diff --git a/src/core/bus.cpp b/src/core/bus.cpp
index 5b5b95c6e..2bcb8362a 100644
--- a/src/core/bus.cpp
+++ b/src/core/bus.cpp
@@ -1,6 +1,7 @@
 #include "bus.h"
 #include "YBaseLib/ByteStream.h"
 #include "YBaseLib/Log.h"
+#include "YBaseLib/MD5Digest.h"
 #include "YBaseLib/String.h"
 #include "cdrom.h"
 #include "common/state_wrapper.h"
@@ -31,12 +32,9 @@ Bus::Bus() = default;
 
 Bus::~Bus() = default;
 
-bool Bus::Initialize(CPU::Core* cpu, DMA* dma, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom,
+void Bus::Initialize(CPU::Core* cpu, DMA* dma, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom,
                      Pad* pad, Timers* timers, SPU* spu, MDEC* mdec)
 {
-  if (!LoadBIOS())
-    return false;
-
   m_cpu = cpu;
   m_dma = dma;
   m_interrupt_controller = interrupt_controller;
@@ -46,7 +44,6 @@ bool Bus::Initialize(CPU::Core* cpu, DMA* dma, InterruptController* interrupt_co
   m_timers = timers;
   m_spu = spu;
   m_mdec = mdec;
-  return true;
 }
 
 void Bus::Reset()
@@ -187,16 +184,26 @@ void Bus::PatchBIOS(u32 address, u32 value, u32 mask /*= UINT32_C(0xFFFFFFFF)*/)
                  old_disasm.GetCharArray(), new_value, new_disasm.GetCharArray());
 }
 
+void Bus::GetBIOSHash(u8 hash[16])
+{
+  MD5Digest digest;
+  digest.Update(m_bios.data(), static_cast<u32>(m_bios.size()));
+  digest.Final(hash);
+}
+
 void Bus::SetExpansionROM(std::vector<u8> data)
 {
   m_exp1_rom = std::move(data);
 }
 
-bool Bus::LoadBIOS()
+bool Bus::LoadBIOS(const char* filename)
 {
-  std::FILE* fp = std::fopen("SCPH1001.BIN", "rb");
+  std::FILE* fp = std::fopen(filename, "rb");
   if (!fp)
+  {
+    Log_ErrorPrintf("Failed to open BIOS image '%s'", filename);
     return false;
+  }
 
   std::fseek(fp, 0, SEEK_END);
   const u32 size = static_cast<u32>(std::ftell(fp));
@@ -217,13 +224,6 @@ bool Bus::LoadBIOS()
   }
 
   std::fclose(fp);
-
-#if 1
-  // Patch to enable TTY.
-  PatchBIOS(BIOS_BASE + 0x6F0C, 0x24010001);
-  PatchBIOS(BIOS_BASE + 0x6F14, 0xAF81A9C0);
-#endif
-
   return true;
 }
 
diff --git a/src/core/bus.h b/src/core/bus.h
index 9d4a28123..75138b69f 100644
--- a/src/core/bus.h
+++ b/src/core/bus.h
@@ -27,11 +27,15 @@ public:
   Bus();
   ~Bus();
 
-  bool Initialize(CPU::Core* cpu, DMA* dma, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom, Pad* pad,
+  void Initialize(CPU::Core* cpu, DMA* dma, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom, Pad* pad,
                   Timers* timers, SPU* spu, MDEC* mdec);
   void Reset();
   bool DoState(StateWrapper& sw);
 
+  bool LoadBIOS(const char* filename);
+  void PatchBIOS(u32 address, u32 value, u32 mask = UINT32_C(0xFFFFFFFF));
+  void GetBIOSHash(u8 hash[16]);
+
   bool ReadByte(PhysicalMemoryAddress address, u8* value);
   bool ReadHalfWord(PhysicalMemoryAddress address, u16* value);
   bool ReadWord(PhysicalMemoryAddress address, u32* value);
@@ -46,7 +50,6 @@ public:
   TickCount ReadWords(PhysicalMemoryAddress address, u32* words, u32 word_count);
   TickCount WriteWords(PhysicalMemoryAddress address, const u32* words, u32 word_count);
 
