diff --git a/pcsx2/VMManager.cpp b/pcsx2/VMManager.cpp
index 88e5b48d1b..b66f8744aa 100644
--- a/pcsx2/VMManager.cpp
+++ b/pcsx2/VMManager.cpp
@@ -2210,7 +2210,10 @@ void VMManager::ReloadPatches(bool reload_files, bool reload_enabled_list, bool
 void VMManager::EnforceAchievementsChallengeModeSettings()
 {
 	if (!Achievements::ChallengeModeActive())
+	{
+		Host::RemoveKeyedOSDMessage("ChallengeDisableCheats");
 		return;
+	}
 
 	static constexpr auto ClampSpeed = [](float& rate) {
 		if (rate > 0.0f && rate < 1.0f)