diff --git a/pcsx2/CMakeLists.txt b/pcsx2/CMakeLists.txt
index 6c45e6c177..992f253e34 100644
--- a/pcsx2/CMakeLists.txt
+++ b/pcsx2/CMakeLists.txt
@@ -241,6 +241,7 @@ set(pcsx2Headers
 	R5900.h
 	R5900OpcodeTables.h
 	SaveState.h
+	ShaderCacheVersion.h
 	Sifcmd.h
 	Sif.h
 	SingleRegisterTypes.h
diff --git a/pcsx2/Frontend/VulkanHostDisplay.cpp b/pcsx2/Frontend/VulkanHostDisplay.cpp
index 75847d224e..2cefb50225 100644
--- a/pcsx2/Frontend/VulkanHostDisplay.cpp
+++ b/pcsx2/Frontend/VulkanHostDisplay.cpp
@@ -1,6 +1,7 @@
 #include "PrecompiledHeader.h"
 
 #include "VulkanHostDisplay.h"
+#include "ShaderCacheVersion.h"
 #include "common/Align.h"
 #include "common/Assertions.h"
 #include "common/Console.h"
@@ -15,8 +16,6 @@
 #include "imgui_impl_vulkan.h"
 #include <array>
 
-static constexpr u32 SHADER_CACHE_VERSION = 4;
-
 class VulkanHostDisplayTexture : public HostDisplayTexture
 {
 public:
diff --git a/pcsx2/GS/Renderers/DX11/GSDevice11.cpp b/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
index 97cb387c28..e197858f68 100644
--- a/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
+++ b/pcsx2/GS/Renderers/DX11/GSDevice11.cpp
@@ -22,6 +22,7 @@
 #include "GS/GSUtil.h"
 #include "Host.h"
 #include "HostDisplay.h"
+#include "ShaderCacheVersion.h"
 #include "common/StringUtil.h"
 #include <fstream>
 #include <sstream>
@@ -91,14 +92,14 @@ bool GSDevice11::Create()
 
 	if (!GSConfig.DisableShaderCache)
 	{
-		if (!m_shader_cache.Open(EmuFolders::Cache, m_dev->GetFeatureLevel(), SHADER_VERSION, GSConfig.UseDebugDevice))
+		if (!m_shader_cache.Open(EmuFolders::Cache, m_dev->GetFeatureLevel(), SHADER_CACHE_VERSION, GSConfig.UseDebugDevice))
 		{
 			Console.Warning("Shader cache failed to open.");
 		}
 	}
 	else
 	{
-		m_shader_cache.Open({}, m_dev->GetFeatureLevel(), SHADER_VERSION, GSConfig.UseDebugDevice);
+		m_shader_cache.Open({}, m_dev->GetFeatureLevel(), SHADER_CACHE_VERSION, GSConfig.UseDebugDevice);
 		Console.WriteLn("Not using shader cache.");
 	}
 
diff --git a/pcsx2/GS/Renderers/DX11/GSDevice11.h b/pcsx2/GS/Renderers/DX11/GSDevice11.h
index 3194eb1cc4..0875f4d238 100644
--- a/pcsx2/GS/Renderers/DX11/GSDevice11.h
+++ b/pcsx2/GS/Renderers/DX11/GSDevice11.h
@@ -108,9 +108,6 @@ public:
 	};
 
 private:
-	// Increment this constant whenever shaders change, to invalidate user's shader cache.
-	static constexpr u32 SHADER_VERSION = 1;
-
 	static constexpr u32 MAX_TEXTURES = 4;
 	static constexpr u32 MAX_SAMPLERS = 2;
 
diff --git a/pcsx2/GS/Renderers/DX12/GSDevice12.cpp b/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
index 2893b5dd65..30d2c933a6 100644
--- a/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
+++ b/pcsx2/GS/Renderers/DX12/GSDevice12.cpp
@@ -29,6 +29,7 @@
 #include "GS/GSUtil.h"
 #include "Host.h"
 #include "HostDisplay.h"
+#include "ShaderCacheVersion.h"
 #include <sstream>
 #include <limits>
 
@@ -113,14 +114,14 @@ bool GSDevice12::Create()
 
 	if (!GSConfig.DisableShaderCache)
 	{
-		if (!m_shader_cache.Open(EmuFolders::Cache, g_d3d12_context->GetFeatureLevel(), SHADER_VERSION, GSConfig.UseDebugDevice))
+		if (!m_shader_cache.Open(EmuFolders::Cache, g_d3d12_context->GetFeatureLevel(), SHADER_CACHE_VERSION, GSConfig.UseDebugDevice))
 		{
 			Console.Warning("Shader cache failed to open.");
 		}
 	}
 	else
 	{
-		m_shader_cache.Open({}, g_d3d12_context->GetFeatureLevel(), SHADER_VERSION, GSConfig.UseDebugDevice);
+		m_shader_cache.Open({}, g_d3d12_context->GetFeatureLevel(), SHADER_CACHE_VERSION, GSConfig.UseDebugDevice);
 		Console.WriteLn("Not using shader cache.");
 	}
 
diff --git a/pcsx2/GS/Renderers/DX12/GSDevice12.h b/pcsx2/GS/Renderers/DX12/GSDevice12.h
index 899fcb0eca..942d8c803b 100644
--- a/pcsx2/GS/Renderers/DX12/GSDevice12.h
+++ b/pcsx2/GS/Renderers/DX12/GSDevice12.h
@@ -133,8 +133,6 @@ public:
 	};
 