-  void PatchBIOS(u32 address, u32 value, u32 mask = UINT32_C(0xFFFFFFFF));
   void SetExpansionROM(std::vector<u8> data);
 
   // changing interfaces
@@ -154,8 +157,6 @@ private:
     };
   };
 
-  bool LoadBIOS();
-
   static std::tuple<TickCount, TickCount, TickCount> CalculateMemoryTiming(MEMDELAY mem_delay, COMDELAY common_delay);
   void RecalculateMemoryTimings();
 
diff --git a/src/core/cdrom.cpp b/src/core/cdrom.cpp
index e2cae166d..b836a1667 100644
--- a/src/core/cdrom.cpp
+++ b/src/core/cdrom.cpp
@@ -16,13 +16,12 @@ CDROM::CDROM()
 
 CDROM::~CDROM() = default;
 
-bool CDROM::Initialize(System* system, DMA* dma, InterruptController* interrupt_controller, SPU* spu)
+void CDROM::Initialize(System* system, DMA* dma, InterruptController* interrupt_controller, SPU* spu)
 {
   m_system = system;
   m_dma = dma;
   m_interrupt_controller = interrupt_controller;
   m_spu = spu;
-  return true;
 }
 
 void CDROM::Reset()
diff --git a/src/core/cdrom.h b/src/core/cdrom.h
index 492da5f59..92caf21a9 100644
--- a/src/core/cdrom.h
+++ b/src/core/cdrom.h
@@ -22,7 +22,7 @@ public:
   CDROM();
   ~CDROM();
 
-  bool Initialize(System* system, DMA* dma, InterruptController* interrupt_controller, SPU* spu);
+  void Initialize(System* system, DMA* dma, InterruptController* interrupt_controller, SPU* spu);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/cpu_core.cpp b/src/core/cpu_core.cpp
index 20ed2e900..ad4d8e2a3 100644
--- a/src/core/cpu_core.cpp
+++ b/src/core/cpu_core.cpp
@@ -38,7 +38,7 @@ Core::Core() = default;
 
 Core::~Core() = default;
 
-bool Core::Initialize(Bus* bus)
+void Core::Initialize(Bus* bus)
 {
   m_bus = bus;
 
@@ -46,8 +46,6 @@ bool Core::Initialize(Bus* bus)
   m_cop0_regs.PRID = UINT32_C(0x00000002);
 
   m_cop2.Initialize();
-
-  return true;
 }
 
 void Core::Reset()
diff --git a/src/core/cpu_core.h b/src/core/cpu_core.h
index 924d46bf3..cc8080419 100644
--- a/src/core/cpu_core.h
+++ b/src/core/cpu_core.h
@@ -24,7 +24,7 @@ public:
   Core();
   ~Core();
 
-  bool Initialize(Bus* bus);
+  void Initialize(Bus* bus);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/dma.cpp b/src/core/dma.cpp
index 8a2d7fb56..bcec2ccff 100644
--- a/src/core/dma.cpp
+++ b/src/core/dma.cpp
@@ -14,7 +14,7 @@ DMA::DMA() = default;
 
 DMA::~DMA() = default;
 
-bool DMA::Initialize(System* system, Bus* bus, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom,
+void DMA::Initialize(System* system, Bus* bus, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom,
                      SPU* spu, MDEC* mdec)
 {
   m_system = system;
@@ -25,7 +25,6 @@ bool DMA::Initialize(System* system, Bus* bus, InterruptController* interrupt_co
   m_spu = spu;
   m_mdec = mdec;
   m_transfer_buffer.resize(32);
-  return true;
 }
 
 void DMA::Reset()
diff --git a/src/core/dma.h b/src/core/dma.h
index 6fa735bfe..310cec044 100644
--- a/src/core/dma.h
+++ b/src/core/dma.h
@@ -35,7 +35,7 @@ public:
   DMA();
   ~DMA();
 
