diff --git a/src/common/layered_settings_interface.h b/src/common/layered_settings_interface.h
index 3a89b5960..3d25f104a 100644
--- a/src/common/layered_settings_interface.h
+++ b/src/common/layered_settings_interface.h
@@ -10,7 +10,6 @@ class LayeredSettingsInterface final : public SettingsInterface
 public:
   enum Layer : u32
   {
-    LAYER_CMDLINE,
     LAYER_GAME,
     LAYER_INPUT,
     LAYER_BASE,
@@ -66,7 +65,7 @@ public:
   using SettingsInterface::GetUIntValue;
 
 private:
-  static constexpr Layer FIRST_LAYER = LAYER_CMDLINE;
+  static constexpr Layer FIRST_LAYER = LAYER_GAME;
   static constexpr Layer LAST_LAYER = LAYER_BASE;
 
   std::array<SettingsInterface*, NUM_LAYERS> m_layers{};
diff --git a/src/common/memory_settings_interface.h b/src/common/memory_settings_interface.h
index 612abf202..b1ca083b4 100644
--- a/src/common/memory_settings_interface.h
+++ b/src/common/memory_settings_interface.h
@@ -10,7 +10,7 @@ class MemorySettingsInterface final : public SettingsInterface
 {
 public:
   MemorySettingsInterface();
-  ~MemorySettingsInterface();
+  ~MemorySettingsInterface() override;
 
   bool Save(Error* error = nullptr) override;
 
diff --git a/src/core/fullscreen_ui.cpp b/src/core/fullscreen_ui.cpp
index 0b9358470..b6af1755a 100644
--- a/src/core/fullscreen_ui.cpp
+++ b/src/core/fullscreen_ui.cpp
@@ -2798,7 +2798,7 @@ void FullscreenUI::DoCopyGameSettings()
     return;
 
   Settings temp_settings;
-  temp_settings.Load(*GetEditingSettingsInterface(false));
+  temp_settings.Load(*GetEditingSettingsInterface(false), *GetEditingSettingsInterface(false));
   temp_settings.Save(*s_game_settings_interface, true);
   SetSettingsChanged(s_game_settings_interface.get());
 
@@ -3652,20 +3652,20 @@ void FullscreenUI::DrawControllerSettingsPage()
   if (IsEditingGameSettings(bsi))
   {
     if (DrawToggleSetting(bsi, FSUI_ICONSTR(ICON_FA_COG, "Per-Game Configuration"),
-                          FSUI_CSTR("Uses game-specific settings for controllers for this game."), "Pad",
+                          FSUI_CSTR("Uses game-specific settings for controllers for this game."), "ControllerPorts",
                           "UseGameSettingsForController", false, IsEditingGameSettings(bsi), false))
     {
       // did we just enable per-game for the first time?
-      if (bsi->GetBoolValue("Pad", "UseGameSettingsForController", false) &&
-          !bsi->GetBoolValue("Pad", "GameSettingsInitialized", false))
+      if (bsi->GetBoolValue("ControllerPorts", "UseGameSettingsForController", false) &&
+          !bsi->GetBoolValue("ControllerPorts", "GameSettingsInitialized", false))
       {
-        bsi->SetBoolValue("Pad", "GameSettingsInitialized", true);
+        bsi->SetBoolValue("ControllerPorts", "GameSettingsInitialized", true);
         CopyGlobalControllerSettingsToGame();
       }
     }
   }
 
-  if (IsEditingGameSettings(bsi) && !bsi->GetBoolValue("Pad", "UseGameSettingsForController", false))
+  if (IsEditingGameSettings(bsi) && !bsi->GetBoolValue("ControllerPorts", "UseGameSettingsForController", false))
   {
     // nothing to edit..
     EndMenuButtons();
diff --git a/src/core/settings.cpp b/src/core/settings.cpp
index dc34e6c06..db23ed84e 100644
--- a/src/core/settings.cpp
+++ b/src/core/settings.cpp
@@ -134,7 +134,7 @@ void Settings::UpdateOverclockActive()
   cpu_overclock_active = (cpu_overclock_enable && (cpu_overclock_numerator != 1 || cpu_overclock_denominator != 1));
 }
 
-void Settings::Load(SettingsInterface& si)
+void Settings::Load(SettingsInterface& si, SettingsInterface& controller_si)
 {
   region =
     ParseConsoleRegionName(
@@ -364,7 +364,8 @@ void Settings::Load(SettingsInterface& si)
 
   multitap_mode =
     ParseMultitapModeName(
-      si.GetStringValue("ControllerPorts", "MultitapMode", GetMultitapModeName(DEFAULT_MULTITAP_MODE)).c_str())
+      controller_si.GetStringValue("ControllerPorts", "MultitapMode", GetMultitapModeName(DEFAULT_MULTITAP_MODE))
+        .c_str())
       .value_or(DEFAULT_MULTITAP_MODE);
 
   const std::array<bool, 2> mtap_enabled = {{IsPort1MultitapEnabled(), IsPort2MultitapEnabled()}};
@@ -379,7 +380,7 @@ void Settings::Load(SettingsInterface& si)
     }
 
     const ControllerType default_type = (i == 0) ? DEFAULT_CONTROLLER_1_TYPE : DEFAULT_CONTROLLER_2_TYPE;
-    const Controller::ControllerInfo* cinfo = Controller::GetControllerInfo(si.GetTinyStringValue(
+    const Controller::ControllerInfo* cinfo = Controller::GetControllerInfo(controller_si.GetTinyStringValue(
       Controller::GetSettingsSection(i).c_str(), "Type", Controller::GetControllerInfo(default_type)->name));
     controller_types[i] = cinfo ? cinfo->type : default_type;
   }
diff --git a/src/core/settings.h b/src/core/settings.h
index 492eef216..3a0390642 100644
--- a/src/core/settings.h
+++ b/src/core/settings.h
@@ -354,7 +354,7 @@ struct Settings
     DEFAULT_VRAM_WRITE_DUMP_HEIGHT_THRESHOLD = 128,
   };
 
-  void Load(SettingsInterface& si);
+  void Load(SettingsInterface& si, SettingsInterface& controller_si);
   void Save(SettingsInterface& si, bool ignore_base) const;
   static void Clear(SettingsInterface& si);
 
diff --git a/src/core/system.cpp b/src/core/system.cpp
index e5a445036..628121553 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -54,6 +54,7 @@
 #include "common/dynamic_library.h"
 #include "common/error.h"
 #include "common/file_system.h"
+#include "common/layered_settings_interface.h"
 #include "common/log.h"
 #include "common/path.h"
 #include "common/string_util.h"
@@ -136,7 +137,8 @@ struct MemorySaveState
 static void CheckCacheLineSize();
 static void LogStartupInformation();
 
-static void LoadInputBindings(SettingsInterface& si, std::unique_lock<std::mutex>& lock);
+static LayeredSettingsInterface GetControllerSettingsLayers(std::unique_lock<std::mutex>& lock);
+static LayeredSettingsInterface GetHotkeySettingsLayer(std::unique_lock<std::mutex>& lock);
 
 static std::string GetExecutableNameForImage(IsoReader& iso, bool strip_subdirectories);
 static bool ReadExecutableFromImage(IsoReader& iso, std::string* out_executable_name,
@@ -1202,12 +1204,14 @@ void System::LoadSettings(bool display_osd_messages)
 {
   std::unique_lock<std::mutex> lock = Host::GetSettingsLock();
   SettingsInterface& si = *Host::GetSettingsInterface();
-  g_settings.Load(si);
+  LayeredSettingsInterface controller_si = GetControllerSettingsLayers(lock);
+  LayeredSettingsInterface hotkey_si = GetHotkeySettingsLayer(lock);
+  g_settings.Load(si, controller_si);
   g_settings.UpdateLogSettings();
 
   Host::LoadSettings(si, lock);
-  InputManager::ReloadSources(si, lock);
-  LoadInputBindings(si, lock);
+  InputManager::ReloadSources(controller_si, lock);
+  InputManager::ReloadBindings(controller_si, hotkey_si);
   WarnAboutUnsafeSettings();
 
