diff --git a/Source/Core/DolphinQt/Debugger/MemoryViewWidget.cpp b/Source/Core/DolphinQt/Debugger/MemoryViewWidget.cpp
index 2cd85627b2..9977f3f38b 100644
--- a/Source/Core/DolphinQt/Debugger/MemoryViewWidget.cpp
+++ b/Source/Core/DolphinQt/Debugger/MemoryViewWidget.cpp
@@ -29,8 +29,10 @@
 #include "Core/Core.h"
 #include "Core/HW/AddressSpace.h"
 #include "Core/PowerPC/BreakPoints.h"
+#include "Core/PowerPC/PPCSymbolDB.h"
 #include "Core/PowerPC/PowerPC.h"
 #include "Core/System.h"
+#include "DolphinQt/Debugger/EditSymbolDialog.h"
 #include "DolphinQt/Host.h"
 #include "DolphinQt/Resources.h"
 #include "DolphinQt/Settings.h"
@@ -196,7 +198,7 @@ private:
 };
 
 MemoryViewWidget::MemoryViewWidget(Core::System& system, QWidget* parent)
-    : QWidget(parent), m_system(system)
+    : QWidget(parent), m_system(system), m_ppc_symbol_db(m_system.GetPPCSymbolDB())
 {
   auto* layout = new QHBoxLayout();
   layout->setContentsMargins(0, 0, 0, 0);
@@ -220,6 +222,8 @@ MemoryViewWidget::MemoryViewWidget(Core::System& system, QWidget* parent)
   this->setLayout(layout);
 
   connect(&Settings::Instance(), &Settings::DebugFontChanged, this, &MemoryViewWidget::UpdateFont);
+  connect(Host::GetInstance(), &Host::PPCSymbolsChanged, this,
+          [this] { UpdateDispatcher(UpdateType::Symbols); });
   connect(Host::GetInstance(), &Host::PPCBreakpointsChanged, this,
           &MemoryViewWidget::UpdateBreakpointTags);
   connect(&Settings::Instance(), &Settings::EmulationStateChanged, this, [this] {
@@ -347,6 +351,9 @@ void MemoryViewWidget::UpdateDispatcher(UpdateType type)
     if (Core::GetState(m_system) == Core::State::Paused)
       GetValues();
     UpdateColumns();
+    [[fallthrough]];
+  case UpdateType::Symbols:
+    UpdateSymbols();
     break;
   case UpdateType::Auto:
     // Values were captured on CPU thread while doing a callback.
@@ -371,7 +378,7 @@ void MemoryViewWidget::CreateTable()
   // Span is the number of unique memory values covered in one row.
   const int data_span = m_bytes_per_row / GetTypeSize(m_type);
   m_data_columns = m_dual_view ? data_span * 2 : data_span;
-  const int total_columns = MISC_COLUMNS + m_data_columns;
+  const int total_columns = MISC_COLUMNS + m_data_columns + (m_show_symbols ? 1 : 0);
 
   const int rows =
       std::round((m_table->height() / static_cast<float>(m_table->rowHeight(0))) - 0.25);
@@ -440,6 +447,15 @@ void MemoryViewWidget::CreateTable()
 
       m_table->setItem(i, c + MISC_COLUMNS, item.clone());
     }
+
+    if (!m_show_symbols)
+      continue;
+
+    // Symbols
+    auto* description_item = new QTableWidgetItem(QStringLiteral("-"));
+    description_item->setFlags(Qt::ItemIsEnabled);
+
+    m_table->setItem(i, m_table->columnCount() - 1, description_item);
   }
 
   // Update column width
@@ -500,6 +516,9 @@ void MemoryViewWidget::Update()
       item->setBackground(Qt::transparent);
       item->setData(USER_ROLE_VALID_ADDRESS, false);
     }
+
+    if (m_show_symbols)
+      m_table->item(i, m_table->columnCount() - 1)->setData(USER_ROLE_CELL_ADDRESS, row_address);
   }
 
