diff --git a/CHANGES b/CHANGES
index ac1e26b5f..6ccbb6823 100644
--- a/CHANGES
+++ b/CHANGES
@@ -4,6 +4,7 @@ Features:
 Bugfixes:
  - GB Audio: Make audio unsigned with bias (fixes mgba.io/i/749)
  - Python: Fix importing .gb or .gba before .core
+ - GBA: Reset active region as needed when loading a ROM
 Misc:
  - GBA Timer: Use global cycles for timers
  - GBA: Extend oddly-sized ROMs to full address space (fixes mgba.io/i/722)
diff --git a/src/gba/gba.c b/src/gba/gba.c
index fb3680cc0..3baaea232 100644
--- a/src/gba/gba.c
+++ b/src/gba/gba.c
@@ -312,6 +312,10 @@ bool GBALoadNull(struct GBA* gba) {
 	gba->memory.romMask = SIZE_CART0 - 1;
 	gba->memory.mirroring = false;
 	gba->romCrc32 = 0;
+
+	if (gba->cpu) {
+		gba->cpu->memory.setActiveRegion(gba->cpu, gba->cpu->gprs[ARM_PC]);
+	}
 	return true;
 }
 
@@ -335,6 +339,9 @@ bool GBALoadMB(struct GBA* gba, struct VFile* vf) {
 	gba->memory.romSize = 0;
 	gba->memory.romMask = 0;
 	gba->romCrc32 = doCrc32(gba->memory.wram, gba->pristineRomSize);
+	if (gba->cpu && gba->memory.activeRegion == REGION_WORKING_RAM) {
+		gba->cpu->memory.setActiveRegion(gba->cpu, gba->cpu->gprs[ARM_PC]);
+	}
 	return true;
 }
 
@@ -379,6 +386,9 @@ bool GBALoadROM(struct GBA* gba, struct VFile* vf) {
 		gba->memory.romSize = SIZE_CART0;
 		gba->isPristine = false;
 	}
+	if (gba->cpu && gba->memory.activeRegion >= REGION_CART0) {
+		gba->cpu->memory.setActiveRegion(gba->cpu, gba->cpu->gprs[ARM_PC]);
+	}
 	// TODO: error check
 	return true;
 }