diff --git a/scripts/run_regression_tests.py b/scripts/run_regression_tests.py
index 657c73f40..9805173c0 100644
--- a/scripts/run_regression_tests.py
+++ b/scripts/run_regression_tests.py
@@ -6,13 +6,12 @@ import subprocess
 import multiprocessing
 from functools import partial
 
-def is_game_path(path):
-    idx = path.rfind('.')
-    if idx < 0:
-        return False
-
-    extension = path[idx + 1:].strip().lower()
-    return extension in ["cue", "chd"]
+def is_game_path(path:str):
+    lpath = path.lower()
+    for extension in ["cue", "chd", "psxgpu", "psxgpu.zst", "psxgpu.xz"]:
+        if path.endswith(extension):
+            return True
+    return False
 
 
 def run_regression_test(runner, destdir, dump_interval, frames, renderer, cargs, gamepath):
@@ -31,8 +30,10 @@ def run_regression_test(runner, destdir, dump_interval, frames, renderer, cargs,
     return os.path.basename(gamepath)
 
 
-def run_regression_tests(runner, gamedir, destdir, dump_interval, frames, parallel, renderer, cargs):
-    paths = glob.glob(gamedir + "/*.*", recursive=True)
+def run_regression_tests(runner, gamedirs, destdir, dump_interval, frames, parallel, renderer, cargs):
+    paths = []
+    for gamedir in gamedirs:
+        paths += glob.glob(os.path.realpath(gamedir) + "/*.*", recursive=True)
     gamepaths = list(filter(is_game_path, paths))
 
     try:
@@ -64,7 +65,7 @@ def run_regression_tests(runner, gamedir, destdir, dump_interval, frames, parall
 if __name__ == "__main__":
     parser = argparse.ArgumentParser(description="Generate frame dump images for regression tests")
     parser.add_argument("-runner", action="store", required=True, help="Path to DuckStation regression test runner")
-    parser.add_argument("-gamedir", action="store", required=True, help="Directory containing game images")
+    parser.add_argument("-gamedir", action="append", required=True, help="Directory containing game images")
     parser.add_argument("-destdir", action="store", required=True, help="Base directory to dump frames to")
     parser.add_argument("-dumpinterval", action="store", type=int, default=600, help="Interval to dump frames at")
     parser.add_argument("-frames", action="store", type=int, default=36000, help="Number of frames to run")
@@ -86,7 +87,7 @@ if __name__ == "__main__":
     if (args.cpu is not None):
         cargs += ["-cpu", args.cpu]
 
-    if not run_regression_tests(args.runner, os.path.realpath(args.gamedir), os.path.realpath(args.destdir), args.dumpinterval, args.frames, args.parallel, args.renderer, cargs):
+    if not run_regression_tests(args.runner, args.gamedir, os.path.realpath(args.destdir), args.dumpinterval, args.frames, args.parallel, args.renderer, cargs):
         sys.exit(1)
     else:
         sys.exit(0)
diff --git a/src/core/gpu_dump.h b/src/core/gpu_dump.h
index 3afa50aca..dfb26b5a1 100644
--- a/src/core/gpu_dump.h
+++ b/src/core/gpu_dump.h
@@ -106,6 +106,7 @@ public:
   ALWAYS_INLINE const std::string& GetPath() const { return m_path; }
   ALWAYS_INLINE const std::string& GetSerial() const { return m_serial; }
   ALWAYS_INLINE ConsoleRegion GetRegion() const { return m_region; }
+  ALWAYS_INLINE size_t GetFrameCount() const { return m_frame_offsets.size(); }
 
   static std::unique_ptr<Player> Open(std::string path, Error* error);
 
diff --git a/src/core/system.cpp b/src/core/system.cpp
index ed2a30403..e1cc4a0cf 100644
--- a/src/core/system.cpp
+++ b/src/core/system.cpp
@@ -622,6 +622,11 @@ bool System::IsReplayingGPUDump()
   return static_cast<bool>(s_state.gpu_dump_player);
 }
 
+size_t System::GetGPUDumpFrameCount()
+{
+  return s_state.gpu_dump_player ? s_state.gpu_dump_player->GetFrameCount() : 0;
+}
+
 bool System::IsStartupCancelled()
 {
   return s_state.startup_cancelled.load(std::memory_order_acquire);
diff --git a/src/core/system.h b/src/core/system.h
index 2a45403c0..50e9e31e0 100644
--- a/src/core/system.h
+++ b/src/core/system.h
@@ -172,6 +172,7 @@ bool IsValid();
 bool IsValidOrInitializing();
 bool IsExecuting();
 bool IsReplayingGPUDump();
+size_t GetGPUDumpFrameCount();
 
 bool IsStartupCancelled();
 void CancelPendingStartup();
diff --git a/src/duckstation-regtest/regtest_host.cpp b/src/duckstation-regtest/regtest_host.cpp
index cecc02e65..02c0feb6a 100644
--- a/src/duckstation-regtest/regtest_host.cpp
+++ b/src/duckstation-regtest/regtest_host.cpp
@@ -726,14 +726,6 @@ bool RegTestHost::ParseCommandLineParameters(int argc, char* argv[], std::option
 
 bool RegTestHost::SetNewDataRoot(const std::string& filename)
 {
-  Error error;
-  std::unique_ptr<CDImage> image = CDImage::Open(filename.c_str(), false, &error);
-  if (!image)
-  {
-    ERROR_LOG("Failed to open CD image '{}' to set data root: {}", Path::GetFileName(filename), error.GetDescription());
-    return false;
-  }
-
   if (!s_dump_base_directory.empty())
   {
     std::string game_subdir = Path::SanitizeFileName(Path::GetFileTitle(filename));
@@ -808,6 +800,13 @@ int main(int argc, char* argv[])
     goto cleanup;
   }
 
+  if (System::IsReplayingGPUDump() && !s_dump_base_directory.empty())
+  {
+    INFO_LOG("Replaying GPU dump, dumping all frames.");
+    s_frame_dump_interval = 1;
+    s_frames_to_run = static_cast<u32>(System::GetGPUDumpFrameCount());
+  }
+
   if (s_frame_dump_interval > 0)
   {
     if (s_dump_base_directory.empty())