diff --git a/CMakeLists.txt b/CMakeLists.txt
index 7eaa3b4fb..27832e706 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -84,6 +84,9 @@ if(MSVC)
   string(REPLACE "/GR" "" CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS}")
 
   set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} /D_HAS_EXCEPTIONS=0 /permissive-")
+  if(COMPILER_CLANG_CL)
+    set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} /clang:-fno-rtti")
+  endif()
 else()
   set(CMAKE_CXX_FLAGS "${CMAKE_CXX_FLAGS} -fno-exceptions -fno-rtti")
 endif()
diff --git a/dep/msvc/vsprops/Base.props b/dep/msvc/vsprops/Base.props
index fa05c047e..798d758c5 100644
--- a/dep/msvc/vsprops/Base.props
+++ b/dep/msvc/vsprops/Base.props
@@ -35,6 +35,8 @@
       <AdditionalOptions Condition="$(Configuration.Contains(Clang)) And $(Configuration.Contains(ReleaseLTCG))"> -flto=thin %(AdditionalOptions)</AdditionalOptions>
       <DisableSpecificWarnings Condition="!$(Configuration.Contains(Clang))">4324;%(DisableSpecificWarnings)</DisableSpecificWarnings>
       <ExceptionHandling>false</ExceptionHandling>
+      <RuntimeTypeInfo>false</RuntimeTypeInfo>
+      <AdditionalOptions Condition="$(Configuration.Contains(Clang))">/clang:-fno-rtti %(AdditionalOptions)</AdditionalOptions>
     </ClCompile>
     <Link>
       <GenerateDebugInformation>true</GenerateDebugInformation>
diff --git a/src/duckstation-qt/duckstation-qt.vcxproj b/src/duckstation-qt/duckstation-qt.vcxproj
index af91a4dd4..2408fe46e 100644
--- a/src/duckstation-qt/duckstation-qt.vcxproj
+++ b/src/duckstation-qt/duckstation-qt.vcxproj
@@ -398,6 +398,10 @@
       <PreprocessorDefinitions>QT_NO_EXCEPTIONS=1;%(PreprocessorDefinitions)</PreprocessorDefinitions>
       <DisableSpecificWarnings>4127;%(DisableSpecificWarnings)</DisableSpecificWarnings>
       <AdditionalIncludeDirectories>%(AdditionalIncludeDirectories);$(SolutionDir)dep\minizip\include</AdditionalIncludeDirectories>
+
+      <!-- Qt relies on RTTI for assertions in Debug builds. -->
+      <RuntimeTypeInfo Condition="$(Configuration.Contains(Debug))">true</RuntimeTypeInfo>
+      <AdditionalOptions Condition="$(Configuration.Contains(Clang)) And $(Configuration.Contains(Debug))">%(AdditionalOptions) /clang:-frtti</AdditionalOptions>
     </ClCompile>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="$(Configuration.Contains(Clang))">