diff --git a/pcsx2/GS/Renderers/HW/GSTextureCache.cpp b/pcsx2/GS/Renderers/HW/GSTextureCache.cpp
index a482eb7e6d..10c0b68113 100644
--- a/pcsx2/GS/Renderers/HW/GSTextureCache.cpp
+++ b/pcsx2/GS/Renderers/HW/GSTextureCache.cpp
@@ -299,7 +299,7 @@ GSTextureCache::Source* GSTextureCache::LookupSource(const GIFRegTEX0& TEX0, con
 		// to offset the actual texture data to elsewhere. So, we'll just force any cases like this down
 		// the region texture path.
 		const u32 rw = ((CLAMP.MINU | CLAMP.MAXU) - CLAMP.MAXU) + 1;
-		if (rw < (1u << TEX0.TW) || CLAMP.MAXU != 0)
+		if (rw < (1u << TEX0.TW) || (CLAMP.MAXU != 0 && (rw <= (1u << TEX0.TW))))
 		{
 			region.SetX(CLAMP.MAXU, (CLAMP.MINU | CLAMP.MAXU) + 1);
 			GL_CACHE("TC: Region repeat optimization: %d width -> %d", 1 << TEX0.TW, region.GetWidth());
@@ -317,7 +317,7 @@ GSTextureCache::Source* GSTextureCache::LookupSource(const GIFRegTEX0& TEX0, con
 	else if (CLAMP.WMT == CLAMP_REGION_REPEAT && CLAMP.MINV != 0)
 	{
 		const u32 rh = ((CLAMP.MINV | CLAMP.MAXV) - CLAMP.MAXV) + 1;
-		if (rh < (1u << TEX0.TH) || CLAMP.MAXV != 0)
+		if (rh < (1u << TEX0.TH) || (CLAMP.MAXV != 0 && (rh <= (1u << TEX0.TH))))
 		{
 			region.SetY(CLAMP.MAXV, (CLAMP.MINV | CLAMP.MAXV) + 1);
 			GL_CACHE("TC: Region repeat optimization: %d height -> %d", 1 << TEX0.TW, region.GetHeight());