   UpdateBreakpointTags();
@@ -576,6 +595,34 @@ void MemoryViewWidget::UpdateColumns()
   }
 }
 
+void MemoryViewWidget::UpdateSymbols()
+{
+  if (!m_show_symbols)
+    return;
+
+  // Update symbols
+  for (int i = 0; i < m_table->rowCount(); i++)
+  {
+    auto* item = m_table->item(i, m_table->columnCount() - 1);
+    if (!item)
+      continue;
+
+    const u32 address = item->data(USER_ROLE_CELL_ADDRESS).toUInt();
+    const Common::Note* note = m_ppc_symbol_db.GetNoteFromAddr(address);
+
+    std::string desc;
+    if (note == nullptr)
+      desc = m_ppc_symbol_db.GetDescription(address);
+    else
+      desc = note->name;
+
+    item->setText(QString::fromStdString(" " + desc));
+  }
+
+  if (m_show_symbols)
+    m_table->resizeColumnToContents(m_table->columnCount() - 1);
+}
+
 // Always runs on CPU thread from a callback.
 void MemoryViewWidget::UpdateOnFrameEnd()
 {
@@ -1059,6 +1106,78 @@ void MemoryViewWidget::OnCopyHex(u32 addr)
       QStringLiteral("%1").arg(value, sizeof(u64) * 2, 16, QLatin1Char('0')).left(length * 2));
 }
 
+void MemoryViewWidget::ShowSymbols(bool enable)
+{
+  m_show_symbols = enable;
+  UpdateDispatcher(UpdateType::Full);
+}
+
+void MemoryViewWidget::OnEditSymbol(EditSymbolType type, u32 addr)
+{
+  // Add Note and Add Region use these values.
+  std::string name = "";
+  std::string object_name = "";
+  u32 size = GetTypeSize(m_type);
+  u32 address = addr;
+  EditSymbolDialog::Type dialog_type = EditSymbolDialog::Type::Note;
+
+  // Add and edit region are tied to the same context menu action.
+  if (type == EditSymbolType::EditRegion)
+  {
+    // If symbol doesn't exist, it's safe to add a new region.
+    const Common::Symbol* const symbol = m_ppc_symbol_db.GetSymbolFromAddr(addr);
+    dialog_type = EditSymbolDialog::Type::Symbol;
+
+    if (symbol != nullptr)
+    {
+      // Leave the more specialized function editing to code widget.
+      if (symbol->type != Common::Symbol::Type::Data)
+        return;
+
+      // Edit data region.
+      name = symbol->name;
+      object_name = symbol->object_name;
+      size = symbol->size;
+      address = symbol->address;
+    }
+  }
+  else if (type == EditSymbolType::EditNote)
+  {
+    const Common::Note* note = m_ppc_symbol_db.GetNoteFromAddr(addr);
+    if (note == nullptr)
+      return;
+
+    name = note->name;
+    size = note->size;
+    address = note->address;
+  }
+
+  EditSymbolDialog dialog(this, address, &size, &name, dialog_type);
+
+  if (dialog.exec() != QDialog::Accepted)
+    return;
+
+  if (dialog.DeleteRequested())
+  {
+    if (type == EditSymbolType::EditRegion)
+      m_ppc_symbol_db.DeleteFunction(address);
+    else
+      m_ppc_symbol_db.DeleteNote(address);
+  }
+  else if (type == EditSymbolType::EditRegion)
+  {
+    m_ppc_symbol_db.AddKnownSymbol(Core::CPUThreadGuard{m_system}, address, size, name, object_name,
+                                   Common::Symbol::Type::Data);
+  }
+  else
+  {
+    m_ppc_symbol_db.AddKnownNote(address, size, name);
+    m_ppc_symbol_db.DetermineNoteLayers();
+  }
+
+  emit Host::GetInstance()->PPCSymbolsChanged();
+}
+
 void MemoryViewWidget::OnContextMenu(const QPoint& pos)
 {
   auto* item_selected = m_table->itemAt(pos);
@@ -1089,6 +1208,21 @@ void MemoryViewWidget::OnContextMenu(const QPoint& pos)
 
   menu->addSeparator();
 
