language(C)
+
+    try_run(
+            run_result_unused
+            compile_result_unused
+            "${CMAKE_BINARY_DIR}"
+            "${CMAKE_BINARY_DIR}/wx_gtk3.c"
+            COMPILE_OUTPUT_VARIABLE OUT
+            CMAKE_FLAGS "-DINCLUDE_DIRECTORIES:STRING=${wxWidgets_INCLUDE_DIRS}"
+        )
+
+    if (${OUT} MATCHES "cmake_WX_GTK3")
+        if (NOT GTK3_API)
+            message(FATAL_ERROR "Your current WxWidget version requires GTK3. Please use -DGTK3_API=TRUE option")
+        endif()
+    else()
+        if (GTK3_API)
+            message(FATAL_ERROR "Your current WxWidget version doesn't support GTK3. Please use -DGTK3_API=FALSE option")
+        endif()
+    endif()
+
+endfunction()
diff --git a/cmake/SearchForStuff.cmake b/cmake/SearchForStuff.cmake
index 5e3d0278ab..07feef4efd 100644
--- a/cmake/SearchForStuff.cmake
+++ b/cmake/SearchForStuff.cmake
@@ -140,3 +140,11 @@ include_directories(${CMAKE_SOURCE_DIR}/common/include
                     # File generated by Cmake
                     ${CMAKE_BINARY_DIR}/common/include
                     )
+
+#----------------------------------------
+# Check correctness of the parameter
+# Note: wxWidgets_INCLUDE_DIRS must be defined
+#----------------------------------------
+include(ApiValidation)
+WX_vs_SDL()
+WX_vs_GTK3()