-  bool Initialize(System* system, Bus* bus, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom, SPU* spu,
+  void Initialize(System* system, Bus* bus, InterruptController* interrupt_controller, GPU* gpu, CDROM* cdrom, SPU* spu,
                   MDEC* mdec);
   void Reset();
   bool DoState(StateWrapper& sw);
diff --git a/src/core/interrupt_controller.cpp b/src/core/interrupt_controller.cpp
index 4b5bc47d9..7b14753c1 100644
--- a/src/core/interrupt_controller.cpp
+++ b/src/core/interrupt_controller.cpp
@@ -8,10 +8,9 @@ InterruptController::InterruptController() = default;
 
 InterruptController::~InterruptController() = default;
 
-bool InterruptController::Initialize(CPU::Core* cpu)
+void InterruptController::Initialize(CPU::Core* cpu)
 {
   m_cpu = cpu;
-  return true;
 }
 
 void InterruptController::Reset()
diff --git a/src/core/interrupt_controller.h b/src/core/interrupt_controller.h
index d6a4ec6c8..ab6cbd4d3 100644
--- a/src/core/interrupt_controller.h
+++ b/src/core/interrupt_controller.h
@@ -32,7 +32,7 @@ public:
   InterruptController();
   ~InterruptController();
 
-  bool Initialize(CPU::Core* cpu);
+  void Initialize(CPU::Core* cpu);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/mdec.cpp b/src/core/mdec.cpp
index 15d16ed8b..81c641879 100644
--- a/src/core/mdec.cpp
+++ b/src/core/mdec.cpp
@@ -11,11 +11,10 @@ MDEC::MDEC() = default;
 
 MDEC::~MDEC() = default;
 
-bool MDEC::Initialize(System* system, DMA* dma)
+void MDEC::Initialize(System* system, DMA* dma)
 {
   m_system = system;
   m_dma = dma;
-  return true;
 }
 
 void MDEC::Reset()
diff --git a/src/core/mdec.h b/src/core/mdec.h
index c01510b40..c6cb73e68 100644
--- a/src/core/mdec.h
+++ b/src/core/mdec.h
@@ -15,7 +15,7 @@ public:
   MDEC();
   ~MDEC();
 
-  bool Initialize(System* system, DMA* dma);
+  void Initialize(System* system, DMA* dma);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/pad.cpp b/src/core/pad.cpp
index eac92a26f..2149610fb 100644
--- a/src/core/pad.cpp
+++ b/src/core/pad.cpp
@@ -12,11 +12,10 @@ Pad::Pad() = default;
 
 Pad::~Pad() = default;
 
-bool Pad::Initialize(System* system, InterruptController* interrupt_controller)
+void Pad::Initialize(System* system, InterruptController* interrupt_controller)
 {
   m_system = system;
   m_interrupt_controller = interrupt_controller;
-  return true;
 }
 
 void Pad::Reset()
diff --git a/src/core/pad.h b/src/core/pad.h
index 36cc0050b..1b75e7925 100644
--- a/src/core/pad.h
+++ b/src/core/pad.h
@@ -18,7 +18,7 @@ public:
   Pad();
   ~Pad();
 
-  bool Initialize(System* system, InterruptController* interrupt_controller);
+  void Initialize(System* system, InterruptController* interrupt_controller);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/spu.cpp b/src/core/spu.cpp
index cb79fa411..5437cc994 100644
--- a/src/core/spu.cpp
+++ b/src/core/spu.cpp
@@ -19,13 +19,12 @@ SPU::SPU() = default;
 
 SPU::~SPU() = default;
 
-bool SPU::Initialize(System* system, DMA* dma, InterruptController* interrupt_controller)
+void SPU::Initialize(System* system, DMA* dma, InterruptController* interrupt_controller)
 {
   m_audio_stream = system->GetHostInterface()->GetAudioStream();
   m_system = system;
   m_dma = dma;
   m_interrupt_controller = interrupt_controller;
-  return true;
 }
 
 void SPU::Reset()
diff --git a/src/core/spu.h b/src/core/spu.h
index bfe22b42e..d8e4f96db 100644
--- a/src/core/spu.h
+++ b/src/core/spu.h
@@ -17,7 +17,7 @@ public:
   SPU();
   ~SPU();
 