   // apply compatibility settings
@@ -1224,12 +1228,15 @@ void System::LoadSettings(bool display_osd_messages)
 void System::ReloadInputSources()
 {
   std::unique_lock<std::mutex> lock = Host::GetSettingsLock();
-  SettingsInterface* si = Host::GetSettingsInterface();
-  InputManager::ReloadSources(*si, lock);
+  LayeredSettingsInterface controller_si = GetControllerSettingsLayers(lock);
+  InputManager::ReloadSources(controller_si, lock);
 
   // skip loading bindings if we're not running, since it'll get done on startup anyway
   if (IsValid())
-    LoadInputBindings(*si, lock);
+  {
+    LayeredSettingsInterface hotkey_si = GetHotkeySettingsLayer(lock);
+    InputManager::ReloadBindings(controller_si, hotkey_si);
+  }
 }
 
 void System::ReloadInputBindings()
@@ -1239,37 +1246,43 @@ void System::ReloadInputBindings()
     return;
 
   std::unique_lock<std::mutex> lock = Host::GetSettingsLock();
-  SettingsInterface* si = Host::GetSettingsInterface();
-  LoadInputBindings(*si, lock);
+  LayeredSettingsInterface controller_si = GetControllerSettingsLayers(lock);
+  LayeredSettingsInterface hotkey_si = GetHotkeySettingsLayer(lock);
+  InputManager::ReloadBindings(controller_si, hotkey_si);
 }
 
-void System::LoadInputBindings(SettingsInterface& si, std::unique_lock<std::mutex>& lock)
+LayeredSettingsInterface System::GetControllerSettingsLayers(std::unique_lock<std::mutex>& lock)
 {
-  // Hotkeys use the base configuration, except if the custom hotkeys option is enabled.
+  LayeredSettingsInterface ret;
+  ret.SetLayer(LayeredSettingsInterface::Layer::LAYER_BASE, Host::Internal::GetBaseSettingsLayer());
+
+  // Select input profile _or_ game settings, not both.
   if (SettingsInterface* isi = Host::Internal::GetInputSettingsLayer())
   {
-    const bool use_profile_hotkeys = isi->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false);
-    if (use_profile_hotkeys)
-    {
-      InputManager::ReloadBindings(si, *isi, *isi);
-    }
-    else
-    {
-      // Temporarily disable the input profile layer, so it doesn't take precedence.
-      Host::Internal::SetInputSettingsLayer(nullptr, lock);
-      InputManager::ReloadBindings(si, *isi, si);
-      Host::Internal::SetInputSettingsLayer(s_input_settings_interface.get(), lock);
-    }
+    ret.SetLayer(LayeredSettingsInterface::Layer::LAYER_INPUT, Host::Internal::GetInputSettingsLayer());
   }
   else if (SettingsInterface* gsi = Host::Internal::GetGameSettingsLayer();
            gsi && gsi->GetBoolValue("ControllerPorts", "UseGameSettingsForController", false))
   {
-    InputManager::ReloadBindings(si, *gsi, si);
+    ret.SetLayer(LayeredSettingsInterface::Layer::LAYER_GAME, gsi);
   }
-  else
+
+  return ret;
+}
+
+LayeredSettingsInterface System::GetHotkeySettingsLayer(std::unique_lock<std::mutex>& lock)
+{
+  LayeredSettingsInterface ret;
+  ret.SetLayer(LayeredSettingsInterface::Layer::LAYER_BASE, Host::Internal::GetBaseSettingsLayer());
+
+  // Only add input profile layer if the option is enabled.
+  if (SettingsInterface* isi = Host::Internal::GetInputSettingsLayer();
+      isi && isi->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false))
   {
-    InputManager::ReloadBindings(si, si, si);
+    ret.SetLayer(LayeredSettingsInterface::Layer::LAYER_INPUT, Host::Internal::GetInputSettingsLayer());
   }
+
+  return ret;
 }
 
 void System::SetDefaultSettings(SettingsInterface& si)
diff --git a/src/duckstation-qt/controllerbindingwidgets.cpp b/src/duckstation-qt/controllerbindingwidgets.cpp
index 10cb21e59..9f05db321 100644
--- a/src/duckstation-qt/controllerbindingwidgets.cpp
+++ b/src/duckstation-qt/controllerbindingwidgets.cpp
@@ -247,7 +247,7 @@ void ControllerBindingWidget::onTypeChanged()
   m_controller_info = Controller::GetControllerInfo(static_cast<ControllerType>(index));
   DebugAssert(m_controller_info);
 
-  SettingsInterface* sif = m_dialog->getProfileSettingsInterface();
+  SettingsInterface* sif = m_dialog->getEditingSettingsInterface();
   if (sif)
   {
     sif->SetStringValue(m_config_section.c_str(), "Type", m_controller_info->name);
@@ -307,7 +307,7 @@ void ControllerBindingWidget::onClearBindingsClicked()
   }
   else
   {
-    InputManager::ClearPortBindings(*m_dialog->getProfileSettingsInterface(), m_port_number);
+    InputManager::ClearPortBindings(*m_dialog->getEditingSettingsInterface(), m_port_number);
   }
 
   saveAndRefresh();
@@ -358,8 +358,8 @@ void ControllerBindingWidget::doDeviceAutomaticBinding(const QString& device)
   }
   else
   {
-    result = InputManager::MapController(*m_dialog->getProfileSettingsInterface(), m_port_number, mapping);
-    QtHost::SaveGameSettings(m_dialog->getProfileSettingsInterface(), false);
+    result = InputManager::MapController(*m_dialog->getEditingSettingsInterface(), m_port_number, mapping);
+    QtHost::SaveGameSettings(m_dialog->getEditingSettingsInterface(), false);
     g_emu_thread->reloadInputBindings();
   }
 
@@ -377,7 +377,7 @@ void ControllerBindingWidget::saveAndRefresh()
 
 void ControllerBindingWidget::createBindingWidgets(QWidget* parent)
 {
-  SettingsInterface* sif = getDialog()->getProfileSettingsInterface();
+  SettingsInterface* sif = getDialog()->getEditingSettingsInterface();
   DebugAssert(m_controller_info);
 
   QGroupBox* axis_gbox = nullptr;
@@ -471,7 +471,7 @@ void ControllerBindingWidget::createBindingWidgets(QWidget* parent)
 
 void ControllerBindingWidget::bindBindingWidgets(QWidget* parent)
 {
-  SettingsInterface* sif = getDialog()->getProfileSettingsInterface();
+  SettingsInterface* sif = getDialog()->getEditingSettingsInterface();
   DebugAssert(m_controller_info);
 
   const std::string& config_section = getConfigSection();
@@ -601,12 +601,12 @@ ControllerMacroEditWidget::ControllerMacroEditWidget(ControllerMacroWidget* pare
   }
 
   m_frequency = dialog->getIntValue(section.c_str(), TinyString::from_format("Macro{}Frequency", index + 1u), 0);
-  ControllerSettingWidgetBinder::BindWidgetToInputProfileBool(dialog->getProfileSettingsInterface(), m_ui.triggerToggle,
+  ControllerSettingWidgetBinder::BindWidgetToInputProfileBool(dialog->getEditingSettingsInterface(), m_ui.triggerToggle,
                                                               section.c_str(), fmt::format("Macro{}Toggle", index + 1u),
                                                               false);
   updateFrequencyText();
 
-  m_ui.trigger->initialize(dialog->getProfileSettingsInterface(), InputBindingInfo::Type::Macro, section,
+  m_ui.trigger->initialize(dialog->getEditingSettingsInterface(), InputBindingInfo::Type::Macro, section,
                            fmt::format("Macro{}", index + 1u));
 
   connect(m_ui.increaseFrequency, &QAbstractButton::clicked, this, [this]() { modFrequency(1); });
@@ -747,7 +747,7 @@ void ControllerCustomSettingsWidget::createSettingWidgets(ControllerBindingWidge
                                                           QGridLayout* layout, const Controller::ControllerInfo* cinfo)
 {
   const std::string& section = parent->getConfigSection();
-  SettingsInterface* sif = parent->getDialog()->getProfileSettingsInterface();
+  SettingsInterface* sif = parent->getDialog()->getEditingSettingsInterface();
   int current_row = 0;
 
   for (const SettingInfo& si : cinfo->settings)
diff --git a/src/duckstation-qt/controllerglobalsettingswidget.cpp b/src/duckstation-qt/controllerglobalsettingswidget.cpp
index 53a1077c9..0d64005de 100644
--- a/src/duckstation-qt/controllerglobalsettingswidget.cpp
+++ b/src/duckstation-qt/controllerglobalsettingswidget.cpp
@@ -14,7 +14,7 @@ ControllerGlobalSettingsWidget::ControllerGlobalSettingsWidget(QWidget* parent,
 {
   m_ui.setupUi(this);
 
