diff --git a/CHANGES b/CHANGES
index 8e371932a..a2bf6d97a 100644
--- a/CHANGES
+++ b/CHANGES
@@ -21,6 +21,7 @@ Other fixes:
  - Qt: Fix savestate preview sizes with different scales (fixes mgba.io/i/2560)
 Misc:
  - Core: Handle relative paths for saves, screenshots, etc consistently (fixes mgba.io/i/2826)
+ - GB: Prevent incompatible BIOSes from being used on differing models
  - GB Serialize: Add missing savestate support for MBC6 and NT (newer)
  - GBA: Improve detection of valid ELF ROMs
  - mGUI: Enable auto-softpatching (closes mgba.io/i/2899)
diff --git a/include/mgba/gb/interface.h b/include/mgba/gb/interface.h
index 0ec54559f..ecd99e2f9 100644
--- a/include/mgba/gb/interface.h
+++ b/include/mgba/gb/interface.h
@@ -71,6 +71,7 @@ struct VFile;
 
 bool GBIsROM(struct VFile* vf);
 bool GBIsBIOS(struct VFile* vf);
+bool GBIsCompatibleBIOS(struct VFile* vf, enum GBModel model);
 
 enum GBModel GBNameToModel(const char*);
 const char* GBModelToName(enum GBModel);
diff --git a/src/gb/gb.c b/src/gb/gb.c
index 4cbff7e4f..899d5cfc7 100644
--- a/src/gb/gb.c
+++ b/src/gb/gb.c
@@ -530,6 +530,23 @@ bool GBIsBIOS(struct VFile* vf) {
 	}
 }
 
+bool GBIsCompatibleBIOS(struct VFile* vf, enum GBModel model) {
+	switch (_GBBiosCRC32(vf)) {
+	case DMG_BIOS_CHECKSUM:
+	case DMG0_BIOS_CHECKSUM:
+	case MGB_BIOS_CHECKSUM:
+	case SGB_BIOS_CHECKSUM:
+	case SGB2_BIOS_CHECKSUM:
+		return model < GB_MODEL_CGB;
+	case CGB_BIOS_CHECKSUM:
+	case CGB0_BIOS_CHECKSUM:
+	case AGB_BIOS_CHECKSUM:
+		return model >= GB_MODEL_CGB;
+	default:
+		return false;
+	}
+}
+
 void GBReset(struct SM83Core* cpu) {
 	struct GB* gb = (struct GB*) cpu->master;
 	gb->memory.romBase = gb->memory.rom;
@@ -562,7 +579,7 @@ void GBReset(struct SM83Core* cpu) {
 	GBMemoryReset(gb);
 
 	if (gb->biosVf) {
-		if (!GBIsBIOS(gb->biosVf)) {
+		if (!GBIsCompatibleBIOS(gb->biosVf, gb->model)) {
 			gb->biosVf->close(gb->biosVf);
 			gb->biosVf = NULL;
 		} else {