-  bool Initialize(System* system, DMA* dma, InterruptController* interrupt_controller);
+  void Initialize(System* system, DMA* dma, InterruptController* interrupt_controller);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/core/system.cpp b/src/core/system.cpp
index 73ae85ca0..1ba481f4f 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -19,8 +19,16 @@
 #include <imgui.h>
 Log_SetChannel(System);
 
-System::System(HostInterface* host_interface)
-  : m_host_interface(host_interface)
+namespace BIOSHashes {
+static constexpr char SCPH_1000[] = "239665b1a3dade1b5a52c06338011044";
+static constexpr char SCPH_1001[] = "924e392ed05558ffdb115408c263dccf";
+static constexpr char SCPH_1002[] = "54847e693405ffeb0359c6287434cbef";
+static constexpr char SCPH_5500[] = "8dd7d5296a650fac7319bce665a6a53c";
+static constexpr char SCPH_5501[] = "490f666e1afb15b7362b406ed1cea246";
+static constexpr char SCPH_5502[] = "32736f17079d0b2b7024407c39bd3050";
+} // namespace BIOSHashes
+
+System::System(HostInterface* host_interface) : m_host_interface(host_interface)
 {
   m_cpu = std::make_unique<CPU::Core>();
   m_bus = std::make_unique<Bus>();
@@ -64,44 +72,28 @@ bool System::RecreateGPU()
 
 bool System::Initialize()
 {
-  if (!m_cpu->Initialize(m_bus.get()))
-    return false;
+  m_cpu->Initialize(m_bus.get());
+  m_bus->Initialize(m_cpu.get(), m_dma.get(), m_interrupt_controller.get(), m_gpu.get(), m_cdrom.get(), m_pad.get(),
+                    m_timers.get(), m_spu.get(), m_mdec.get());
 
-  if (!m_bus->Initialize(m_cpu.get(), m_dma.get(), m_interrupt_controller.get(), m_gpu.get(), m_cdrom.get(),
-                         m_pad.get(), m_timers.get(), m_spu.get(), m_mdec.get()))
-  {
-    return false;
-  }
+  m_dma->Initialize(this, m_bus.get(), m_interrupt_controller.get(), m_gpu.get(), m_cdrom.get(), m_spu.get(),
+                    m_mdec.get());
 
-  if (!m_dma->Initialize(this, m_bus.get(), m_interrupt_controller.get(), m_gpu.get(), m_cdrom.get(), m_spu.get(),
-                         m_mdec.get()))
-  {
-    return false;
-  }
+  m_interrupt_controller->Initialize(m_cpu.get());
 
-  if (!m_interrupt_controller->Initialize(m_cpu.get()))
-    return false;
+  m_cdrom->Initialize(this, m_dma.get(), m_interrupt_controller.get(), m_spu.get());
+  m_pad->Initialize(this, m_interrupt_controller.get());
+  m_timers->Initialize(this, m_interrupt_controller.get());
+  m_spu->Initialize(this, m_dma.get(), m_interrupt_controller.get());
+  m_mdec->Initialize(this, m_dma.get());
 
   if (!CreateGPU())
     return false;
 
-  if (!m_cdrom->Initialize(this, m_dma.get(), m_interrupt_controller.get(), m_spu.get()))
-    return false;
-
-  if (!m_pad->Initialize(this, m_interrupt_controller.get()))
-    return false;
-
-  if (!m_timers->Initialize(this, m_interrupt_controller.get()))
-    return false;
-
-  if (!m_spu->Initialize(this, m_dma.get(), m_interrupt_controller.get()))
-    return false;
-
-  if (!m_mdec->Initialize(this, m_dma.get()))
+  if (!LoadBIOS())
     return false;
 