-  SettingsInterface* sif = dialog->getProfileSettingsInterface();
+  SettingsInterface* sif = dialog->getEditingSettingsInterface();
 
   SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.enableSDLSource, "InputSources", "SDL", true);
   SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.enableSDLEnhancedMode, "InputSources",
@@ -28,10 +28,10 @@ ControllerGlobalSettingsWidget::ControllerGlobalSettingsWidget(QWidget* parent,
   SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.enableSDLMFIDriver, "InputSources", "SDLMFIDriver", true);
 #else
   m_ui.sdlGridLayout->removeWidget(m_ui.enableSDLIOKitDriver);
-  m_ui.enableSDLIOKitDriver->deleteLater();
+  delete m_ui.enableSDLIOKitDriver;
   m_ui.enableSDLIOKitDriver = nullptr;
   m_ui.sdlGridLayout->removeWidget(m_ui.enableSDLMFIDriver);
-  m_ui.enableSDLMFIDriver->deleteLater();
+  delete m_ui.enableSDLMFIDriver;
   m_ui.enableSDLMFIDriver = nullptr;
 #endif
 
@@ -41,10 +41,10 @@ ControllerGlobalSettingsWidget::ControllerGlobalSettingsWidget(QWidget* parent,
   SettingWidgetBinder::BindWidgetToBoolSetting(sif, m_ui.enableRawInput, "InputSources", "RawInput", false);
 #else
   m_ui.mainLayout->removeWidget(m_ui.xinputGroup);
-  m_ui.xinputGroup->deleteLater();
+  delete m_ui.xinputGroup;
   m_ui.xinputGroup = nullptr;
   m_ui.mainLayout->removeWidget(m_ui.dinputGroup);
-  m_ui.dinputGroup->deleteLater();
+  delete m_ui.dinputGroup;
   m_ui.dinputGroup = nullptr;
 #endif
 
@@ -71,10 +71,13 @@ ControllerGlobalSettingsWidget::ControllerGlobalSettingsWidget(QWidget* parent,
   {
     // remove profile options from the UI.
     m_ui.mainLayout->removeWidget(m_ui.profileSettings);
-    m_ui.profileSettings->deleteLater();
+    delete m_ui.profileSettings;
     m_ui.profileSettings = nullptr;
   }
 
+  if (dialog->isEditingGameSettings())
+    m_ui.deviceListGroup->setEnabled(false);
+
   connect(m_ui.multitapMode, &QComboBox::currentIndexChanged, this, [this]() { emit bindingSetupChanged(); });
 
   connect(m_ui.pointerXScale, &QSlider::valueChanged, this,
@@ -134,9 +137,10 @@ ControllerLEDSettingsDialog::ControllerLEDSettingsDialog(QWidget* parent, Contro
   linkButton(m_ui.SDL2LED, 2);
   linkButton(m_ui.SDL3LED, 3);
 
-  SettingsInterface* sif = dialog->getProfileSettingsInterface();
+  SettingsInterface* sif = dialog->getEditingSettingsInterface();
 
-  ControllerSettingWidgetBinder::BindWidgetToInputProfileBool(sif, m_ui.enableSDLPS5PlayerLED, "InputSources", "SDLPS5PlayerLED", false);
+  ControllerSettingWidgetBinder::BindWidgetToInputProfileBool(sif, m_ui.enableSDLPS5PlayerLED, "InputSources",
+                                                              "SDLPS5PlayerLED", false);
   connect(m_ui.buttonBox->button(QDialogButtonBox::Close), &QPushButton::clicked, this, &QDialog::accept);
 }
 
diff --git a/src/duckstation-qt/controllerglobalsettingswidget.ui b/src/duckstation-qt/controllerglobalsettingswidget.ui
index 749d0b844..abf4160b2 100644
--- a/src/duckstation-qt/controllerglobalsettingswidget.ui
+++ b/src/duckstation-qt/controllerglobalsettingswidget.ui
@@ -50,7 +50,7 @@
     </widget>
    </item>
    <item row="0" column="1" rowspan="7">
-    <widget class="QGroupBox" name="groupBox_3">
+    <widget class="QGroupBox" name="deviceListGroup">
      <property name="title">
       <string>Detected Devices</string>
      </property>
@@ -162,8 +162,7 @@
            <string>Controller LED Settings</string>
           </property>
           <property name="icon">
-           <iconset theme="lightbulb-line">
-            <normaloff>.</normaloff>.</iconset>
+           <iconset theme="lightbulb-line"/>
           </property>
          </widget>
         </item>
@@ -284,7 +283,7 @@
            <number>30</number>
           </property>
           <property name="orientation">
-           <enum>Qt::Horizontal</enum>
+           <enum>Qt::Orientation::Horizontal</enum>
           </property>
          </widget>
         </item>
@@ -339,7 +338,7 @@
            <number>30</number>
           </property>
           <property name="orientation">
-           <enum>Qt::Horizontal</enum>
+           <enum>Qt::Orientation::Horizontal</enum>
           </property>
          </widget>
         </item>
@@ -388,7 +387,7 @@
    <item row="6" column="0">
     <spacer name="verticalSpacer">
      <property name="orientation">
-      <enum>Qt::Vertical</enum>
+      <enum>Qt::Orientation::Vertical</enum>
      </property>
      <property name="sizeHint" stdset="0">
       <size>
diff --git a/src/duckstation-qt/controllersettingswindow.cpp b/src/duckstation-qt/controllersettingswindow.cpp
index 59a31efbb..3da41c4d2 100644
--- a/src/duckstation-qt/controllersettingswindow.cpp
+++ b/src/duckstation-qt/controllersettingswindow.cpp
@@ -23,41 +23,87 @@
 
 static constexpr const std::array<char, 4> s_mtap_slot_names = {{'A', 'B', 'C', 'D'}};
 
-ControllerSettingsWindow::ControllerSettingsWindow() : QWidget()
+ControllerSettingsWindow::ControllerSettingsWindow(SettingsInterface* game_sif /* = nullptr */,
+                                                   QWidget* parent /* = nullptr */)
+  : QWidget(parent), m_editing_settings_interface(game_sif)
 {
   m_ui.setupUi(this);
 
   setWindowFlags(windowFlags() & ~Qt::WindowContextHelpButtonHint);
 
-  refreshProfileList();
-  createWidgets();
-
   m_ui.settingsCategory->setSizePolicy(QSizePolicy::Minimum, QSizePolicy::Minimum);
+
   connect(m_ui.settingsCategory, &QListWidget::currentRowChanged, this,
           &ControllerSettingsWindow::onCategoryCurrentRowChanged);
-  connect(m_ui.currentProfile, &QComboBox::currentIndexChanged, this,
-          &ControllerSettingsWindow::onCurrentProfileChanged);
   connect(m_ui.buttonBox, &QDialogButtonBox::rejected, this, &ControllerSettingsWindow::close);
-  connect(m_ui.newProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onNewProfileClicked);
-  connect(m_ui.applyProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onApplyProfileClicked);
-  connect(m_ui.deleteProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onDeleteProfileClicked);
-  connect(m_ui.restoreDefaults, &QPushButton::clicked, this, &ControllerSettingsWindow::onRestoreDefaultsClicked);
 
-  connect(g_emu_thread, &EmuThread::onInputDevicesEnumerated, this,
-          &ControllerSettingsWindow::onInputDevicesEnumerated);
-  connect(g_emu_thread, &EmuThread::onInputDeviceConnected, this, &ControllerSettingsWindow::onInputDeviceConnected);
-  connect(g_emu_thread, &EmuThread::onInputDeviceDisconnected, this,
-          &ControllerSettingsWindow::onInputDeviceDisconnected);
-  connect(g_emu_thread, &EmuThread::onVibrationMotorsEnumerated, this,
-          &ControllerSettingsWindow::onVibrationMotorsEnumerated);
+  if (!game_sif)
+  {
+    refreshProfileList();
 
