diff --git a/pcsx2/GS/GSBlock.h b/pcsx2/GS/GSBlock.h
index 3e3360c1ad..34e030b253 100644
--- a/pcsx2/GS/GSBlock.h
+++ b/pcsx2/GS/GSBlock.h
@@ -502,7 +502,7 @@ public:
 		GSVector8i::store<true>(&dst[dstpitch * 0], v0);
 		GSVector8i::store<true>(&dst[dstpitch * 1], v1);
 
-#elif _M_SSE >= 0x301
+#else
 
 		const GSVector4i* s = (const GSVector4i*)src;
 
@@ -1340,7 +1340,7 @@ public:
 		((GSVector8i*)dst)[6] = ((GSVector8i*)dst)[6].blend8(v2, mask);
 		((GSVector8i*)dst)[7] = ((GSVector8i*)dst)[7].blend8(v3, mask);
 
-#elif _M_SSE >= 0x301
+#else
 
 		GSVector4i v0, v1, v2, v3, v4;
 		GSVector4i mask = GSVector4i::xff000000();
@@ -1423,7 +1423,7 @@ public:
 		((GSVector8i*)dst)[6] = ((GSVector8i*)dst)[6].blend(v2, mask);
 		((GSVector8i*)dst)[7] = ((GSVector8i*)dst)[7].blend(v3, mask);
 
-#elif _M_SSE >= 0x301
+#else
 
 		GSVector4i v0, v1, v2, v3, v4, v5;
 		GSVector4i mask = GSVector4i(0x0f000000);
@@ -1510,7 +1510,7 @@ public:
 		((GSVector8i*)dst)[6] = ((GSVector8i*)dst)[6].blend(v2, mask);
 		((GSVector8i*)dst)[7] = ((GSVector8i*)dst)[7].blend(v3, mask);
 
-#elif _M_SSE >= 0x301
+#else
 
 		GSVector4i v0, v1, v2, v3, v4, v5;
 		GSVector4i mask = GSVector4i::xf0000000();
diff --git a/pcsx2/GS/GSCapture.cpp b/pcsx2/GS/GSCapture.cpp
index 61dbeab118..278c5041c7 100644
--- a/pcsx2/GS/GSCapture.cpp
+++ b/pcsx2/GS/GSCapture.cpp
@@ -321,8 +321,6 @@ public:
 			{
 				if (rgba)
 				{
-#if _M_SSE >= 0x301
-
 					GSVector4i* s = (GSVector4i*)src;
 					GSVector4i* d = (GSVector4i*)dst;
 
@@ -332,18 +330,6 @@ public:
 					{
 						d[i] = s[i].shuffle8(mask);
 					}
-
-#else
-
-					GSVector4i* s = (GSVector4i*)src;
-					GSVector4i* d = (GSVector4i*)dst;
-
-					for (int i = 0, w4 = w >> 2; i < w4; i++)
-					{
-						d[i] = ((s[i] & 0x00ff0000) >> 16) | ((s[i] & 0x000000ff) << 16) | (s[i] & 0x0000ff00);
-					}
-
-#endif
 				}
 				else
 				{
diff --git a/pcsx2/GS/GSState.cpp b/pcsx2/GS/GSState.cpp
index 2b15b8c98c..c6c3c6832d 100644
--- a/pcsx2/GS/GSState.cpp
+++ b/pcsx2/GS/GSState.cpp
@@ -589,21 +589,11 @@ void GSState::GIFPackedRegHandlerNull(const GIFPackedReg* RESTRICT r)
 
 void GSState::GIFPackedRegHandlerRGBA(const GIFPackedReg* RESTRICT r)
 {
-#if _M_SSE >= 0x301
-
 	GSVector4i mask = GSVector4i::load(0x0c080400);
 	GSVector4i v = GSVector4i::load<false>(r).shuffle8(mask);
 
 	m_v.RGBAQ.u32[0] = (uint32)GSVector4i::store(v);
 
-#else
-
-	GSVector4i v = GSVector4i::load<false>(r) & GSVector4i::x000000ff();
-
-	m_v.RGBAQ.u32[0] = v.rgba32();
-
-#endif
-
 	m_v.RGBAQ.Q = m_q;
 }
 
diff --git a/pcsx2/GS/GSVector4i.h b/pcsx2/GS/GSVector4i.h
index ca2efdd021..1c70c52453 100644
--- a/pcsx2/GS/GSVector4i.h
+++ b/pcsx2/GS/GSVector4i.h
@@ -912,16 +912,11 @@ public:
 	__forceinline GSVector4i modulate16(const GSVector4i& f) const
 	{
 		// a * f << shift
-
-#if _M_SSE >= 0x301
-
 		if (shift == 0)
 		{
 			return mul16hrs(f);
 		}
 
-#endif
-
 		return sll16(shift + 1).mul16hs(f);
 	}