   UpdateMemoryCards();
-
   return true;
 }
 
@@ -144,6 +136,38 @@ bool System::CreateGPU()
   return true;
 }
 
+bool System::LoadBIOS()
+{
+  if (!m_bus->LoadBIOS(GetSettings().bios_path.c_str()))
+    return false;
+
+  // apply patches
+  u8 bios_hash[16];
+  m_bus->GetBIOSHash(bios_hash);
+  SmallString bios_hash_string;
+  bios_hash_string.Format("%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x%02x", bios_hash[0],
+                          bios_hash[1], bios_hash[2], bios_hash[3], bios_hash[4], bios_hash[5], bios_hash[6],
+                          bios_hash[7], bios_hash[8], bios_hash[9], bios_hash[10], bios_hash[11], bios_hash[12],
+                          bios_hash[13], bios_hash[14], bios_hash[15]);
+  Log_InfoPrintf("BIOS hash: %s", bios_hash_string.GetCharArray());
+
+  if (bios_hash_string == BIOSHashes::SCPH_1000 || bios_hash_string == BIOSHashes::SCPH_1001 ||
+      bios_hash_string == BIOSHashes::SCPH_1002 || bios_hash_string == BIOSHashes::SCPH_5500 ||
+      bios_hash_string == BIOSHashes::SCPH_5501 || bios_hash_string == BIOSHashes::SCPH_5502)
+  {
+    // Patch to enable TTY.
+    Log_InfoPrintf("Patching BIOS to enable TTY/printf");
+    m_bus->PatchBIOS(0x1FC06F0C, 0x24010001);
+    m_bus->PatchBIOS(0x1FC06F14, 0xAF81A9C0);
+  }
+  else
+  {
+    Log_WarningPrintf("Unknown BIOS version, not patching TTY/printf");
+  }
+
+  return true;
+}
+
 bool System::DoState(StateWrapper& sw)
 {
   if (!sw.DoMarker("System"))
diff --git a/src/core/system.h b/src/core/system.h
index 760bc7573..e1cd33277 100644
--- a/src/core/system.h
+++ b/src/core/system.h
@@ -78,6 +78,7 @@ public:
 private:
   bool DoState(StateWrapper& sw);
   bool CreateGPU();
+  bool LoadBIOS();
 
   HostInterface* m_host_interface;
   std::unique_ptr<CPU::Core> m_cpu;
diff --git a/src/core/timers.cpp b/src/core/timers.cpp
index 30ab6cfbf..8dfde9f19 100644
--- a/src/core/timers.cpp
+++ b/src/core/timers.cpp
@@ -10,11 +10,10 @@ Timers::Timers() = default;
 
 Timers::~Timers() = default;
 
-bool Timers::Initialize(System* system, InterruptController* interrupt_controller)
+void Timers::Initialize(System* system, InterruptController* interrupt_controller)
 {
   m_system = system;
   m_interrupt_controller = interrupt_controller;
-  return true;
 }
 
 void Timers::Reset()
diff --git a/src/core/timers.h b/src/core/timers.h
index df6fb1543..1d55c6778 100644
--- a/src/core/timers.h
+++ b/src/core/timers.h
@@ -14,7 +14,7 @@ public:
   Timers();
   ~Timers();
 
-  bool Initialize(System* system, InterruptController* interrupt_controller);
+  void Initialize(System* system, InterruptController* interrupt_controller);
   void Reset();
   bool DoState(StateWrapper& sw);
 
diff --git a/src/duckstation/sdl_host_interface.cpp b/src/duckstation/sdl_host_interface.cpp
index 1a521a2b1..ee2b57401 100644
--- a/src/duckstation/sdl_host_interface.cpp
+++ b/src/duckstation/sdl_host_interface.cpp
@@ -903,7 +903,7 @@ void SDLHostInterface::DrawSettingsWindow()
 
       ImGui::Text("BIOS Path:");
       ImGui::SameLine(indent);
-      DrawFileChooser("##bios_path", &m_settings.bios_path);
+      settings_changed |= DrawFileChooser("##bios_path", &m_settings.bios_path);
 
       ImGui::Checkbox("Enable Speed Limiter", &m_settings.speed_limiter_enabled);
 
@@ -1029,9 +1029,8 @@ void SDLHostInterface::DrawSettingsWindow()
   ImGui::End();
 
   if (settings_changed)
-  {
-    // TODO: Save to file
-  }
+    SaveSettings();
+
   if (gpu_settings_changed && m_system)
     m_system->GetGPU()->UpdateSettings();
 }