+  auto* note_add_action = menu->addAction(
+      tr("Add Note"), this, [this, addr] { OnEditSymbol(EditSymbolType::AddNote, addr); });
+  auto* note_edit_action = menu->addAction(
+      tr("Edit Note"), this, [this, addr] { OnEditSymbol(EditSymbolType::EditNote, addr); });
+  menu->addAction(tr("Add or edit region label"), this,
+                  [this, addr] { OnEditSymbol(EditSymbolType::EditRegion, addr); });
+
+  auto* note = m_ppc_symbol_db.GetNoteFromAddr(addr);
+  note_edit_action->setEnabled(note != nullptr);
+  // A note cannot be added ontop of the starting address of another note.
+  if (note != nullptr && note->address == addr)
+    note_add_action->setEnabled(false);
+
+  menu->addSeparator();
+
   menu->addAction(tr("Show in code"), this, [this, addr] { emit ShowCode(addr); });
 
   menu->addSeparator();
diff --git a/Source/Core/DolphinQt/Debugger/MemoryViewWidget.h b/Source/Core/DolphinQt/Debugger/MemoryViewWidget.h
index 46643e39a4..102d6e0aed 100644
--- a/Source/Core/DolphinQt/Debugger/MemoryViewWidget.h
+++ b/Source/Core/DolphinQt/Debugger/MemoryViewWidget.h
@@ -24,6 +24,8 @@ class CPUThreadGuard;
 class System;
 }  // namespace Core
 
+class PPCSymbolDB;
+
 // Captures direct editing of the table.
 class TableEditDelegate : public QStyledItemDelegate
 {
@@ -76,14 +78,23 @@ public:
     Full,
     Addresses,
     Values,
+    Symbols,
     Auto,
   };
 
+  enum class EditSymbolType
+  {
+    AddNote,
+    EditNote,
+    EditRegion,
+  };
+
   explicit MemoryViewWidget(Core::System& system, QWidget* parent = nullptr);
 
   void CreateTable();
   void UpdateDispatcher(UpdateType type = UpdateType::Addresses);
   void Update();
+  void UpdateSymbols();
   void UpdateOnFrameEnd();
   void GetValues();
   void UpdateFont(const QFont& font);
@@ -98,6 +109,7 @@ public:
   void SetBPType(BPType type);
   void SetAddress(u32 address);
   void SetFocus() const;
+  void ShowSymbols(bool enable);
 
   void SetBPLoggingEnabled(bool enabled);
 
@@ -108,6 +120,7 @@ signals:
   void ActivateSearch();
 
 private:
+  void OnEditSymbol(EditSymbolType type, u32 addr);
   void OnContextMenu(const QPoint& pos);
   void OnCopyAddress(u32 addr);
   void OnCopyHex(u32 addr);
@@ -116,9 +129,11 @@ private:
   void UpdateColumns();
   void ScrollbarActionTriggered(int action);
   void ScrollbarSliderReleased();
+
   std::optional<QString> ValueToString(const Core::CPUThreadGuard& guard, u32 address, Type type);
 
   Core::System& m_system;
+  PPCSymbolDB& m_ppc_symbol_db;
 
