diff --git a/pcsx2/gui/App.h b/pcsx2/gui/App.h
index 343105ea52..6b4ce59f92 100644
--- a/pcsx2/gui/App.h
+++ b/pcsx2/gui/App.h
@@ -737,3 +737,5 @@ extern void UI_DisableSysShutdown();
 	pxAssertMsg( !wxGetApp().SysExecutorThread.IsSelf(), "Thread affinity violation: Call is *not* allowed from SysExecutor thread." )
 
 extern ExecutorThread& GetSysExecutorThread();
+
+extern bool g_ConfigPanelChanged; //Indicates that the main config panel is open and holds unapplied changes.
\ No newline at end of file
diff --git a/pcsx2/gui/AppAccelerators.h b/pcsx2/gui/AppAccelerators.h
index f786d7eb66..479fa2122e 100644
--- a/pcsx2/gui/AppAccelerators.h
+++ b/pcsx2/gui/AppAccelerators.h
@@ -87,6 +87,8 @@ struct GlobalCommandDescriptor
 	const wxChar*	Fullname;			// Name displayed in pulldown menus
 	const wxChar*	Tooltip;			// text displayed in toolbar tooltips and menu status bars.
 
+	bool			AlsoApplyToGui;		// Indicates that the GUI should be updated if possible.
+
 	int				ToolbarIconId;		// not implemented yet, leave 0 for now.
 };
 
diff --git a/pcsx2/gui/Dialogs/BaseConfigurationDialog.cpp b/pcsx2/gui/Dialogs/BaseConfigurationDialog.cpp
index 36dce1e078..69bb9b8509 100644
--- a/pcsx2/gui/Dialogs/BaseConfigurationDialog.cpp
+++ b/pcsx2/gui/Dialogs/BaseConfigurationDialog.cpp
@@ -187,6 +187,7 @@ void Dialogs::BaseConfigurationDialog::AddOkCancel( wxSizer* sizer )
 {
 	_parent::AddOkCancel( sizer, true );
 	if( wxWindow* apply = FindWindow( wxID_APPLY ) ) apply->Disable();
+	SomethingChanged_StateModified_IsChanged();
 
 	wxBitmapButton& screenshotButton( *new wxBitmapButton( this, wxID_SAVE, EmbeddedImage<res_ButtonIcon_Camera>().Get() ) );
 	screenshotButton.SetToolTip( _("Saves a snapshot of this settings panel to a PNG file.") );
@@ -217,6 +218,7 @@ void Dialogs::BaseConfigurationDialog::OnSetSettingsPage( wxCommandEvent& evt )
 void Dialogs::BaseConfigurationDialog::SomethingChanged()
 {
 	if( wxWindow* apply = FindWindow( wxID_APPLY ) ) apply->Enable();
+	SomethingChanged_StateModified_IsChanged();
 }
 
 void Dialogs::BaseConfigurationDialog::OnSomethingChanged( wxCommandEvent& evt )
@@ -250,6 +252,7 @@ void Dialogs::BaseConfigurationDialog::OnOk_Click( wxCommandEvent& evt )
 	if( m_ApplyState.ApplyAll() )
 	{
 		if( wxWindow* apply = FindWindow( wxID_APPLY ) ) apply->Disable();
+		SomethingChanged_StateModified_IsChanged();
 		if( m_listbook ) GetConfSettingsTabName() = m_labels[m_listbook->GetSelection()];
 		AppSaveSettings();
 		disabler.DetachAll();
@@ -272,6 +275,8 @@ void Dialogs::BaseConfigurationDialog::OnApply_Click( wxCommandEvent& evt )
 
 	if( m_listbook ) GetConfSettingsTabName() = m_labels[m_listbook->GetSelection()];
 	AppSaveSettings();
+	
+	SomethingChanged_StateModified_IsChanged();
 }
 
 //avih: FIXME: ? for some reason, this OnCancel_Click is called twice when clicking cancel or closing the dialog (Jake's code?).
diff --git a/pcsx2/gui/Dialogs/ConfigurationDialog.h b/pcsx2/gui/Dialogs/ConfigurationDialog.h
index 48be152eba..60e7c947f3 100644
--- a/pcsx2/gui/Dialogs/ConfigurationDialog.h
+++ b/pcsx2/gui/Dialogs/ConfigurationDialog.h
@@ -20,6 +20,7 @@
 
 #include "AppCommon.h"
 #include "ApplyState.h"
+#include "App.h"
 
 namespace Panels
 {
@@ -62,6 +63,11 @@ namespace Dialogs
 		void AddPage( const wxChar* label, int iconid );
 
 		void AllowApplyActivation( bool allow=true );
+		virtual bool SomethingChanged_StateModified_IsChanged(){ //returns the state of the apply button.
+			if( wxWindow* apply = FindWindow( wxID_APPLY ) )
+				return apply->IsEnabled();
+			return false;
+		}
 
 	protected:
 		void OnSettingsApplied( wxCommandEvent& evt );
@@ -94,6 +100,12 @@ namespace Dialogs
    		void Apply();
 		void Cancel();
 