-  // trigger a device enumeration to populate the device list
-  g_emu_thread->enumerateInputDevices();
-  g_emu_thread->enumerateVibrationMotors();
+    m_ui.editProfileLayout->removeWidget(m_ui.copyGlobalSettings);
+    delete m_ui.copyGlobalSettings;
+    m_ui.copyGlobalSettings = nullptr;
+
+    connect(m_ui.currentProfile, &QComboBox::currentIndexChanged, this,
+            &ControllerSettingsWindow::onCurrentProfileChanged);
+    connect(m_ui.newProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onNewProfileClicked);
+    connect(m_ui.applyProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onApplyProfileClicked);
+    connect(m_ui.deleteProfile, &QPushButton::clicked, this, &ControllerSettingsWindow::onDeleteProfileClicked);
+    connect(m_ui.restoreDefaults, &QPushButton::clicked, this, &ControllerSettingsWindow::onRestoreDefaultsClicked);
+
+    connect(g_emu_thread, &EmuThread::onInputDevicesEnumerated, this,
+            &ControllerSettingsWindow::onInputDevicesEnumerated);
+    connect(g_emu_thread, &EmuThread::onInputDeviceConnected, this, &ControllerSettingsWindow::onInputDeviceConnected);
+    connect(g_emu_thread, &EmuThread::onInputDeviceDisconnected, this,
+            &ControllerSettingsWindow::onInputDeviceDisconnected);
+    connect(g_emu_thread, &EmuThread::onVibrationMotorsEnumerated, this,
+            &ControllerSettingsWindow::onVibrationMotorsEnumerated);
+
+    // trigger a device enumeration to populate the device list
+    g_emu_thread->enumerateInputDevices();
+    g_emu_thread->enumerateVibrationMotors();
+  }
+  else
+  {
+    m_ui.editProfileLayout->removeWidget(m_ui.editProfileLabel);
+    delete m_ui.editProfileLabel;
+    m_ui.editProfileLabel = nullptr;
+    m_ui.editProfileLayout->removeWidget(m_ui.currentProfile);
+    delete m_ui.currentProfile;
+    m_ui.currentProfile = nullptr;
+    m_ui.editProfileLayout->removeWidget(m_ui.newProfile);
+    delete m_ui.newProfile;
+    m_ui.newProfile = nullptr;
+    m_ui.editProfileLayout->removeWidget(m_ui.applyProfile);
+    delete m_ui.applyProfile;
+    m_ui.applyProfile = nullptr;
+    m_ui.editProfileLayout->removeWidget(m_ui.deleteProfile);
+    delete m_ui.deleteProfile;
+    m_ui.deleteProfile = nullptr;
+
+    connect(m_ui.copyGlobalSettings, &QPushButton::clicked, this,
+            &ControllerSettingsWindow::onCopyGlobalSettingsClicked);
+    connect(m_ui.restoreDefaults, &QPushButton::clicked, this,
+            &ControllerSettingsWindow::onRestoreDefaultsForGameClicked);
+  }
+
+  createWidgets();
 }
 
 ControllerSettingsWindow::~ControllerSettingsWindow() = default;
 
+void ControllerSettingsWindow::editControllerSettingsForGame(QWidget* parent, SettingsInterface* sif)
+{
+  ControllerSettingsWindow* dlg = new ControllerSettingsWindow(sif, parent);
+  dlg->setWindowFlag(Qt::Window);
+  dlg->setAttribute(Qt::WA_DeleteOnClose);
+  dlg->setWindowModality(Qt::WindowModality::WindowModal);
+  dlg->setWindowTitle(parent->windowTitle());
+  dlg->setWindowIcon(parent->windowIcon());
+  dlg->show();
+}
+
 int ControllerSettingsWindow::getHotkeyCategoryIndex() const
 {
   const std::array<bool, 2> mtap_enabled = getEnabledMultitaps();
@@ -103,20 +149,26 @@ void ControllerSettingsWindow::onCategoryCurrentRowChanged(int row)
 
 void ControllerSettingsWindow::onCurrentProfileChanged(int index)
 {
-  switchProfile((index == 0) ? 0 : m_ui.currentProfile->itemText(index));
+  std::string profile_name;
+  if (index > 0)
+    profile_name = m_ui.currentProfile->itemText(index).toStdString();
+
+  switchProfile(profile_name);
 }
 
 void ControllerSettingsWindow::onNewProfileClicked()
 {
-  const QString profile_name(
-    QInputDialog::getText(this, tr("Create Input Profile"), tr("Enter the name for the new input profile:")));
-  if (profile_name.isEmpty())
+  const std::string profile_name =
+    QInputDialog::getText(this, tr("Create Input Profile"), tr("Enter the name for the new input profile:"))
+      .toStdString();
+  if (profile_name.empty())
     return;
 
-  std::string profile_path(System::GetInputProfilePath(profile_name.toStdString()));
+  std::string profile_path = System::GetInputProfilePath(profile_name);
   if (FileSystem::FileExists(profile_path.c_str()))
   {
-    QMessageBox::critical(this, tr("Error"), tr("A profile with the name '%1' already exists.").arg(profile_name));
+    QMessageBox::critical(this, tr("Error"),
+                          tr("A profile with the name '%1' already exists.").arg(QString::fromStdString(profile_name)));
     return;
   }
 
@@ -131,7 +183,7 @@ void ControllerSettingsWindow::onNewProfileClicked()
   if (res == QMessageBox::Yes)
   {
     // copy from global or the current profile
-    if (!m_profile_interface)
+    if (!m_editing_settings_interface)
     {
       const int hkres = QMessageBox::question(
         this, tr("Create Input Profile"),
@@ -153,9 +205,9 @@ void ControllerSettingsWindow::onNewProfileClicked()
     {
       // from profile
       const bool copy_hotkey_bindings =
-        m_profile_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false);
+        m_editing_settings_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false);
       temp_si.SetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", copy_hotkey_bindings);
-      InputManager::CopyConfiguration(&temp_si, *m_profile_interface, true, true, copy_hotkey_bindings);
+      InputManager::CopyConfiguration(&temp_si, *m_editing_settings_interface, true, true, copy_hotkey_bindings);
     }
   }
 
@@ -184,9 +236,9 @@ void ControllerSettingsWindow::onApplyProfileClicked()
 
   {
     const bool copy_hotkey_bindings =
-      m_profile_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false);
+      m_editing_settings_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false);
     auto lock = Host::GetSettingsLock();
-    InputManager::CopyConfiguration(Host::Internal::GetBaseSettingsLayer(), *m_profile_interface, true, true,
+    InputManager::CopyConfiguration(Host::Internal::GetBaseSettingsLayer(), *m_editing_settings_interface, true, true,
                                     copy_hotkey_bindings);
     QtHost::QueueSettingsSave();
   }
@@ -236,6 +288,36 @@ void ControllerSettingsWindow::onRestoreDefaultsClicked()
   switchProfile({});
 }
 
+void ControllerSettingsWindow::onCopyGlobalSettingsClicked()
+{
+  DebugAssert(isEditingGameSettings());
+
+  {
+    const auto lock = Host::GetSettingsLock();
+    InputManager::CopyConfiguration(m_editing_settings_interface, *Host::Internal::GetBaseSettingsLayer(), true, true,
+                                    false);
+  }
+
+  m_editing_settings_interface->Save();
+  g_emu_thread->reloadGameSettings();
+  createWidgets();
+
+  QMessageBox::information(QtUtils::GetRootWidget(this), tr("DuckStation Controller Settings"),
+                           tr("Per-game controller configuration reset to global settings."));
+}
+
+void ControllerSettingsWindow::onRestoreDefaultsForGameClicked()
+{
+  DebugAssert(isEditingGameSettings());
+  Settings::SetDefaultControllerConfig(*m_editing_settings_interface);
+  m_editing_settings_interface->Save();
+  g_emu_thread->reloadGameSettings();
+  createWidgets();
+
+  QMessageBox::information(QtUtils::GetRootWidget(this), tr("DuckStation Controller Settings"),
+                           tr("Per-game controller configuration reset to default settings."));
+}
+
 void ControllerSettingsWindow::onInputDevicesEnumerated(const std::vector<std::pair<std::string, std::string>>& devices)
 {
   m_device_list = devices;
@@ -280,16 +362,16 @@ void ControllerSettingsWindow::onVibrationMotorsEnumerated(const QList<InputBind
 
