diff --git a/pcsx2-qt/MainWindow.cpp b/pcsx2-qt/MainWindow.cpp
index f451a574c6..2441db5468 100644
--- a/pcsx2-qt/MainWindow.cpp
+++ b/pcsx2-qt/MainWindow.cpp
@@ -107,6 +107,7 @@ MainWindow::MainWindow()
 #if !defined(_WIN32) && !defined(__APPLE__)
 	s_use_central_widget = DisplayContainer::isRunningOnWayland();
 #endif
+	createCheckMousePositionTimer();
 }
 
 MainWindow::~MainWindow()
@@ -1071,6 +1072,21 @@ bool MainWindow::shouldHideMainWindow() const
 		   QtHost::InNoGUIMode();
 }
 
+bool MainWindow::shouldMouseGrab() const
+{
+	if (!s_vm_valid || s_vm_paused)
+		return false;
+
+	if (!Host::GetBoolSettingValue("EmuCore", "EnableMouseGrab", false))
+		return false;
+
+	bool windowsHidden = (!m_debugger_window || m_debugger_window->isHidden()) &&
+						 (!m_controller_settings_window || m_controller_settings_window->isHidden()) &&
+						 (!m_settings_window || m_settings_window->isHidden());
+
+	return windowsHidden && (isActiveWindow() || isRenderingFullscreen());
+}
+
 bool MainWindow::shouldAbortForMemcardBusy(const VMLock& lock)
 {
 	if (MemcardBusy::IsBusy() && !GSDumpReplayer::IsReplayingDump())
@@ -2541,6 +2557,35 @@ QWidget* MainWindow::getDisplayContainer() const
 	return (m_display_container ? static_cast<QWidget*>(m_display_container) : static_cast<QWidget*>(m_display_widget));
 }
 
+void MainWindow::createCheckMousePositionTimer()
+{
+	m_mouse_check_timer = new QTimer(this);
+	connect(m_mouse_check_timer, &QTimer::timeout, this, &MainWindow::checkMousePosition);
+	m_mouse_check_timer->start(16);
+}
+
+void MainWindow::checkMousePosition()
+{
+	if (!shouldMouseGrab())
+		return;
+
+	QPoint globalCursorPos = QCursor::pos();
+	const QRect& windowBounds = isRenderingFullscreen() ? screen()->geometry() : geometry();
+
+	if (windowBounds.contains(globalCursorPos))
+		return;
+
+	QCursor::setPos(
+		std::clamp(globalCursorPos.x(), windowBounds.left(), windowBounds.right()),
+		std::clamp(globalCursorPos.y(), windowBounds.top(), windowBounds.bottom()));
+}
+
+void MainWindow::mouseMoveEvent(QMouseEvent* event)
+{
+	QWidget::mouseMoveEvent(event);
+}
+
+
 void MainWindow::saveDisplayWindowGeometryToConfig()
 {
 	QWidget* container = getDisplayContainer();
diff --git a/pcsx2-qt/MainWindow.h b/pcsx2-qt/MainWindow.h
index 0509b58be6..8f73bb24b8 100644
--- a/pcsx2-qt/MainWindow.h
+++ b/pcsx2-qt/MainWindow.h
@@ -128,7 +128,7 @@ private Q_SLOTS:
 	void mouseModeRequested(bool relative_mode, bool hide_cursor);
 	void releaseRenderWindow();
 	void focusDisplayWidget();
-
+	void createCheckMousePositionTimer();
 	void onGameListRefreshComplete();
 	void onGameListRefreshProgress(const QString& status, int current, int total);
 	void onGameListSelectionChanged();
@@ -182,13 +182,14 @@ private Q_SLOTS:
 	void onInputRecPlayActionTriggered();
 	void onInputRecStopActionTriggered();
 	void onInputRecOpenViewer();
-
 	void onVMStarting();
 	void onVMStarted();
 	void onVMPaused();
 	void onVMResumed();
 	void onVMStopped();
 
+	void checkMousePosition();
+
 	void onGameChanged(const QString& title, const QString& elf_override, const QString& disc_path,
 		const QString& serial, quint32 disc_crc, quint32 crc);
 
@@ -206,6 +207,7 @@ protected:
 	void dropEvent(QDropEvent* event) override;
 	void moveEvent(QMoveEvent* event) override;
 	void resizeEvent(QResizeEvent* event) override;
+	void mouseMoveEvent(QMouseEvent* event) override;
 
 #ifdef _WIN32
 	bool nativeEvent(const QByteArray& eventType, void* message, qintptr* result) override;
@@ -240,6 +242,7 @@ private:
 	bool isRenderingToMain() const;
 	bool shouldHideMouseCursor() const;
 	bool shouldHideMainWindow() const;
+	bool shouldMouseGrab() const;
 	void switchToGameListView();
 	void switchToEmulationView();
 
@@ -312,6 +315,8 @@ private:
 
 	QString m_last_fps_status;
 
+	QTimer* m_mouse_check_timer = nullptr;
+
 #ifdef _WIN32
 	void* m_device_notification_handle = nullptr;
 #endif
diff --git a/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp b/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
index 9d5e57e6fa..7e1b0ee966 100644
--- a/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
+++ b/pcsx2-qt/Settings/InterfaceSettingsWidget.cpp
@@ -80,6 +80,8 @@ InterfaceSettingsWidget::InterfaceSettingsWidget(SettingsWindow* dialog, QWidget
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.pauseOnControllerDisconnection, "UI", "PauseOnControllerDisconnection", false);
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.discordPresence, "EmuCore", "EnableDiscordPresence", false);
 
+	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.mouseGrab, "EmuCore", "EnableMouseGrab", false);
+
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.startFullscreen, "UI", "StartFullscreen", false);
 	SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.doubleClickTogglesFullscreen, "UI", "DoubleClickTogglesFullscreen",
 		true);
@@ -161,6 +163,9 @@ InterfaceSettingsWidget::InterfaceSettingsWidget(SettingsWindow* dialog, QWidget
 	dialog->registerWidgetHelp(
 		m_ui.discordPresence, tr("Enable Discord Presence"), tr("Unchecked"),
 		tr("Shows the game you are currently playing as part of your profile in Discord."));
+	dialog->registerWidgetHelp(
+		m_ui.mouseGrab, tr("Enable Mouse Grab"), tr("Unchecked"),
+		tr("Locks the mouse cursor to the windows when PCSX2 is in focus."));
 	dialog->registerWidgetHelp(
 		m_ui.doubleClickTogglesFullscreen, tr("Double-Click Toggles Fullscreen"), tr("Checked"),
 		tr("Allows switching in and out of fullscreen mode by double-clicking the game window."));
diff --git a/pcsx2-qt/Settings/InterfaceSettingsWidget.ui b/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
index f42b72f094..6fc709aa20 100644
--- a/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
+++ b/pcsx2-qt/Settings/InterfaceSettingsWidget.ui
@@ -50,6 +50,13 @@
         </property>
        </widget>
       </item>
+      <item row="3" column="0">
+       <widget class="QCheckBox" name="mouseGrab">
+        <property name="text">
+         <string>Enable Mouse Grab</string>
+        </property>
+       </widget>
+      </item>
       <item row="1" column="1">
        <widget class="QCheckBox" name="pauseOnStart">
         <property name="text">