diff --git a/pcsx2/x86/microVU_Macro.inl b/pcsx2/x86/microVU_Macro.inl
index a2afd0221a..20a7a53f94 100644
--- a/pcsx2/x86/microVU_Macro.inl
+++ b/pcsx2/x86/microVU_Macro.inl
@@ -64,6 +64,16 @@ void endMacroOp(int mode) {
 		xMOV(ptr32[&vu0Regs.VI[REG_STATUS_FLAG].UL], gprF0);
 	}
 	microVU0.regAlloc->flushAll();
+
+	if (mode & 0x10) { // Update VU0 Status/Mac instances after flush to avoid corrupting anything
+		xMOVDZX(xmmT1, ptr32[&vu0Regs.VI[REG_STATUS_FLAG].UL]);
+		xSHUF.PS(xmmT1, xmmT1, 0);
+		xMOVAPS(ptr128[&microVU0.regs().micro_statusflags], xmmT1);
+
+		xMOVDZX(xmmT1, ptr32[&vu0Regs.VI[REG_MAC_FLAG].UL]);
+		xSHUF.PS(xmmT1, xmmT1, 0);
+		xMOVAPS(ptr128[&microVU0.regs().micro_macflags], xmmT1);
+	}
 	microVU0.cop2 = 0;
 }