diff --git a/src/duckstation-qt/debuggerwindow.cpp b/src/duckstation-qt/debuggerwindow.cpp
index 1f6115bb7..329ebdda3 100644
--- a/src/duckstation-qt/debuggerwindow.cpp
+++ b/src/duckstation-qt/debuggerwindow.cpp
@@ -6,9 +6,12 @@
 #include "qthost.h"
 #include "qtutils.h"
 
-#include "common/assert.h"
+#include "core/bus.h"
+#include "core/cpu_code_cache.h"
 #include "core/cpu_core_private.h"
 
+#include "common/assert.h"
+
 #include <QtCore/QSignalBlocker>
 #include <QtGui/QCursor>
 #include <QtGui/QFontDatabase>
@@ -568,10 +571,27 @@ void DebuggerWindow::setMemoryViewRegion(Bus::MemoryRegion region)
 
   m_active_memory_region = region;
 
+  static constexpr auto edit_ram_callback = [](size_t offset, size_t count) {
+    // shouldn't happen
+    if (offset > Bus::g_ram_size)
+      return;
+
+    const u32 start_page = static_cast<u32>(offset) / HOST_PAGE_SIZE;
+    const u32 end_page = static_cast<u32>(offset + count - 1) / HOST_PAGE_SIZE;
+    for (u32 i = start_page; i <= end_page; i++)
+    {
+      if (Bus::g_ram_code_bits[i])
+        CPU::CodeCache::InvalidateBlocksWithPageIndex(i);
+    }
+  };
+
   const PhysicalMemoryAddress start = Bus::GetMemoryRegionStart(region);
   const PhysicalMemoryAddress end = Bus::GetMemoryRegionEnd(region);
-  m_ui.memoryView->setData(start, Bus::GetMemoryRegionPointer(region), end - start,
-                           Bus::IsMemoryRegionWritable(region));
+  void* const mem_ptr = Bus::GetMemoryRegionPointer(region);
+  const bool mem_writable = Bus::IsMemoryRegionWritable(region);
+  const MemoryViewWidget::EditCallback edit_callback =
+    ((region == Bus::MemoryRegion::RAM) ? edit_ram_callback : nullptr);
+  m_ui.memoryView->setData(start, mem_ptr, end - start, mem_writable, edit_callback);
 
 #define SET_REGION_RADIO_BUTTON(name, rb_region)                                                                       \
   do                                                                                                                   \
diff --git a/src/duckstation-qt/memoryviewwidget.cpp b/src/duckstation-qt/memoryviewwidget.cpp
index 5b4d5cbb1..90e857eed 100644
--- a/src/duckstation-qt/memoryviewwidget.cpp
+++ b/src/duckstation-qt/memoryviewwidget.cpp
@@ -8,7 +8,7 @@
 
 MemoryViewWidget::MemoryViewWidget(QWidget* parent /* = nullptr */, size_t address_offset /* = 0 */,
                                    void* data_ptr /* = nullptr */, size_t data_size /* = 0 */,
-                                   bool data_editable /* = false */)
+                                   bool data_editable /* = false */, EditCallback edit_callback /* = nullptr */)
   : QAbstractScrollArea(parent)
 {
   m_bytes_per_line = 16;
@@ -19,7 +19,7 @@ MemoryViewWidget::MemoryViewWidget(QWidget* parent /* = nullptr */, size_t addre
   connect(horizontalScrollBar(), &QScrollBar::valueChanged, this, &MemoryViewWidget::adjustContent);
 
   if (data_ptr)
-    setData(address_offset, data_ptr, data_size, data_editable);
+    setData(address_offset, data_ptr, data_size, data_editable, edit_callback);
 }
 
 MemoryViewWidget::~MemoryViewWidget() = default;
@@ -46,13 +46,15 @@ void MemoryViewWidget::updateMetrics()
   m_char_height = fm.height();
 }
 
-void MemoryViewWidget::setData(size_t address_offset, void* data_ptr, size_t data_size, bool data_editable)
+void MemoryViewWidget::setData(size_t address_offset, void* data_ptr, size_t data_size, bool data_editable,
+                               EditCallback edit_callback)
 {
   m_data = data_ptr;
   m_data_size = data_size;
   m_data_editable = data_editable;
   m_address_offset = address_offset;
   m_selected_address = INVALID_SELECTED_ADDRESS;
+  m_edit_callback = edit_callback;
   m_last_data_start_offset = 0;
   m_last_data.clear();
   adjustContent();
@@ -137,7 +139,15 @@ void MemoryViewWidget::keyPressEvent(QKeyEvent* event)
         if (m_selection_was_ascii)
         {
           expandCurrentDataToInclude(m_selected_address);
-          std::memcpy(static_cast<unsigned char*>(m_data) + m_selected_address, &ch, sizeof(unsigned char));
+
+          unsigned char* pdata = static_cast<unsigned char*>(m_data) + m_selected_address;
+          if (static_cast<unsigned char>(ch) != *pdata)
+          {
+            *pdata = static_cast<unsigned char>(ch);
+            if (m_edit_callback)
+              m_edit_callback(m_selected_address, 1);
+          }
+
           m_selected_address = std::min(m_selected_address + 1, m_data_size - 1);
           forceRefresh();
         }
@@ -157,7 +167,14 @@ void MemoryViewWidget::keyPressEvent(QKeyEvent* event)
             expandCurrentDataToInclude(m_selected_address);
 
             unsigned char* pdata = static_cast<unsigned char*>(m_data) + m_selected_address;
-            *pdata = (*pdata & ~(0xf0 >> (m_editing_nibble * 4))) | (nibble << ((1 - m_editing_nibble) * 4));
+            const unsigned char new_value =
+              (*pdata & ~(0xf0 >> (m_editing_nibble * 4))) | (nibble << ((1 - m_editing_nibble) * 4));
+            if (*pdata != new_value)
+            {
+              *pdata = new_value;
+              if (m_edit_callback)
+                m_edit_callback(m_selected_address, 1);
+            }
 
             if (m_editing_nibble == 1)
             {
diff --git a/src/duckstation-qt/memoryviewwidget.h b/src/duckstation-qt/memoryviewwidget.h
index 2f6209bf6..313b04e7c 100644
--- a/src/duckstation-qt/memoryviewwidget.h
+++ b/src/duckstation-qt/memoryviewwidget.h
@@ -9,16 +9,18 @@
 
 class MemoryViewWidget : public QAbstractScrollArea
 {
-public:
   Q_OBJECT
+
 public:
+  using EditCallback = void (*)(size_t offset, size_t bytes);
+
   MemoryViewWidget(QWidget* parent = nullptr, size_t address_offset = 0, void* data_ptr = nullptr, size_t data_size = 0,
-                   bool data_editable = false);
+                   bool data_editable = false, EditCallback edit_callback = nullptr);
   ~MemoryViewWidget();
 
   size_t addressOffset() const { return m_address_offset; }
 
-  void setData(size_t address_offset, void* data_ptr, size_t data_size, bool data_editable);
+  void setData(size_t address_offset, void* data_ptr, size_t data_size, bool data_editable, EditCallback edit_callback);
   void setHighlightRange(size_t start, size_t end);
   void clearHighlightRange();
   void scrolltoOffset(size_t offset);
@@ -71,6 +73,7 @@ private:
 
   int m_rows_visible;
 
+  EditCallback m_edit_callback = nullptr;
   std::vector<u8> m_last_data;
   size_t m_last_data_start_offset = 0;
 };
\ No newline at end of file