diff --git a/pcsx2-qt/Settings/ControllerSettingsDialog.cpp b/pcsx2-qt/Settings/ControllerSettingsDialog.cpp
index 7b606edea4..baf9fcf1db 100644
--- a/pcsx2-qt/Settings/ControllerSettingsDialog.cpp
+++ b/pcsx2-qt/Settings/ControllerSettingsDialog.cpp
@@ -128,6 +128,7 @@ void ControllerSettingsDialog::onNewProfileClicked()
 			// from global
 			auto lock = Host::GetSettingsLock();
 			PAD::CopyConfiguration(&temp_si, *Host::Internal::GetBaseSettingsLayer(), true, true, false);
+			USB::CopyConfiguration(&temp_si, *Host::Internal::GetBaseSettingsLayer(), true, true);
 		}
 		else
 		{
@@ -135,6 +136,7 @@ void ControllerSettingsDialog::onNewProfileClicked()
 			const bool copy_hotkey_bindings = m_profile_interface->GetBoolValue("Pad", "UseProfileHotkeyBindings", false);
 			temp_si.SetBoolValue("Pad", "UseProfileHotkeyBindings", copy_hotkey_bindings);
 			PAD::CopyConfiguration(&temp_si, *m_profile_interface, true, true, copy_hotkey_bindings);
+			USB::CopyConfiguration(&temp_si, *m_profile_interface, true, true);
 		}
 	}
 
@@ -163,6 +165,7 @@ void ControllerSettingsDialog::onLoadProfileClicked()
 	{
 		auto lock = Host::GetSettingsLock();
 		PAD::CopyConfiguration(Host::Internal::GetBaseSettingsLayer(), *m_profile_interface, true, true, false);
+		USB::CopyConfiguration(Host::Internal::GetBaseSettingsLayer(), *m_profile_interface, true, true);
 	}
 	Host::CommitBaseSettingChanges();
 
diff --git a/pcsx2/Config.h b/pcsx2/Config.h
index 6a6e8969fe..e292c15a85 100644
--- a/pcsx2/Config.h
+++ b/pcsx2/Config.h
@@ -66,6 +66,10 @@ struct SettingInfo
 	float FloatMinValue() const;
 	float FloatMaxValue() const;
 	float FloatStepValue() const;
+
+	void SetDefaultValue(SettingsInterface* si, const char* section, const char* key) const;
+	void CopyValue(SettingsInterface* dest_si, const SettingsInterface& src_si,
+		const char* section, const char* key) const;
 };
 
 enum class GenericInputBinding : u8;
diff --git a/pcsx2/ImGui/FullscreenUI.cpp b/pcsx2/ImGui/FullscreenUI.cpp
index e72d08977c..e413a7009f 100644
--- a/pcsx2/ImGui/FullscreenUI.cpp
+++ b/pcsx2/ImGui/FullscreenUI.cpp
@@ -3590,6 +3590,7 @@ void FullscreenUI::CopyGlobalControllerSettingsToGame()
 	SettingsInterface* ssi = GetEditingSettingsInterface(false);
 
 	PAD::CopyConfiguration(dsi, *ssi, true, true, false);
+	USB::CopyConfiguration(dsi, *ssi, true, true);
 	SetSettingsChanged(dsi);
 
 	ShowToast(std::string(), "Per-game controller configuration initialized with global settings.");
@@ -3601,6 +3602,7 @@ void FullscreenUI::ResetControllerSettings()
 
 	PAD::SetDefaultControllerConfig(*dsi);
 	PAD::SetDefaultHotkeyConfig(*dsi);
+	USB::SetDefaultConfiguration(dsi);
 	ShowToast(std::string(), "Controller settings reset to default.");
 }
 
