diff --git a/pcsx2/gui/Saveslots.h b/pcsx2/gui/Saveslots.h
index 0eacfc05d4..8dc30a7df2 100644
--- a/pcsx2/gui/Saveslots.h
+++ b/pcsx2/gui/Saveslots.h
@@ -36,6 +36,8 @@
 //#define SAVESLOT_LOGS
 #endif
 
+extern wxString DiscSerial;
+
 class Saveslot
 {
 public:
@@ -43,6 +45,7 @@ public:
 	bool empty;
 	wxDateTime updated;
 	u32 crc;
+	wxString serialName;
 	bool menu_update, invalid_cache;
 
 	Saveslot()
@@ -51,6 +54,7 @@ public:
 		empty = true;
 		updated = wxInvalidDateTime;
 		crc = ElfCRC;
+		serialName = DiscSerial;
 		menu_update = false;
 		invalid_cache = true;
 	}
@@ -61,6 +65,7 @@ public:
 		empty = true;
 		updated = wxInvalidDateTime;
 		crc = ElfCRC;
+		serialName = DiscSerial;
 		menu_update = false;
 		invalid_cache = true;
 	}
@@ -82,6 +87,7 @@ public:
 		empty = !isUsed();
 		updated = GetTimestamp();
 		crc = ElfCRC;
+		serialName = DiscSerial;
 		invalid_cache = false;
 	}
 
diff --git a/pcsx2/gui/UpdateUI.cpp b/pcsx2/gui/UpdateUI.cpp
index 33f259a9dd..f9edebcb77 100644
--- a/pcsx2/gui/UpdateUI.cpp
+++ b/pcsx2/gui/UpdateUI.cpp
@@ -50,8 +50,8 @@ static void _SaveLoadStuff(bool enabled)
 		int load_menu_item = MenuId_State_Load01 + i + 1;
 		int save_menu_item = MenuId_State_Save01 + i + 1;
 		
-		// We need to reload the file information if the crc changed.
-		if (saveslot_cache[i].crc != ElfCRC) saveslot_cache[i].invalid_cache = true;
+		// We need to reload the file information if the crc or serial # changed.
+		if ((saveslot_cache[i].crc != ElfCRC)|| (saveslot_cache[i].serialName != DiscSerial)) saveslot_cache[i].invalid_cache = true;
 
 		// Either the cache needs updating, or the menu items do, or both.
 		if (saveslot_cache[i].menu_update || saveslot_cache[i].invalid_cache)