diff --git a/pcsx2/gui/Dialogs/GSDumpDialog.cpp b/pcsx2/gui/Dialogs/GSDumpDialog.cpp
index 02fe6c37b2..146be6ae69 100644
--- a/pcsx2/gui/Dialogs/GSDumpDialog.cpp
+++ b/pcsx2/gui/Dialogs/GSDumpDialog.cpp
@@ -68,6 +68,7 @@ Dialogs::GSDumpDialog::GSDumpDialog(wxWindow* parent)
 	, m_step(new wxButton(this, ID_RUN_STEP, _("Step"), wxDefaultPosition, wxSize(150, 50)))
 	, m_selection(new wxButton(this, ID_RUN_CURSOR, _("Run to Selection"), wxDefaultPosition, wxSize(150, 50)))
 	, m_vsync(new wxButton(this, ID_RUN_VSYNC, _("Go to next VSync"), wxDefaultPosition, wxSize(150, 50)))
+	, m_settings(new wxButton(this, ID_SETTINGS, _("Open GS Settings"), wxDefaultPosition, wxSize(150, 50)))
 	, m_thread(std::make_unique<GSThread>(this))
 	, m_run(new wxButton(this, ID_RUN_DUMP, _("Run"), wxDefaultPosition, wxSize(150, 100)))
 {
@@ -95,6 +96,7 @@ Dialogs::GSDumpDialog::GSDumpDialog(wxWindow* parent)
 	dbg_actions->Add(m_step, StdExpand());
 	dbg_actions->Add(m_selection, StdExpand());
 	dbg_actions->Add(m_vsync, StdExpand());
+	dbg_actions->Add(m_settings, StdExpand());
 	gif->Add(new wxStaticText(this, wxID_ANY, _("Packet Content")));
 	gif->Add(m_gif_packet, StdExpand());
 
@@ -135,6 +137,7 @@ Dialogs::GSDumpDialog::GSDumpDialog(wxWindow* parent)
 	Bind(wxEVT_BUTTON, &Dialogs::GSDumpDialog::StepPacket, this, ID_RUN_STEP);
 	Bind(wxEVT_BUTTON, &Dialogs::GSDumpDialog::ToCursor, this, ID_RUN_CURSOR);
 	Bind(wxEVT_BUTTON, &Dialogs::GSDumpDialog::ToVSync, this, ID_RUN_VSYNC);
+	Bind(wxEVT_BUTTON, &Dialogs::GSDumpDialog::OpenSettings, this, ID_SETTINGS);
 	Bind(wxEVT_TREE_SEL_CHANGED, &Dialogs::GSDumpDialog::ParsePacket, this, ID_SEL_PACKET);
 	Bind(wxEVT_CHECKBOX, &Dialogs::GSDumpDialog::CheckDebug, this, ID_DEBUG_MODE);
 	Bind(EVT_CLOSE_DUMP, &Dialogs::GSDumpDialog::CloseDump, this);
@@ -270,6 +273,11 @@ void Dialogs::GSDumpDialog::ToVSync(wxCommandEvent& event)
 	}
 }
 