@@ -3633,6 +3635,7 @@ void FullscreenUI::DoLoadInputProfile()
 			auto lock = Host::GetSettingsLock();
 			SettingsInterface* dsi = GetEditingSettingsInterface();
 			PAD::CopyConfiguration(dsi, ssi, true, true, IsEditingGameSettings(dsi));
+			USB::CopyConfiguration(dsi, ssi, true, true);
 			SetSettingsChanged(dsi);
 			ShowToast(std::string(), fmt::format("Input profile '{}' loaded.", title));
 			CloseChoiceDialog();
@@ -3646,6 +3649,7 @@ void FullscreenUI::DoSaveInputProfile(const std::string& name)
 	auto lock = Host::GetSettingsLock();
 	SettingsInterface* ssi = GetEditingSettingsInterface();
 	PAD::CopyConfiguration(&dsi, *ssi, true, true, IsEditingGameSettings(ssi));
+	USB::CopyConfiguration(&dsi, *ssi, true, true);
 	if (dsi.Save())
 		ShowToast(std::string(), fmt::format("Input profile '{}' saved.", name));
 	else
diff --git a/pcsx2/PAD/Host/PAD.cpp b/pcsx2/PAD/Host/PAD.cpp
index 014ce03b77..b19c293f02 100644
--- a/pcsx2/PAD/Host/PAD.cpp
+++ b/pcsx2/PAD/Host/PAD.cpp
@@ -287,26 +287,7 @@ void PAD::SetDefaultControllerConfig(SettingsInterface& si)
 			for (u32 i = 0; i < ci->num_settings; i++)
 			{
 				const SettingInfo& csi = ci->settings[i];
-				switch (csi.type)
-				{
-					case SettingInfo::Type::Boolean:
-						si.SetBoolValue(section.c_str(), csi.name, csi.BooleanDefaultValue());
-						break;
-					case SettingInfo::Type::Integer:
-					case SettingInfo::Type::IntegerList:
-						si.SetIntValue(section.c_str(), csi.name, csi.IntegerDefaultValue());
-						break;
-					case SettingInfo::Type::Float:
-						si.SetFloatValue(section.c_str(), csi.name, csi.FloatDefaultValue());
-						break;
-					case SettingInfo::Type::String:
-					case SettingInfo::Type::StringList:
-					case SettingInfo::Type::Path:
-						si.SetStringValue(section.c_str(), csi.name, csi.StringDefaultValue());
-						break;
-					default:
-						break;
-				}
+				csi.SetDefaultValue(&si, section.c_str(), csi.name);
 			}
 		}
 	}
@@ -583,26 +564,7 @@ void PAD::CopyConfiguration(SettingsInterface* dest_si, const SettingsInterface&
 			for (u32 i = 0; i < info->num_settings; i++)
 			{
 				const SettingInfo& csi = info->settings[i];
-				switch (csi.type)
-				{
-					case SettingInfo::Type::Boolean:
-						dest_si->CopyBoolValue(src_si, section.c_str(), csi.name);
-						break;
-					case SettingInfo::Type::Integer:
-					case SettingInfo::Type::IntegerList:
-						dest_si->CopyIntValue(src_si, section.c_str(), csi.name);
-						break;
-					case SettingInfo::Type::Float:
-						dest_si->CopyFloatValue(src_si, section.c_str(), csi.name);
-						break;
-					case SettingInfo::Type::String:
-					case SettingInfo::Type::StringList:
-					case SettingInfo::Type::Path:
-						dest_si->CopyStringValue(src_si, section.c_str(), csi.name);
-						break;
-					default:
-						break;
-				}
+				csi.CopyValue(dest_si, src_si, section.c_str(), csi.name);
 			}
 		}
 	}
diff --git a/pcsx2/Pcsx2Config.cpp b/pcsx2/Pcsx2Config.cpp
index 7ccc48b76e..1285b94b0b 100644
--- a/pcsx2/Pcsx2Config.cpp
+++ b/pcsx2/Pcsx2Config.cpp
@@ -88,6 +88,55 @@ float SettingInfo::FloatStepValue() const
 	return step_value ? StringUtil::FromChars<float>(step_value).value_or(fallback_value) : fallback_value;
 }
 
+void SettingInfo::SetDefaultValue(SettingsInterface* si, const char* section, const char* key) const
+{
+	switch (type)
+	{
+		case SettingInfo::Type::Boolean:
+			si->SetBoolValue(section, key, BooleanDefaultValue());
+			break;
+		case SettingInfo::Type::Integer:
+		case SettingInfo::Type::IntegerList:
+			si->SetIntValue(section, key, IntegerDefaultValue());
+			break;
+		case SettingInfo::Type::Float:
+			si->SetFloatValue(section, key, FloatDefaultValue());
+			break;
+		case SettingInfo::Type::String:
+		case SettingInfo::Type::StringList:
+		case SettingInfo::Type::Path:
+			si->SetStringValue(section, key, StringDefaultValue());
+			break;
+		default:
+			break;
+	}
+}
+
+void SettingInfo::CopyValue(SettingsInterface* dest_si, const SettingsInterface& src_si,
+	const char* section, const char* key) const
+{
+	switch (type)
+	{
+		case SettingInfo::Type::Boolean:
+			dest_si->CopyBoolValue(src_si, section, key);
+			break;
+		case SettingInfo::Type::Integer:
+		case SettingInfo::Type::IntegerList:
+			dest_si->CopyIntValue(src_si, section, key);
+			break;
+		case SettingInfo::Type::Float:
+			dest_si->CopyFloatValue(src_si, section, key);
+			break;
+		case SettingInfo::Type::String:
+		case SettingInfo::Type::StringList:
+		case SettingInfo::Type::Path:
+			dest_si->CopyStringValue(src_si, section, key);
+			break;
+		default:
+			break;
+	}
+}
+
 namespace EmuFolders
 {
 	std::string AppRoot;
diff --git a/pcsx2/USB/USB.cpp b/pcsx2/USB/USB.cpp
index 1511baadb8..427c543412 100644
--- a/pcsx2/USB/USB.cpp
+++ b/pcsx2/USB/USB.cpp
@@ -749,8 +749,8 @@ bool USB::MapDevice(SettingsInterface& si, u32 port, const std::vector<std::pair
 