 bool ControllerSettingsWindow::getBoolValue(const char* section, const char* key, bool default_value) const
 {
-  if (m_profile_interface)
-    return m_profile_interface->GetBoolValue(section, key, default_value);
+  if (m_editing_settings_interface)
+    return m_editing_settings_interface->GetBoolValue(section, key, default_value);
   else
     return Host::GetBaseBoolSettingValue(section, key, default_value);
 }
 
 s32 ControllerSettingsWindow::getIntValue(const char* section, const char* key, s32 default_value) const
 {
-  if (m_profile_interface)
-    return m_profile_interface->GetIntValue(section, key, default_value);
+  if (m_editing_settings_interface)
+    return m_editing_settings_interface->GetIntValue(section, key, default_value);
   else
     return Host::GetBaseIntSettingValue(section, key, default_value);
 }
@@ -298,8 +380,8 @@ std::string ControllerSettingsWindow::getStringValue(const char* section, const
                                                      const char* default_value) const
 {
   std::string value;
-  if (m_profile_interface)
-    value = m_profile_interface->GetStringValue(section, key, default_value);
+  if (m_editing_settings_interface)
+    value = m_editing_settings_interface->GetStringValue(section, key, default_value);
   else
     value = Host::GetBaseStringSettingValue(section, key, default_value);
   return value;
@@ -307,9 +389,9 @@ std::string ControllerSettingsWindow::getStringValue(const char* section, const
 
 void ControllerSettingsWindow::setBoolValue(const char* section, const char* key, bool value)
 {
-  if (m_profile_interface)
+  if (m_editing_settings_interface)
   {
-    m_profile_interface->SetBoolValue(section, key, value);
+    m_editing_settings_interface->SetBoolValue(section, key, value);
     saveAndReloadGameSettings();
   }
   else
@@ -322,9 +404,9 @@ void ControllerSettingsWindow::setBoolValue(const char* section, const char* key
 
 void ControllerSettingsWindow::setIntValue(const char* section, const char* key, s32 value)
 {
-  if (m_profile_interface)
+  if (m_editing_settings_interface)
   {
-    m_profile_interface->SetIntValue(section, key, value);
+    m_editing_settings_interface->SetIntValue(section, key, value);
     saveAndReloadGameSettings();
   }
   else
@@ -337,9 +419,9 @@ void ControllerSettingsWindow::setIntValue(const char* section, const char* key,
 
 void ControllerSettingsWindow::setStringValue(const char* section, const char* key, const char* value)
 {
-  if (m_profile_interface)
+  if (m_editing_settings_interface)
   {
-    m_profile_interface->SetStringValue(section, key, value);
+    m_editing_settings_interface->SetStringValue(section, key, value);
     saveAndReloadGameSettings();
   }
   else
@@ -352,17 +434,17 @@ void ControllerSettingsWindow::setStringValue(const char* section, const char* k
 
 void ControllerSettingsWindow::saveAndReloadGameSettings()
 {
-  DebugAssert(m_profile_interface);
-  QtHost::SaveGameSettings(m_profile_interface.get(), false);
+  DebugAssert(m_editing_settings_interface);
+  QtHost::SaveGameSettings(m_editing_settings_interface, false);
   g_emu_thread->reloadGameSettings(false);
 }
 
 void ControllerSettingsWindow::clearSettingValue(const char* section, const char* key)
 {
-  if (m_profile_interface)
+  if (m_editing_settings_interface)
   {
-    m_profile_interface->DeleteValue(section, key);
-    m_profile_interface->Save();
+    m_editing_settings_interface->DeleteValue(section, key);
+    m_editing_settings_interface->Save();
     g_emu_thread->reloadGameSettings();
   }
   else
@@ -434,7 +516,8 @@ void ControllerSettingsWindow::createWidgets()
   }
 
   // only add hotkeys if we're editing global settings
-  if (!m_profile_interface || m_profile_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false))
+  if (!m_editing_settings_interface ||
+      m_editing_settings_interface->GetBoolValue("ControllerPorts", "UseProfileHotkeyBindings", false))
   {
     QListWidgetItem* item = new QListWidgetItem();
     item->setText(tr("Hotkeys"));
@@ -444,9 +527,18 @@ void ControllerSettingsWindow::createWidgets()
     m_ui.settingsContainer->addWidget(m_hotkey_settings);
   }
 
-  m_ui.applyProfile->setEnabled(isEditingProfile());
-  m_ui.deleteProfile->setEnabled(isEditingProfile());
-  m_ui.restoreDefaults->setEnabled(isEditingGlobalSettings());
+  if (!isEditingGameSettings())
+  {
+    m_ui.applyProfile->setEnabled(isEditingProfile());
+    m_ui.deleteProfile->setEnabled(isEditingProfile());
+    m_ui.restoreDefaults->setEnabled(isEditingGlobalSettings());
+  }
+}
+
+void ControllerSettingsWindow::closeEvent(QCloseEvent* event)
+{
+  QWidget::closeEvent(event);
+  emit windowClosed();
 }
 
 void ControllerSettingsWindow::updateListDescription(u32 global_slot, ControllerBindingWidget* widget)
@@ -501,30 +593,36 @@ void ControllerSettingsWindow::refreshProfileList()
   }
 }
 
-void ControllerSettingsWindow::switchProfile(const QString& name)
+void ControllerSettingsWindow::switchProfile(const std::string_view name)
 {
   QSignalBlocker sb(m_ui.currentProfile);
 
-  if (!name.isEmpty())
+  if (!name.empty())
   {
-    std::string path(System::GetInputProfilePath(name.toStdString()));
+    const QString name_qstr = QtUtils::StringViewToQString(name);
+
+    std::string path = System::GetInputProfilePath(name);
     if (!FileSystem::FileExists(path.c_str()))
     {
-      QMessageBox::critical(this, tr("Error"), tr("The input profile named '%1' cannot be found.").arg(name));
+      QMessageBox::critical(this, tr("Error"), tr("The input profile named '%1' cannot be found.").arg(name_qstr));
       return;
     }
 
-    std::unique_ptr<INISettingsInterface> sif(std::make_unique<INISettingsInterface>(std::move(path)));
+    std::unique_ptr<INISettingsInterface> sif = std::make_unique<INISettingsInterface>(std::move(path));
     sif->Load();
-    m_profile_interface = std::move(sif);
-    m_ui.currentProfile->setCurrentIndex(m_ui.currentProfile->findText(name));
+
+    m_profile_settings_interface = std::move(sif);
+    m_editing_settings_interface = m_profile_settings_interface.get();
+    m_ui.currentProfile->setCurrentIndex(m_ui.currentProfile->findText(name_qstr));
+    m_profile_name = name_qstr;
   }
   else
   {
-    m_profile_interface.reset();
+    m_profile_settings_interface.reset();
+    m_editing_settings_interface = nullptr;
     m_ui.currentProfile->setCurrentIndex(0);
+    m_profile_name = QString();
   }
 
-  m_profile_name = name;
   createWidgets();
 }
diff --git a/src/duckstation-qt/controllersettingswindow.h b/src/duckstation-qt/controllersettingswindow.h
index 78ec50ee6..7f080d627 100644
--- a/src/duckstation-qt/controllersettingswindow.h
+++ b/src/duckstation-qt/controllersettingswindow.h
@@ -20,6 +20,8 @@
 #include <utility>
 #include <vector>
 
+class Error;
+
 class ControllerGlobalSettingsWidget;
 class ControllerBindingWidget;
 class HotkeySettingsWidget;
@@ -44,22 +46,33 @@ public:
     MAX_PORTS = 8
   };
 
-  ControllerSettingsWindow();
+  ControllerSettingsWindow(SettingsInterface* game_sif = nullptr, QWidget* parent = nullptr);
   ~ControllerSettingsWindow();
 
+  static void editControllerSettingsForGame(QWidget* parent, SettingsInterface* sif);
+
   ALWAYS_INLINE HotkeySettingsWidget* getHotkeySettingsWidget() const { return m_hotkey_settings; }
 