+void Dialogs::GSDumpDialog::OpenSettings(wxCommandEvent& event)
+{
+	GetCorePlugins().Configure(PluginId_GS);
+}
+
 void Dialogs::GSDumpDialog::ToStart(wxCommandEvent& event)
 {
 	m_gif_list->SelectItem(m_gif_items[0]);
diff --git a/pcsx2/gui/Dialogs/ModalPopups.h b/pcsx2/gui/Dialogs/ModalPopups.h
index 13fa96455e..44f1fb24ec 100644
--- a/pcsx2/gui/Dialogs/ModalPopups.h
+++ b/pcsx2/gui/Dialogs/ModalPopups.h
@@ -161,6 +161,7 @@ namespace Dialogs
 		wxButton* m_step;
 		wxButton* m_selection;
 		wxButton* m_vsync;
+		wxButton* m_settings;
 		wxButton* m_run;
 		long m_focused_dump;
 		wxFileSystemWatcher m_fs_watcher;
@@ -172,6 +173,7 @@ namespace Dialogs
 		void StepPacket(wxCommandEvent& event);
 		void ToCursor(wxCommandEvent& event);
 		void ToVSync(wxCommandEvent& event);
+		void OpenSettings(wxCommandEvent& event);
 		void ParsePacket(wxTreeEvent& event);
 		void CheckDebug(wxCommandEvent& event);
 		void PathChanged(wxFileSystemWatcherEvent& event);
@@ -184,7 +186,8 @@ namespace Dialogs
 			ID_RUN_CURSOR,
 			ID_RUN_VSYNC,
 			ID_SEL_PACKET,
-			ID_DEBUG_MODE
+			ID_DEBUG_MODE,
+			ID_SETTINGS
 		};
 		enum GSType : u8
 		{
diff --git a/pcsx2/gui/MainMenuClicks.cpp b/pcsx2/gui/MainMenuClicks.cpp
index 5d3042ac0a..68cbea51a4 100644
--- a/pcsx2/gui/MainMenuClicks.cpp
+++ b/pcsx2/gui/MainMenuClicks.cpp
@@ -165,6 +165,11 @@ void MainEmuFrame::Menu_ResetAllSettings_Click(wxCommandEvent& event)
 //   (anything else) - Standard swap, no reset.  (hotswap!)
 wxWindowID SwapOrReset_Iso(wxWindow* owner, IScopedCoreThread& core_control, const wxString& isoFilename, const wxString& descpart1)
 {
+	if (GSDump::isRunning)
+	{
+		wxMessageBox("Please close the GS debugger first before playing a game", _("GS Debugger"), wxICON_ERROR);
+		return wxID_CANCEL;
+	}
 	wxWindowID result = wxID_CANCEL;
 
 	if ((g_Conf->CdvdSource == CDVD_SourceType::Iso) && (isoFilename == g_Conf->CurrentIso))
@@ -222,6 +227,11 @@ wxWindowID SwapOrReset_Iso(wxWindow* owner, IScopedCoreThread& core_control, con
 //   (anything else) - Standard swap, no reset.  (hotswap!)
 wxWindowID SwapOrReset_Disc(wxWindow* owner, IScopedCoreThread& core, const wxString driveLetter)
 {
+	if (GSDump::isRunning)
+	{
+		wxMessageBox("Please close the GS debugger first before playing a game", _("GS Debugger"), wxICON_ERROR);
+		return wxID_CANCEL;
+	}
 	wxWindowID result = wxID_CANCEL;
 
 	if ((g_Conf->CdvdSource == CDVD_SourceType::Disc) && (driveLetter == g_Conf->Folders.RunDisc.GetPath()))
@@ -270,6 +280,11 @@ wxWindowID SwapOrReset_Disc(wxWindow* owner, IScopedCoreThread& core, const wxSt
 
 wxWindowID SwapOrReset_CdvdSrc(wxWindow* owner, CDVD_SourceType newsrc)
 {
+	if (GSDump::isRunning)
+	{
+		wxMessageBox("Please close the GS debugger first before playing a game", _("GS Debugger"), wxICON_ERROR);
+		return wxID_CANCEL;
+	}
 	if (newsrc == g_Conf->CdvdSource)
 		return wxID_CANCEL;
 	wxWindowID result = wxID_CANCEL;
@@ -406,6 +421,11 @@ bool MainEmuFrame::_DoSelectELFBrowser()
 
 void MainEmuFrame::_DoBootCdvd()
 {
+	if (GSDump::isRunning)
+	{
+		wxMessageBox("Please close the GS debugger first before playing a game", _("GS Debugger"), wxICON_ERROR);
+		return;
+	}
 	ScopedCoreThreadPause paused_core;
 
 	if (g_Conf->CdvdSource == CDVD_SourceType::Iso)
@@ -823,6 +843,11 @@ void MainEmuFrame::Menu_SysShutdown_Click(wxCommandEvent& event)
 
 void MainEmuFrame::Menu_ConfigPlugin_Click(wxCommandEvent& event)
 {
+	if (GSDump::isRunning)
+	{
+		wxMessageBox("Please open the settings window from the main GS Debugger window", _("GS Debugger"), wxICON_ERROR);
+		return;
+	}
 	const int eventId = event.GetId() - MenuId_PluginBase_Settings;
 
 	PluginsEnum_t pid = (PluginsEnum_t)(eventId / PluginMenuId_Interval);