diff --git a/pcsx2/GS/Renderers/Metal/GSDeviceMTL.mm b/pcsx2/GS/Renderers/Metal/GSDeviceMTL.mm
index 758e6889f4..b8e0318378 100644
--- a/pcsx2/GS/Renderers/Metal/GSDeviceMTL.mm
+++ b/pcsx2/GS/Renderers/Metal/GSDeviceMTL.mm
@@ -2114,7 +2114,7 @@ void GSDeviceMTL::MREInitHWDraw(GSHWDrawConfig& config, const Map& verts)
 
 void GSDeviceMTL::RenderHW(GSHWDrawConfig& config)
 { @autoreleasepool {
-	if (config.tex && config.ds == config.tex)
+	if (config.tex && (config.ds == config.tex || config.rt == config.tex))
 		EndRenderPass(); // Barrier
 
 	size_t vertsize = config.nverts * sizeof(*config.verts);
diff --git a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
index b485149ac9..8ae9200c95 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
+++ b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
@@ -2496,12 +2496,6 @@ void GSDeviceOGL::RenderHW(GSHWDrawConfig& config)
 			config.drawarea.width(), config.drawarea.height());
 		CopyRect(hdr_rt ? hdr_rt : config.rt, draw_rt_clone, config.drawarea, config.drawarea.left, config.drawarea.top);
 	}
-	else if (config.tex && config.tex == config.ds)
-	{
-		// Ensure all depth writes are finished before sampling
-		GL_INS("Texture barrier to flush depth before reading");
-		glTextureBarrier();
-	}
 
 	IASetVertexBuffer(config.verts, config.nverts);
 	if (config.vs.expand != GSHWDrawConfig::VSExpand::None && !GLAD_GL_ARB_shader_draw_parameters)
@@ -2563,6 +2557,15 @@ void GSDeviceOGL::RenderHW(GSHWDrawConfig& config)
 
 	SetupPipeline(psel);
 
+	const bool check_barrier = !(config.require_one_barrier && !m_features.texture_barrier);
+
+	// Be careful of the rt already being bound and the blend using the RT without a barrier.
+	if (check_barrier && ((config.tex && (config.tex == config.ds || config.tex == config.rt)) || ((psel.ps.IsFeedbackLoop() || psel.ps.blend_c == 1) && GLState::rt == config.rt)))
+	{
+		// Ensure all depth writes are finished before sampling
+		GL_INS("Texture barrier to flush depth or rt before reading");
+		glTextureBarrier();
+	}
 	// additional non-pipeline config stuff
 	const bool point_size_enabled = config.vs.point_size;
 	if (GLState::point_size != point_size_enabled)
diff --git a/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp b/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
index 086779191b..d82df886f6 100644
--- a/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
+++ b/pcsx2/GS/Renderers/Vulkan/GSDeviceVK.cpp
@@ -5641,6 +5641,10 @@ void GSDeviceVK::RenderHW(GSHWDrawConfig& config)
 	PipelineSelector& pipe = m_pipeline_selector;
 	UpdateHWPipelineSelector(config, pipe);
 
+	// If we don't have a barrier but the texture was drawn to last draw, end the pass to insert a barrier.
+	if (InRenderPass() && !pipe.IsRTFeedbackLoop() && (config.tex == m_current_render_target || config.tex == m_current_depth_target))
+		EndRenderPass();
+
 	// now blit the hdr texture back to the original target
 	if (hdr_rt)
 	{