+		//Stores the state of the apply button in a global var.
+		//This var will be used by KB shortcuts commands to decide if the gui should be modified (only when no intermediate changes)
+		virtual bool SomethingChanged_StateModified_IsChanged(){
+			return g_ConfigPanelChanged = BaseConfigurationDialog::SomethingChanged_StateModified_IsChanged();
+		}
+
 	protected:
 		virtual wxString& GetConfSettingsTabName() const { return g_Conf->SysSettingsTabName; }
 
diff --git a/pcsx2/gui/Dialogs/SysConfigDialog.cpp b/pcsx2/gui/Dialogs/SysConfigDialog.cpp
index 070ae812e4..8e71c9f48c 100644
--- a/pcsx2/gui/Dialogs/SysConfigDialog.cpp
+++ b/pcsx2/gui/Dialogs/SysConfigDialog.cpp
@@ -307,3 +307,5 @@ void AppearanceThemesPanel::AppStatusEvent_OnSettingsApplied()
 {
 
 }
+
+bool g_ConfigPanelChanged = false;
\ No newline at end of file
diff --git a/pcsx2/gui/FrameForGS.cpp b/pcsx2/gui/FrameForGS.cpp
index 45707c8610..21dcf8b755 100644
--- a/pcsx2/gui/FrameForGS.cpp
+++ b/pcsx2/gui/FrameForGS.cpp
@@ -222,6 +222,9 @@ void GSPanel::DirectKeyCommand( const KeyAcceleratorCode& kac )
 
 	DbgCon.WriteLn( "(gsFrame) Invoking command: %s", cmd->Id );
 	cmd->Invoke();
+	
+	if( cmd->AlsoApplyToGui && !g_ConfigPanelChanged)
+		AppApplySettings();
 }
 
 void GSPanel::DirectKeyCommand( wxKeyEvent& evt )
diff --git a/pcsx2/gui/GlobalCommands.cpp b/pcsx2/gui/GlobalCommands.cpp
index 2472a62ed6..f99e20d92c 100644
--- a/pcsx2/gui/GlobalCommands.cpp
+++ b/pcsx2/gui/GlobalCommands.cpp
@@ -16,6 +16,8 @@
 #include "PrecompiledHeader.h"
 #include "MainFrame.h"
 #include "GSFrame.h"
+#include "ApplyState.h"
+
 
 #include "AppAccelerators.h"
 #include "AppSaveStates.h"
@@ -161,6 +163,16 @@ namespace Implementations
 		pauser.AllowResume();
 	}
 
+	void UpdateImagePosition()
+	{
+		//AppApplySettings() would have been nicer, since it also immidiately affects the GUI (if open).
+		//However, the events sequence it generates also "depresses" Shift/CTRL/etc, so consecutive zoom with CTRL down breaks.
+		//Since zoom only affects the window viewport anyway, we can live with directly calling it.
+		if (GSFrame* gsFrame = wxGetApp().GetGsFramePtr())
+			if (GSPanel* woot = gsFrame->GetViewport())
+				woot->DoResize();
+	}
+
 	void GSwindow_CycleAspectRatio()
 	{
 		AspectRatioType& art = g_Conf->GSWindow.AspectRatio;
@@ -173,17 +185,7 @@ namespace Implementations
 		}
 
 		Console.WriteLn(L"(GSwindow) Aspect ratio: %s.", arts.c_str());
-		AppApplySettings();
-	}
-
-	void UpdateImagePosition()
-	{
-		//AppApplySettings() would have been nicer, since it also immidiately affects the GUI (if open).
-		//However, the events sequence it generates also "depresses" Shift/CTRL/etc, so consecutive zoom with CTRL down breaks.
-		//Since zoom only affects the window viewport anyway, we can live with directly calling it.
-		if (GSFrame* gsFrame = wxGetApp().GetGsFramePtr())
-			if (GSPanel* woot = gsFrame->GetViewport())
-				woot->DoResize();
+		UpdateImagePosition();
 	}
 
 	void SetOffset(float x, float y)
@@ -432,12 +434,14 @@ static const GlobalCommandDescriptor CommandDeclarations[] =
 		Implementations::Framelimiter_MasterToggle,
 		NULL,
 		NULL,
+		true,
 	},
 
 	{	"GSwindow_CycleAspectRatio",
 		Implementations::GSwindow_CycleAspectRatio,
 		NULL,
 		NULL,
+		true,
 	},
 
 	{	"GSwindow_ZoomIn",