diff --git a/pcsx2/PCSX2Base.h b/pcsx2/PCSX2Base.h
index 96aa82ef9b..59a05bd67d 100644
--- a/pcsx2/PCSX2Base.h
+++ b/pcsx2/PCSX2Base.h
@@ -36,6 +36,14 @@
 	#error PCSX2 requires compiling for at least SSE 4.1
 #endif
 
+// Require 32 bit alignment for vectors for AVX2.
+#if _M_SSE >= 0x501
+	#define SSE_ALIGN_N 32
+#else
+	#define SSE_ALIGN_N 16
+#endif
+#define SSE_ALIGN alignas(SSE_ALIGN_N)
+
 // Starting with AVX, processors have fast unaligned loads
 // Reduce code duplication by not compiling multiple versions
 #if _M_SSE >= 0x500
diff --git a/pcsx2/x86/microVU.h b/pcsx2/x86/microVU.h
index a3ce717493..2ce22cd1fd 100644
--- a/pcsx2/x86/microVU.h
+++ b/pcsx2/x86/microVU.h
@@ -92,7 +92,7 @@ public:
 
 			microBlockLink*& blockList = fullCmp ? fBlockList : qBlockList;
 			microBlockLink*& blockEnd  = fullCmp ? fBlockEnd  : qBlockEnd;
-			microBlockLink*  newBlock  = (microBlockLink*)_aligned_malloc(sizeof(microBlockLink), 16);
+			microBlockLink*  newBlock  = (microBlockLink*)_aligned_malloc(sizeof(microBlockLink), SSE_ALIGN_N);
 			newBlock->block.jumpCache  = NULL;
 			newBlock->next = NULL;
 
diff --git a/pcsx2/x86/microVU_Misc.h b/pcsx2/x86/microVU_Misc.h
index 38daa9fd3b..41d34a203d 100644
--- a/pcsx2/x86/microVU_Misc.h
+++ b/pcsx2/x86/microVU_Misc.h
@@ -198,7 +198,11 @@ typedef Fntype_mVUrecInst* Fnptr_mVUrecInst;
 //------------------------------------------------------------------
 alignas(__pagesize) extern u8 mVUsearchXMM[__pagesize];
 typedef u32 (*mVUCall)(void*, void*);
+#if _M_SSE >= 0x501
+#define mVUquickSearch(dest, src, size) ((((mVUCall)((void*)mVUsearchXMM))(dest, src)) == 0xff)
+#else
 #define mVUquickSearch(dest, src, size) ((((mVUCall)((void*)mVUsearchXMM))(dest, src)) == 0xf)
+#endif
 #define mVUemitSearch() \
 	{ \
 		mVUcustomSearch(); \
diff --git a/pcsx2/x86/microVU_Misc.inl b/pcsx2/x86/microVU_Misc.inl
index c2cf097eb7..f5826780f2 100644
--- a/pcsx2/x86/microVU_Misc.inl
+++ b/pcsx2/x86/microVU_Misc.inl
@@ -537,6 +537,7 @@ void mVUcustomSearch()
 	memset(mVUsearchXMM, 0xcc, __pagesize);
 	xSetPtr(mVUsearchXMM);
 
+#if _M_SSE < 0x501
 	xMOVAPS  (xmm0, ptr32[arg1reg]);
 	xPCMP.EQD(xmm0, ptr32[arg2reg]);
 	xMOVAPS  (xmm1, ptr32[arg1reg + 0x10]);
@@ -576,7 +577,34 @@ void mVUcustomSearch()
 	xPAND (xmm0, xmm4);
 	xMOVMSKPS(eax, xmm0);
 
+#else
+	// We have to use unaligned loads here, because the blocks are only 16 byte aligned.
+	xVMOVUPS(ymm0, ptr[arg1reg]);
+	xVPCMP.EQD(ymm0, ymm0, ptr[arg2reg]);
+	xVMOVMSKPS(eax, ymm0);
+	xCMP(eax, 0xff);
+	xForwardJB8 exitPoint;
+
+	xVMOVUPS(ymm0, ptr[arg1reg + 0x20]);
+	xVPCMP.EQD(ymm0, ymm0, ptr[arg2reg + 0x20]);
+
+	xVMOVUPS(ymm1, ptr[arg1reg + 0x40]);
+	xVPCMP.EQD(ymm1, ymm1, ptr[arg2reg + 0x40]);
+
+	xVMOVUPS(ymm2, ptr[arg1reg + 0x60]);
+	xVPCMP.EQD(ymm2, ymm2, ptr[arg2reg + 0x60]);
+	xVPAND(ymm0, ymm0, ymm1);
+
+	xVMOVUPS(ymm2, ptr[arg1reg + 0x80]);
+	xVPCMP.EQD(ymm2, ymm2, ptr[arg2reg + 0x80]);
+	xVPAND(ymm0, ymm0, ymm2);
+
+	xVMOVMSKPS(eax, ymm0);
+	xVZEROUPPER();
+#endif
+
 	exitPoint.SetTarget();
+
 	xRET();
 	HostSys::MemProtectStatic(mVUsearchXMM, PageAccess_ExecOnly());
 }