 private:
-	static constexpr u32 SHADER_VERSION = 1;
-
 	ComPtr<ID3D12RootSignature> m_tfx_root_signature;
 	ComPtr<ID3D12RootSignature> m_utility_root_signature;
 
diff --git a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
index 2415a4641b..faa8da6466 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
+++ b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.cpp
@@ -22,6 +22,7 @@
 #include "GS/GSUtil.h"
 #include "Host.h"
 #include "HostDisplay.h"
+#include "ShaderCacheVersion.h"
 #include <cinttypes>
 #include <fstream>
 #include <sstream>
@@ -206,7 +207,7 @@ bool GSDeviceOGL::Create()
 
 	if (!theApp.GetConfigB("disable_shader_cache"))
 	{
-		if (!m_shader_cache.Open(false, EmuFolders::Cache, SHADER_VERSION))
+		if (!m_shader_cache.Open(false, EmuFolders::Cache, SHADER_CACHE_VERSION))
 			Console.Warning("Shader cache failed to open.");
 	}
 	else
diff --git a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.h b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.h
index 4cbf7a5add..328fb187ff 100644
--- a/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.h
+++ b/pcsx2/GS/Renderers/OpenGL/GSDeviceOGL.h
@@ -211,9 +211,6 @@ public:
 	static int m_shader_reg;
 
 private:
-	// Increment this constant whenever shaders change, to invalidate user's program binary cache.
-	static constexpr u32 SHADER_VERSION = 3;
-
 	static FILE* m_debug_gl_file;
 
 	bool m_disable_hw_gl_draw;
diff --git a/pcsx2/ShaderCacheVersion.h b/pcsx2/ShaderCacheVersion.h
new file mode 100644
index 0000000000..1e930fa067
--- /dev/null
+++ b/pcsx2/ShaderCacheVersion.h
@@ -0,0 +1,18 @@
+/*  PCSX2 - PS2 Emulator for PCs
+ *  Copyright (C) 2002-2022  PCSX2 Dev Team
+ *
+ *  PCSX2 is free software: you can redistribute it and/or modify it under the terms
+ *  of the GNU Lesser General Public License as published by the Free Software Found-
+ *  ation, either version 3 of the License, or (at your option) any later version.
+ *
+ *  PCSX2 is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY;
+ *  without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR
+ *  PURPOSE.  See the GNU General Public License for more details.
+ *
+ *  You should have received a copy of the GNU General Public License along with PCSX2.
+ *  If not, see <http://www.gnu.org/licenses/>.
+ */
+
+/// Version number for GS and other shaders. Increment whenever any of the contents of the
+/// shaders change, to invalidate the cache.
+static constexpr u32 SHADER_CACHE_VERSION = 10;
diff --git a/pcsx2/pcsx2.vcxproj b/pcsx2/pcsx2.vcxproj
index ec6114d43f..468b6d4b39 100644
--- a/pcsx2/pcsx2.vcxproj
+++ b/pcsx2/pcsx2.vcxproj
@@ -869,6 +869,7 @@
     <ClInclude Include="PAD\Windows\WndProcEater.h" />
     <ClInclude Include="PAD\Windows\XInputEnum.h" />
     <ClInclude Include="PerformanceMetrics.h" />
+    <ClInclude Include="ShaderCacheVersion.h" />
     <ClInclude Include="SPU2\Config.h" />
     <ClInclude Include="SPU2\Global.h" />
     <ClInclude Include="SPU2\interpolate_table.h" />
diff --git a/pcsx2/pcsx2.vcxproj.filters b/pcsx2/pcsx2.vcxproj.filters
index 4328d14c04..4fe0482703 100644
--- a/pcsx2/pcsx2.vcxproj.filters
+++ b/pcsx2/pcsx2.vcxproj.filters
@@ -2996,6 +2996,9 @@
     <ClInclude Include="Frontend\ImGuiOverlays.h">
       <Filter>Host</Filter>
     </ClInclude>
+    <ClInclude Include="ShaderCacheVersion.h">
+      <Filter>System\Include</Filter>
+    </ClInclude>
   </ItemGroup>
   <ItemGroup>
     <ResourceCompile Include="windows\wxResources.rc">
@@ -3158,4 +3161,4 @@
       <Filter>AppHost\Resources</Filter>
     </Manifest>
   </ItemGroup>
-</Project>
\ No newline at end of file
+</Project>
diff --git a/pcsx2/pcsx2core.vcxproj b/pcsx2/pcsx2core.vcxproj
index 32bc4f8e89..2ef4c94201 100644
--- a/pcsx2/pcsx2core.vcxproj
+++ b/pcsx2/pcsx2core.vcxproj
@@ -566,6 +566,7 @@
     <ClInclude Include="Recording\InputRecordingFile.h" />
     <ClInclude Include="Recording\PadData.h" />
     <ClInclude Include="Recording\Utilities\InputRecordingLogger.h" />
+    <ClInclude Include="ShaderCacheVersion.h" />
     <ClInclude Include="SPU2\Config.h" />
     <ClInclude Include="SPU2\Global.h" />
     <ClInclude Include="SPU2\Host\Config.h" />