   ALWAYS_INLINE const std::vector<std::pair<std::string, std::string>>& getDeviceList() const { return m_device_list; }
   ALWAYS_INLINE const QStringList& getVibrationMotors() const { return m_vibration_motors; }
 
-  ALWAYS_INLINE bool isEditingGlobalSettings() const { return m_profile_name.isEmpty(); }
+  ALWAYS_INLINE bool isEditingGlobalSettings() const
+  {
+    return (m_profile_name.isEmpty() && !m_editing_settings_interface);
+  }
+  ALWAYS_INLINE bool isEditingGameSettings() const
+  {
+    return (m_profile_name.isEmpty() && m_editing_settings_interface);
+  }
   ALWAYS_INLINE bool isEditingProfile() const { return !m_profile_name.isEmpty(); }
-  ALWAYS_INLINE SettingsInterface* getProfileSettingsInterface() { return m_profile_interface.get(); }
+  ALWAYS_INLINE SettingsInterface* getEditingSettingsInterface() { return m_editing_settings_interface; }
 
   Category getCurrentCategory() const;
 
   void updateListDescription(u32 global_slot, ControllerBindingWidget* widget);
 
+  void switchProfile(const std::string_view name);
+
   // Helper functions for updating setting values globally or in the profile.
   bool getBoolValue(const char* section, const char* key, bool default_value) const;
   s32 getIntValue(const char* section, const char* key, s32 default_value) const;
@@ -71,6 +84,7 @@ public:
   void saveAndReloadGameSettings();
 
 Q_SIGNALS:
+  void windowClosed();
   void inputProfileSwitched();
 
 public Q_SLOTS:
@@ -83,6 +97,8 @@ private Q_SLOTS:
   void onApplyProfileClicked();
   void onDeleteProfileClicked();
   void onRestoreDefaultsClicked();
+  void onCopyGlobalSettingsClicked();
+  void onRestoreDefaultsForGameClicked();
 
   void onInputDevicesEnumerated(const std::vector<std::pair<std::string, std::string>>& devices);
   void onInputDeviceConnected(const std::string& identifier, const std::string& device_name);
@@ -91,15 +107,19 @@ private Q_SLOTS:
 
   void createWidgets();
 
+protected:
+  void closeEvent(QCloseEvent* event) override;
+
 private:
   int getHotkeyCategoryIndex() const;
   void refreshProfileList();
-  void switchProfile(const QString& name);
 
   std::array<bool, 2> getEnabledMultitaps() const;
 
   Ui::ControllerSettingsWindow m_ui;
 
+  SettingsInterface* m_editing_settings_interface = nullptr;
+
   ControllerGlobalSettingsWidget* m_global_settings = nullptr;
   std::array<ControllerBindingWidget*, MAX_PORTS> m_port_bindings{};
   HotkeySettingsWidget* m_hotkey_settings = nullptr;
@@ -108,5 +128,5 @@ private:
   QStringList m_vibration_motors;
 
   QString m_profile_name;
-  std::unique_ptr<SettingsInterface> m_profile_interface;
+  std::unique_ptr<SettingsInterface> m_profile_settings_interface;
 };
diff --git a/src/duckstation-qt/controllersettingswindow.ui b/src/duckstation-qt/controllersettingswindow.ui
index fa77a8495..0b63346e6 100644
--- a/src/duckstation-qt/controllersettingswindow.ui
+++ b/src/duckstation-qt/controllersettingswindow.ui
@@ -6,7 +6,7 @@
    <rect>
     <x>0</x>
     <y>0</y>
-    <width>1279</width>
+    <width>1284</width>
     <height>672</height>
    </rect>
   </property>
@@ -20,7 +20,7 @@
    <string>DuckStation Controller Settings</string>
   </property>
   <property name="windowIcon">
-   <iconset resource="resources/resources.qrc">
+   <iconset resource="resources/duckstation-qt.qrc">
     <normaloff>:/icons/duck.png</normaloff>:/icons/duck.png</iconset>
   </property>
   <layout class="QGridLayout" name="gridLayout">
@@ -65,9 +65,9 @@
    <item row="1" column="0" colspan="2">
     <layout class="QHBoxLayout" name="horizontalLayout_2">
      <item>
-      <layout class="QHBoxLayout" name="horizontalLayout">
+      <layout class="QHBoxLayout" name="editProfileLayout">
        <item>
-        <widget class="QLabel" name="label">
+        <widget class="QLabel" name="editProfileLabel">
          <property name="text">
           <string>Editing Profile:</string>
          </property>
@@ -106,6 +106,16 @@
          </property>
         </widget>
        </item>
+       <item>
+        <widget class="QPushButton" name="copyGlobalSettings">
+         <property name="text">
+          <string>Copy Global Settings</string>
+         </property>
+         <property name="icon">
+          <iconset theme="folder-open-line"/>
+         </property>
+        </widget>
+       </item>
        <item>
         <widget class="QPushButton" name="restoreDefaults">
          <property name="text">
@@ -130,7 +140,7 @@
   </layout>
  </widget>
  <resources>
-  <include location="resources/resources.qrc"/>
+  <include location="resources/duckstation-qt.qrc"/>
  </resources>
  <connections/>
 </ui>
diff --git a/src/duckstation-qt/gamesummarywidget.cpp b/src/duckstation-qt/gamesummarywidget.cpp
index 299e39362..aafb92ebb 100644
--- a/src/duckstation-qt/gamesummarywidget.cpp
+++ b/src/duckstation-qt/gamesummarywidget.cpp
@@ -11,6 +11,7 @@
 #include "core/game_database.h"
 #include "core/game_list.h"
 
+#include "common/error.h"
 #include "common/string_util.h"
 
 #include "fmt/format.h"
@@ -54,6 +55,7 @@ GameSummaryWidget::GameSummaryWidget(const std::string& path, const std::string&
 
   connect(m_ui.compatibilityComments, &QToolButton::clicked, this, &GameSummaryWidget::onCompatibilityCommentsClicked);
   connect(m_ui.inputProfile, &QComboBox::currentIndexChanged, this, &GameSummaryWidget::onInputProfileChanged);
+  connect(m_ui.editInputProfile, &QAbstractButton::clicked, this, &GameSummaryWidget::onEditInputProfileClicked);
   connect(m_ui.computeHashes, &QAbstractButton::clicked, this, &GameSummaryWidget::onComputeHashClicked);
 
   connect(m_ui.title, &QLineEdit::editingFinished, this, [this]() {
@@ -159,15 +161,27 @@ void GameSummaryWidget::populateUi(const std::string& path, const std::string& s
 
   m_ui.compatibilityComments->setVisible(!m_compatibility_comments.isEmpty());
 
-  m_ui.inputProfile->addItem(QIcon::fromTheme(QStringLiteral("controller-digital-line")), tr("Use Global Settings"));
+  m_ui.inputProfile->addItem(QIcon::fromTheme(QStringLiteral("global-line")), tr("Use Global Settings"));
+  m_ui.inputProfile->addItem(QIcon::fromTheme(QStringLiteral("controller-digital-line")),
+                             tr("Game Specific Configuration"));
   for (const std::string& name : InputManager::GetInputProfileNames())
     m_ui.inputProfile->addItem(QString::fromStdString(name));
 
-  std::optional<std::string> profile(m_dialog->getStringValue("ControllerPorts", "InputProfileName", std::nullopt));
-  if (profile.has_value())
-    m_ui.inputProfile->setCurrentIndex(m_ui.inputProfile->findText(QString::fromStdString(profile.value())));
+  if (m_dialog->getBoolValue("ControllerPorts", "UseGameSettingsForController", std::nullopt).value_or(false))
+  {
+    m_ui.inputProfile->setCurrentIndex(1);
+  }
+  else if (const std::optional<std::string> profile_name =
+             m_dialog->getStringValue("ControllerPorts", "InputProfileName", std::nullopt);
+           profile_name.has_value() && !profile_name->empty())
+  {
+    m_ui.inputProfile->setCurrentIndex(m_ui.inputProfile->findText(QString::fromStdString(profile_name.value())));
+  }
   else
+  {
     m_ui.inputProfile->setCurrentIndex(0);
+  }
+  m_ui.editInputProfile->setEnabled(m_ui.inputProfile->currentIndex() >= 1);
 
   populateCustomAttributes();
   populateTracksInfo();
@@ -221,6 +235,21 @@ void GameSummaryWidget::setCustomRegion(int region)
   g_main_window->refreshGameListModel();
 }
 
