diff --git a/bin/resources/GameIndex.yaml b/bin/resources/GameIndex.yaml
index 10cfb0c1d1..e2da4744f9 100644
--- a/bin/resources/GameIndex.yaml
+++ b/bin/resources/GameIndex.yaml
@@ -24392,6 +24392,8 @@ SLKA-15032:
 SLKA-15033:
   name: "Princess Maker 2"
   region: "NTSC-K"
+  gsHWFixes:
+    partialTargetInvalidation: 1 # Fixes full screen C32->C16 frame invalidation.
 SLKA-15043:
   name: "Super Puzzle Bobble Collection Vol 1"
   region: "NTSC-K"
@@ -28605,6 +28607,8 @@ SLPM-62700:
 SLPM-62701:
   name: "Princess Maker 2 [Best Hit Selection]"
   region: "NTSC-J"
+  gsHWFixes:
+    partialTargetInvalidation: 1 # Fixes full screen C32->C16 frame invalidation.
 SLPM-62702:
   name: "Momotaro Densetsu 15"
   region: "NTSC-J"
@@ -37943,6 +37947,8 @@ SLPS-20392:
 SLPS-20393:
   name: "Princess Maker 2"
   region: "NTSC-J"
+  gsHWFixes:
+    partialTargetInvalidation: 1 # Fixes full screen C32->C16 frame invalidation.
 SLPS-20394:
   name: "Suki na Mono wa Sukida Rashouganai + White Flower + Sukisyo!"
   region: "NTSC-J"