diff --git a/pcsx2/GS/GSVector4.h b/pcsx2/GS/GSVector4.h
index 0a256258f1..13f4073cbb 100644
--- a/pcsx2/GS/GSVector4.h
+++ b/pcsx2/GS/GSVector4.h
@@ -205,6 +205,17 @@ public:
 		return m;
 	}
 
+	/// Makes Clang think that the whole vector is needed, preventing it from changing shuffles around because it thinks we don't need the whole vector
+	/// Useful for e.g. preventing clang from optimizing shuffles that remove possibly-denormal garbage data from vectors before computing with them
+	__forceinline GSVector4 noopt()
+	{
+		// Note: Clang is currently the only compiler that attempts to optimize vector intrinsics, if that changes in the future the implementation should be updated
+#ifdef __clang__
+		__asm__("":"+x"(m)::);
+#endif
+		return *this;
+	}
+
 	__forceinline uint32 rgba32() const
 	{
 		return GSVector4i(*this).rgba32();
diff --git a/pcsx2/GS/Renderers/Common/GSVertexTrace.cpp b/pcsx2/GS/Renderers/Common/GSVertexTrace.cpp
index 306dffa316..a3d59c4ecb 100644
--- a/pcsx2/GS/Renderers/Common/GSVertexTrace.cpp
+++ b/pcsx2/GS/Renderers/Common/GSVertexTrace.cpp
@@ -202,9 +202,9 @@ void GSVertexTrace::FindMinMax(const void* vertex, const uint32* index, int coun
 					GSVector4 q = stq.wwww();
 
 					if (accurate_stq)
-						stq = (stq.xyww() / q).xyww(q);
+						stq = (stq.xyww() / q).noopt().xyww(q);
 					else
-						stq = (stq.xyww() * q.rcpnr()).xyww(q);
+						stq = (stq.xyww() * q.rcpnr()).noopt().xyww(q);
 
 					tmin = tmin.min(stq);
 					tmax = tmax.max(stq);
@@ -256,19 +256,21 @@ void GSVertexTrace::FindMinMax(const void* vertex, const uint32* index, int coun
 					GSVector4 stq0 = GSVector4::cast(c0);
 					GSVector4 stq1 = GSVector4::cast(c1);
 
+					GSVector4 q = stq0.wwww(stq1);
+
 					if (accurate_stq)
 					{
-						GSVector4 q = stq0.wwww(stq1);
+						GSVector4 st = stq0.xyxy(stq1) / q;
 
-						stq0 = (stq0.xyww() / q.xxxx()).xyww(stq0);
-						stq1 = (stq1.xyww() / q.zzzz()).xyww(stq1);
+						stq0 = st.xyww(stq1);
+						stq1 = st.zwww(stq1);
 					}
 					else
 					{
-						GSVector4 q = stq0.wwww(stq1).rcpnr();
+						GSVector4 st = stq0.xyxy(stq1) * q.rcpnr();
 
-						stq0 = (stq0.xyww() * q.xxxx()).xyww(stq0);
-						stq1 = (stq1.xyww() * q.zzzz()).xyww(stq1);
+						stq0 = st.xyww(stq0);
+						stq1 = st.zwww(stq1);
 					}
 
 					tmin = tmin.min(stq0.min(stq1));
@@ -331,19 +333,20 @@ void GSVertexTrace::FindMinMax(const void* vertex, const uint32* index, int coun
 
 					if (accurate_stq)
 					{
-						GSVector4 q = stq0.wwww(stq1).xzww(stq2);
+						GSVector4 st01 = stq0.xyxy(stq1) / stq0.wwww(stq1);
 
-						stq0 = (stq0.xyww() / q.xxxx()).xyww(stq0);
-						stq1 = (stq1.xyww() / q.yyyy()).xyww(stq1);
-						stq2 = (stq2.xyww() / q.zzzz()).xyww(stq2);
+						stq0 = st01.xyww(stq0);
+						stq1 = st01.zwww(stq1);
+						stq2 = (stq2.xyww() / stq2.wwww()).noopt().xyww(stq2);
 					}
 					else
 					{
 						GSVector4 q = stq0.wwww(stq1).xzww(stq2).rcpnr();
+						GSVector4 st01 = stq0.xyxy(stq1) * q.xxyy();
 
-						stq0 = (stq0.xyww() * q.xxxx()).xyww(stq0);
-						stq1 = (stq1.xyww() * q.yyyy()).xyww(stq1);
-						stq2 = (stq2.xyww() * q.zzzz()).xyww(stq2);
+						stq0 = st01.xyww(stq0);
+						stq1 = st01.zwww(stq1);
+						stq2 = (stq2.xyww() * q.zzzz()).noopt().xyww(stq2);
 					}
 
 					tmin = tmin.min(stq2).min(stq0.min(stq1));
@@ -410,17 +413,17 @@ void GSVertexTrace::FindMinMax(const void* vertex, const uint32* index, int coun
 
 					if (accurate_stq)
 					{
-						GSVector4 q = stq1.wwww();
+						GSVector4 st = stq0.xyxy(stq1) / stq1.wwww();
 
-						stq0 = (stq0.xyww() / q).xyww(stq1);
-						stq1 = (stq1.xyww() / q).xyww(stq1);
+						stq0 = st.xyww(stq1);
+						stq1 = st.zwww(stq1);
 					}
 					else
 					{
-						GSVector4 q = stq1.wwww().rcpnr();
+						GSVector4 st = stq0.xyxy(stq1) * stq1.wwww().rcpnr();
 
-						stq0 = (stq0.xyww() * q).xyww(stq1);
-						stq1 = (stq1.xyww() * q).xyww(stq1);
+						stq0 = st.xyww(stq1);
+						stq1 = st.zwww(stq1);
 					}
 
 					tmin = tmin.min(stq0.min(stq1));