diff --git a/pcsx2/GS/GSState.cpp b/pcsx2/GS/GSState.cpp
index a48d693705..0c0d2101c1 100644
--- a/pcsx2/GS/GSState.cpp
+++ b/pcsx2/GS/GSState.cpp
@@ -3099,7 +3099,7 @@ __forceinline void GSState::VertexKick(u32 skip)
 
 	ASSERT(m_vertex.tail < m_vertex.maxcount + 3);
 
-	if (auto_flush && m_index.tail >= 0 && ((m_vertex.tail + 1) - m_vertex.head) >= n)
+	if (auto_flush && m_index.tail > 0 && ((m_vertex.tail + 1) - m_vertex.head) >= n)
 	{
 		HandleAutoFlush();
 	}
diff --git a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
index 27e6b176a9..92d82f8836 100644
--- a/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
+++ b/pcsx2/GS/Renderers/HW/GSRendererHW.cpp
@@ -900,7 +900,7 @@ void GSRendererHW::SwSpriteRender()
 
 	const bool alpha_blending_enabled = PRIM->ABE;
 
-	const GSVertex& v = m_vertex.buff[m_index.buff[m_index.tail - 1]]; // Last vertex.
+	const GSVertex& v = m_index.tail > 0 ? m_vertex.buff[m_index.buff[m_index.tail - 1]] : GSVertex(); // Last vertex if any.
 	const GSVector4i vc = GSVector4i(v.RGBAQ.R, v.RGBAQ.G, v.RGBAQ.B, v.RGBAQ.A) // 0x000000AA000000BB000000GG000000RR
 							  .ps32(); // 0x00AA00BB00GG00RR00AA00BB00GG00RR