+void GameSummaryWidget::setRevisionText(const QString& text)
+{
+  if (text.isEmpty())
+    return;
+
+  if (m_ui.verifySpacer)
+  {
+    m_ui.verifyLayout->removeItem(m_ui.verifySpacer);
+    delete m_ui.verifySpacer;
+    m_ui.verifySpacer = nullptr;
+  }
+  m_ui.revision->setText(text);
+  m_ui.revision->setVisible(true);
+}
+
 static QString MSFTotString(const CDImage::Position& position)
 {
   return QStringLiteral("%1:%2:%3 (LBA %4)")
@@ -242,6 +271,11 @@ void GameSummaryWidget::populateTracksInfo()
   if (!image)
     return;
 
+  setRevisionText(tr("%1 tracks covering %2 MB (%3 MB on disk)")
+                    .arg(image->GetTrackCount())
+                    .arg(((image->GetLBACount() * CDImage::RAW_SECTOR_SIZE) + 1048575) / 1048576)
+                    .arg((image->GetSizeOnDisk() + 1048575) / 1048576));
+
   const u32 num_tracks = image->GetTrackCount();
   for (u32 track = 1; track <= num_tracks; track++)
   {
@@ -288,10 +322,61 @@ void GameSummaryWidget::onCompatibilityCommentsClicked()
 
 void GameSummaryWidget::onInputProfileChanged(int index)
 {
+
+  SettingsInterface* sif = m_dialog->getSettingsInterface();
   if (index == 0)
-    m_dialog->setStringSettingValue("ControllerPorts", "InputProfileName", std::nullopt);
+  {
+    // Use global settings.
+    sif->DeleteValue("ControllerPorts", "InputProfileName");
+    sif->DeleteValue("ControllerPorts", "UseGameSettingsForController");
+  }
+  else if (index == 1)
+  {
+    // Per-game configuration.
+    sif->DeleteValue("ControllerPorts", "InputProfileName");
+    sif->SetBoolValue("ControllerPorts", "UseGameSettingsForController", true);
+
+    if (!sif->GetBoolValue("ControllerPorts", "GameSettingsInitialized", false))
+    {
+      sif->SetBoolValue("ControllerPorts", "GameSettingsInitialized", true);
+
+      {
+        const auto lock = Host::GetSettingsLock();
+        SettingsInterface* base_sif = Host::Internal::GetBaseSettingsLayer();
+        InputManager::CopyConfiguration(sif, *base_sif, true, true, false);
+
+        QWidget* dlg_parent = QtUtils::GetRootWidget(this);
+        QMessageBox::information(dlg_parent, dlg_parent->windowTitle(),
+                                 tr("Per-game controller configuration initialized with global settings."));
+      }
+    }
+  }
   else
-    m_dialog->setStringSettingValue("ControllerPorts", "InputProfileName", m_ui.inputProfile->itemText(index).toUtf8());
+  {
+    // Input profile.
+    sif->SetStringValue("ControllerPorts", "InputProfileName", m_ui.inputProfile->itemText(index).toUtf8());
+    sif->DeleteValue("ControllerPorts", "UseGameSettingsForController");
+  }
+
+  m_dialog->saveAndReloadGameSettings();
+  m_ui.editInputProfile->setEnabled(index > 0);
+}
+
+void GameSummaryWidget::onEditInputProfileClicked()
+{
+  if (m_dialog->getBoolValue("ControllerPorts", "UseGameSettingsForController", std::nullopt).value_or(false))
+  {
+    // Edit game configuration.
+    ControllerSettingsWindow::editControllerSettingsForGame(QtUtils::GetRootWidget(this),
+                                                            m_dialog->getSettingsInterface());
+  }
+  else if (const std::optional<std::string> profile_name =
+             m_dialog->getStringValue("ControllerPorts", "InputProfileName", std::nullopt);
+           profile_name.has_value() && !profile_name->empty())
+  {
+    // Edit input profile.
+    g_main_window->openInputProfileEditor(profile_name.value());
+  }
 }
 
 void GameSummaryWidget::onComputeHashClicked()
@@ -417,17 +502,7 @@ void GameSummaryWidget::onComputeHashClicked()
         text = mismatch_str;
     }
 
-    if (!text.isEmpty())
-    {
-      if (m_ui.verifySpacer)
-      {
-        m_ui.verifyLayout->removeItem(m_ui.verifySpacer);
-        delete m_ui.verifySpacer;
-        m_ui.verifySpacer = nullptr;
-      }
-      m_ui.revision->setText(text);
-      m_ui.revision->setVisible(true);
-    }
+    setRevisionText(text);
   }
 
   for (u8 track = 0; track < image->GetTrackCount(); track++)
diff --git a/src/duckstation-qt/gamesummarywidget.h b/src/duckstation-qt/gamesummarywidget.h
index cbc11fc25..b27526f05 100644
--- a/src/duckstation-qt/gamesummarywidget.h
+++ b/src/duckstation-qt/gamesummarywidget.h
@@ -27,6 +27,7 @@ public:
 private Q_SLOTS:
   void onCompatibilityCommentsClicked();
   void onInputProfileChanged(int index);
+  void onEditInputProfileClicked();
   void onComputeHashClicked();
 
 private:
@@ -36,6 +37,7 @@ private:
   void updateWindowTitle();
   void setCustomTitle(const std::string& text);
   void setCustomRegion(int region);
+  void setRevisionText(const QString& text);
 
   void populateTracksInfo();
 
diff --git a/src/duckstation-qt/gamesummarywidget.ui b/src/duckstation-qt/gamesummarywidget.ui
index 66734be96..c4f21e620 100644
--- a/src/duckstation-qt/gamesummarywidget.ui
+++ b/src/duckstation-qt/gamesummarywidget.ui
@@ -60,17 +60,17 @@
    </item>
    <item row="6" column="1">
     <layout class="QHBoxLayout" name="horizontalLayout_6">
-      <item>
-        <widget class="QComboBox" name="region">
-        <property name="sizePolicy">
-          <sizepolicy hsizetype="Expanding" vsizetype="Fixed">
-          <horstretch>0</horstretch>
-          <verstretch>0</verstretch>
-          </sizepolicy>
-        </property>
-        </widget>
-      </item>
-      <item>
+     <item>
+      <widget class="QComboBox" name="region">
+       <property name="sizePolicy">
+        <sizepolicy hsizetype="Expanding" vsizetype="Fixed">
+         <horstretch>0</horstretch>
+         <verstretch>0</verstretch>
+        </sizepolicy>
+       </property>
+      </widget>
+     </item>
+     <item>
       <widget class="QPushButton" name="restoreRegion">
        <property name="enabled">
         <bool>false</bool>
@@ -79,7 +79,7 @@
         <string>Restore</string>
        </property>
       </widget>
-	 </item>
+     </item>
     </layout>
    </item>
    <item row="0" column="0">
@@ -106,7 +106,7 @@
    <item row="18" column="0" colspan="2">
     <widget class="QTableWidget" name="tracks">
      <property name="editTriggers">
-      <set>QAbstractItemView::NoEditTriggers</set>
+      <set>QAbstractItemView::EditTrigger::NoEditTriggers</set>
      </property>
      <property name="cornerButtonEnabled">
       <bool>false</bool>
@@ -216,15 +216,12 @@
      </property>
     </widget>
    </item>
-   <item row="13" column="1">
-    <widget class="QComboBox" name="inputProfile"/>
-   </item>
    <item row="16" column="1">
     <layout class="QHBoxLayout" name="verifyLayout" stretch="0,1,0">
      <item>
       <spacer name="verifySpacer">
        <property name="orientation">
-        <enum>Qt::Horizontal</enum>
+        <enum>Qt::Orientation::Horizontal</enum>
        </property>
        <property name="sizeHint" stdset="0">
         <size>
@@ -306,8 +303,21 @@
         <string>Comments</string>
        </property>
        <property name="icon">
-        <iconset theme="information-line">
-         <normaloff>.</normaloff>.</iconset>
+        <iconset theme="information-line"/>
+       </property>
+      </widget>
+     </item>
+    </layout>
+   </item>
+   <item row="13" column="1">
+    <layout class="QHBoxLayout" name="horizontalLayout_2" stretch="1,0">
+     <item>
+      <widget class="QComboBox" name="inputProfile"/>
+     </item>
+     <item>
+      <widget class="QPushButton" name="editInputProfile">
+       <property name="text">
+        <string>Edit...</string>
        </property>
       </widget>
      </item>
diff --git a/src/duckstation-qt/hotkeysettingswidget.cpp b/src/duckstation-qt/hotkeysettingswidget.cpp
index 66e94606b..f71b8509a 100644
--- a/src/duckstation-qt/hotkeysettingswidget.cpp
+++ b/src/duckstation-qt/hotkeysettingswidget.cpp
@@ -73,7 +73,7 @@ void HotkeySettingsWidget::createButtons()
     QLabel* label = new QLabel(qApp->translate("Hotkeys", hotkey->display_name), m_container);
     layout->addWidget(label, target_row, 0);
 
