diff --git a/CHANGES b/CHANGES
index 6d5757ee1..04bd6fc8e 100644
--- a/CHANGES
+++ b/CHANGES
@@ -5,6 +5,7 @@ Bugfixes:
  - GBA Thread: Allow halted games to exit cleanly
  - GBA BIOS: Fix HLE Lz77 and RL functions to properly account for width and invalid addresses
  - ARM7: Fix LDM writeback to a register already written
+ - GBA Memory: Don't call into GPIO write calls if GPIO devices are absent
 Misc:
  - Qt: Disable sync to video by default
 
diff --git a/src/gba/gba-memory.c b/src/gba/gba-memory.c
index 1d3fb9147..02b8c035a 100644
--- a/src/gba/gba-memory.c
+++ b/src/gba/gba-memory.c
@@ -581,7 +581,7 @@ void GBAStore16(struct ARMCore* cpu, uint32_t address, int16_t value, int* cycle
 		gba->video.renderer->writeOAM(gba->video.renderer, (address & (SIZE_OAM - 1)) >> 1);
 		break;
 	case REGION_CART0:
-		if (IS_GPIO_REGISTER(address & 0xFFFFFF)) {
+		if (memory->gpio.gpioDevices != GPIO_NONE && IS_GPIO_REGISTER(address & 0xFFFFFF)) {
 			uint32_t reg = address & 0xFFFFFF;
 			GBAGPIOWrite(&memory->gpio, reg, value);
 		} else {