 void USB::ClearPortBindings(SettingsInterface& si, u32 port)
 {
-	const std::string section(GetConfigSection(port));
-	const std::string type(GetConfigDevice(si, port));
+	const std::string section = GetConfigSection(port);
+	const std::string type = GetConfigDevice(si, port);
 	const u32 subtype = GetConfigSubType(si, port, type);
 	const DeviceProxy* dev = RegisterDevice::instance().Device(type);
 	if (!dev)
@@ -760,6 +760,47 @@ void USB::ClearPortBindings(SettingsInterface& si, u32 port)
 		si.DeleteValue(section.c_str(), GetConfigSubKey(type, bi.name).c_str());
 }
 
+void USB::CopyConfiguration(SettingsInterface* dest_si, const SettingsInterface& src_si,
+	bool copy_devices, bool copy_bindings)
+{
+	for (u32 port = 0; port < NUM_PORTS; port++)
+	{
+		const std::string section = GetConfigSection(port);
+		const std::string type = GetConfigDevice(src_si, port);
+		const u32 subtype = GetConfigSubType(src_si, port, type);
+		const DeviceProxy* dev = RegisterDevice::instance().Device(type);
+
+		if (copy_devices)
+		{
+			dest_si->CopyStringValue(src_si, section.c_str(), "Type");
+			if (dev)
+			{
+				dest_si->CopyUIntValue(src_si, section.c_str(), fmt::format("{}_subtype", type).c_str());
+
+				for (const SettingInfo& si : dev->Settings(subtype))
+					si.CopyValue(dest_si, src_si, section.c_str(), GetConfigSubKey(type, si.name).c_str());
+			}
+		}
+
+		if (copy_bindings && dev)
+		{
+			for (const InputBindingInfo& bi : dev->Bindings(subtype))
+				dest_si->CopyStringValue(src_si, section.c_str(), GetConfigSubKey(type, bi.name).c_str());
+		}
+	}
+}
+
+void USB::SetDefaultConfiguration(SettingsInterface* si)
+{
+	for (u32 port = 0; port < NUM_PORTS; port++)
+	{
+		const std::string section = GetConfigSection(port);
+
+		si->ClearSection(section.c_str());
+		si->SetStringValue(section.c_str(), "Type", "None");
+	}
+}
+
 void USB::CheckForConfigChanges(const Pcsx2Config& old_config)
 {
 	static_assert(Pcsx2Config::USBOptions::NUM_PORTS == NUM_PORTS);
diff --git a/pcsx2/USB/USB.h b/pcsx2/USB/USB.h
index dd818f6180..eeb40f3631 100644
--- a/pcsx2/USB/USB.h
+++ b/pcsx2/USB/USB.h
@@ -70,6 +70,13 @@ namespace USB
 	/// Clears all bindings for a given port.
 	void ClearPortBindings(SettingsInterface& si, u32 port);
 
+	/// Copies configuration between two profiles.
+	void CopyConfiguration(SettingsInterface* dest_si, const SettingsInterface& src_si, bool copy_devices = true,
+		bool copy_bindings = true);
+
+	/// Resets configuration for all ports.
+	void SetDefaultConfiguration(SettingsInterface* si);
+
 	/// Identifies any device/subtype changes and recreates devices.
 	void CheckForConfigChanges(const Pcsx2Config& old_config);
 
diff --git a/pcsx2/VMManager.cpp b/pcsx2/VMManager.cpp
index 4f32030854..fbe099c024 100644
--- a/pcsx2/VMManager.cpp
+++ b/pcsx2/VMManager.cpp
@@ -443,7 +443,10 @@ void VMManager::SetDefaultSettings(
 		LogSink::SetDefaultLoggingSettings(si);
 	}
 	if (controllers)
+	{
 		PAD::SetDefaultControllerConfig(si);
+		USB::SetDefaultConfiguration(&si);
+	}
 	if (hotkeys)
 		PAD::SetDefaultHotkeyConfig(si);
 	if (ui)