-    InputBindingWidget* bind = new InputBindingWidget(m_container, m_dialog->getProfileSettingsInterface(),
+    InputBindingWidget* bind = new InputBindingWidget(m_container, m_dialog->getEditingSettingsInterface(),
                                                       InputBindingInfo::Type::Button, "Hotkeys", hotkey->name);
     bind->setMinimumWidth(300);
     layout->addWidget(bind, target_row, 1);
diff --git a/src/duckstation-qt/mainwindow.cpp b/src/duckstation-qt/mainwindow.cpp
index cbf255bc0..bfece5b39 100644
--- a/src/duckstation-qt/mainwindow.cpp
+++ b/src/duckstation-qt/mainwindow.cpp
@@ -2394,6 +2394,13 @@ void MainWindow::doControllerSettings(
     dlg->setCategory(category);
 }
 
+void MainWindow::openInputProfileEditor(const std::string_view name)
+{
+  ControllerSettingsWindow* dlg = getControllerSettingsWindow();
+  QtUtils::ShowOrRaiseWindow(dlg);
+  dlg->switchProfile(name);
+}
+
 void MainWindow::updateDebugMenuCPUExecutionMode()
 {
   std::optional<CPUExecutionMode> current_mode =
diff --git a/src/duckstation-qt/mainwindow.h b/src/duckstation-qt/mainwindow.h
index 36425e3da..fba4d7e36 100644
--- a/src/duckstation-qt/mainwindow.h
+++ b/src/duckstation-qt/mainwindow.h
@@ -99,6 +99,9 @@ public:
   /// Accessors for child windows.
   CheatManagerWindow* getCheatManagerWindow() const { return m_cheat_manager_window; }
 
+  /// Opens the editor for a specific input profile.
+  void openInputProfileEditor(const std::string_view name);
+
 public Q_SLOTS:
   /// Updates debug menu visibility (hides if disabled).
   void updateDebugMenuVisibility();
diff --git a/src/duckstation-qt/settingswindow.cpp b/src/duckstation-qt/settingswindow.cpp
index 443226d40..67a7eb90d 100644
--- a/src/duckstation-qt/settingswindow.cpp
+++ b/src/duckstation-qt/settingswindow.cpp
@@ -296,7 +296,7 @@ void SettingsWindow::onCopyGlobalSettingsClicked()
   {
     auto lock = Host::GetSettingsLock();
     Settings temp;
-    temp.Load(*Host::Internal::GetBaseSettingsLayer());
+    temp.Load(*Host::Internal::GetBaseSettingsLayer(), *Host::Internal::GetBaseSettingsLayer());
     temp.Save(*m_sif.get(), true);
   }
   saveAndReloadGameSettings();
diff --git a/src/duckstation-qt/settingswindow.h b/src/duckstation-qt/settingswindow.h
index 3486dacd5..d6ef46066 100644
--- a/src/duckstation-qt/settingswindow.h
+++ b/src/duckstation-qt/settingswindow.h
@@ -93,6 +93,7 @@ public:
   bool containsSettingValue(const char* section, const char* key) const;
   void removeSettingValue(const char* section, const char* key);
   void saveAndReloadGameSettings();
+  void reloadGameSettingsFromIni();
 
   bool hasGameTrait(GameDatabase::Trait trait);
 
diff --git a/src/util/ini_settings_interface.cpp b/src/util/ini_settings_interface.cpp
index ab9ddabbd..6e3b1c8ac 100644
--- a/src/util/ini_settings_interface.cpp
+++ b/src/util/ini_settings_interface.cpp
@@ -74,16 +74,23 @@ INISettingsInterface::~INISettingsInterface()
     Save();
 }
 
-bool INISettingsInterface::Load()
+bool INISettingsInterface::Load(Error* error /* = nullptr */)
 {
   if (m_filename.empty())
+  {
+    Error::SetStringView(error, "Filename is not set.");
     return false;
+  }
 
   std::unique_lock lock(s_ini_load_save_mutex);
   SI_Error err = SI_FAIL;
-  auto fp = FileSystem::OpenManagedCFile(m_filename.c_str(), "rb");
+  auto fp = FileSystem::OpenManagedCFile(m_filename.c_str(), "rb", error);
   if (fp)
+  {
     err = m_ini.LoadFile(fp.get());
+    if (err != SI_OK)
+      Error::SetStringFmt(error, "INI LoadFile() failed: {}", static_cast<int>(err));
+  }
 
   return (err == SI_OK);
 }
diff --git a/src/util/ini_settings_interface.h b/src/util/ini_settings_interface.h
index eba6f13dc..8e1c19423 100644
--- a/src/util/ini_settings_interface.h
+++ b/src/util/ini_settings_interface.h
@@ -18,7 +18,7 @@ public:
 
   const std::string& GetFileName() const { return m_filename; }
 
-  bool Load();
+  bool Load(Error* error = nullptr);
   bool Save(Error* error = nullptr) override;
 
   void Clear() override;
diff --git a/src/util/input_manager.cpp b/src/util/input_manager.cpp
index 542ca4561..8d7cf1fc4 100644
--- a/src/util/input_manager.cpp
+++ b/src/util/input_manager.cpp
@@ -1809,8 +1809,7 @@ bool InputManager::DoEventHook(InputBindingKey key, float value)
 // Binding Updater
 // ------------------------------------------------------------------------
 
-void InputManager::ReloadBindings(SettingsInterface& si, SettingsInterface& binding_si,
-                                  SettingsInterface& hotkey_binding_si)
+void InputManager::ReloadBindings(SettingsInterface& binding_si, SettingsInterface& hotkey_binding_si)
 {
   PauseVibration();
 
@@ -1843,8 +1842,8 @@ void InputManager::ReloadBindings(SettingsInterface& si, SettingsInterface& bind
     // From lilypad: 1 mouse pixel = 1/8th way down.
     const float default_scale = (axis <= static_cast<u32>(InputPointerAxis::Y)) ? 8.0f : 1.0f;
     s_pointer_axis_scale[axis] =
-      1.0f / std::max(si.GetFloatValue("Pad", fmt::format("Pointer{}Scale", s_pointer_axis_names[axis]).c_str(),
-                                       default_scale),
+      1.0f / std::max(binding_si.GetFloatValue("Pad", fmt::format("Pointer{}Scale", s_pointer_axis_names[axis]).c_str(),
+                                               default_scale),
                       1.0f);
   }
 
diff --git a/src/util/input_manager.h b/src/util/input_manager.h
index dfba363c1..b878645ae 100644
--- a/src/util/input_manager.h
+++ b/src/util/input_manager.h
@@ -253,7 +253,7 @@ GenericInputBindingMapping GetGenericBindingMapping(std::string_view device);
 bool IsInputSourceEnabled(SettingsInterface& si, InputSourceType type);
 
 /// Re-parses the config and registers all hotkey and pad bindings.
-void ReloadBindings(SettingsInterface& si, SettingsInterface& binding_si, SettingsInterface& hotkey_binding_si);
+void ReloadBindings(SettingsInterface& si, SettingsInterface& hotkey_binding_si);
 
 /// Re-parses the sources part of the config and initializes any backends.
 void ReloadSources(SettingsInterface& si, std::unique_lock<std::mutex>& settings_lock);