   MemoryViewTable* m_table;
   QScrollBar* m_scrollbar;
@@ -137,6 +152,7 @@ private:
   int m_alignment = 16;
   int m_data_columns;
   bool m_dual_view = false;
+  bool m_show_symbols = true;
   std::mutex m_updating;
   QColor m_highlight_color = QColor(120, 255, 255, 100);
 
diff --git a/Source/Core/DolphinQt/Debugger/MemoryWidget.cpp b/Source/Core/DolphinQt/Debugger/MemoryWidget.cpp
index 50ecbf5dd9..7e68df9c7a 100644
--- a/Source/Core/DolphinQt/Debugger/MemoryWidget.cpp
+++ b/Source/Core/DolphinQt/Debugger/MemoryWidget.cpp
@@ -17,6 +17,7 @@
 #include <QHBoxLayout>
 #include <QLabel>
 #include <QLineEdit>
+#include <QListWidget>
 #include <QMenuBar>
 #include <QPushButton>
 #include <QRegularExpression>
@@ -32,6 +33,7 @@
 #include "Core/ConfigManager.h"
 #include "Core/Core.h"
 #include "Core/HW/AddressSpace.h"
+#include "Core/PowerPC/PPCSymbolDB.h"
 #include "Core/System.h"
 #include "DolphinQt/Debugger/MemoryViewWidget.h"
 #include "DolphinQt/Host.h"
@@ -41,7 +43,7 @@
 using Type = MemoryViewWidget::Type;
 
 MemoryWidget::MemoryWidget(Core::System& system, QWidget* parent)
-    : QDockWidget(parent), m_system(system)
+    : QDockWidget(parent), m_system(system), m_ppc_symbol_db(system.GetPPCSymbolDB())
 {
   setWindowTitle(tr("Memory"));
   setObjectName(QStringLiteral("memory"));
@@ -247,6 +249,25 @@ void MemoryWidget::CreateWidgets()
   bp_layout->addWidget(m_bp_log_check);
   bp_layout->setSpacing(1);
 
+  // Notes
+  m_labels_group = new QGroupBox(tr("Labels"));
+  auto* symbols_box = new QTabWidget;
+  m_note_list = new QListWidget;
+  m_data_list = new QListWidget;
+  m_symbols_list = new QListWidget;
+  symbols_box->addTab(m_note_list, tr("Notes"));
+  symbols_box->addTab(m_data_list, tr("Data"));
+  symbols_box->addTab(m_symbols_list, tr("Symbols"));
+  m_symbols_list->setHorizontalScrollBarPolicy(Qt::ScrollBarAlwaysOff);
+
+  auto* labels_layout = new QVBoxLayout;
+  m_search_labels = new QLineEdit;
+  m_search_labels->setPlaceholderText(tr("Filter Label List"));
+
+  m_labels_group->setLayout(labels_layout);
+  labels_layout->addWidget(symbols_box);
+  labels_layout->addWidget(m_search_labels);
+
   // Sidebar
   auto* sidebar = new QWidget;
   auto* sidebar_layout = new QVBoxLayout;
@@ -262,8 +283,9 @@ void MemoryWidget::CreateWidgets()
                          &MemoryWidget::OnSetValueFromFile);
   menubar->addMenu(menu_import);
 
+  // View Menu
   auto* auto_update_action =
-      menu_views->addAction(tr("Auto update memory values"), this, [this](bool checked) {
+      menu_views->addAction(tr("&Auto update memory values"), this, [this](bool checked) {
         m_auto_update_enabled = checked;
         if (checked)
           RegisterAfterFrameEventCallback();
@@ -274,14 +296,23 @@ void MemoryWidget::CreateWidgets()
   auto_update_action->setChecked(true);
 
   auto* highlight_update_action =
-      menu_views->addAction(tr("Highlight recently changed values"), this,
+      menu_views->addAction(tr("&Highlight recently changed values"), this,
                             [this](bool checked) { m_memory_view->ToggleHighlights(checked); });
   highlight_update_action->setCheckable(true);
   highlight_update_action->setChecked(true);
 
-  menu_views->addAction(tr("Highlight color"), this,
+  menu_views->addAction(tr("Highlight &color"), this,
                         [this] { m_memory_view->SetHighlightColor(); });
 
+  auto* show_notes =
+      menu_views->addAction(tr("&Show symbols and notes"), this, [this](bool checked) {
+        m_labels_visible = checked;
+        m_memory_view->ShowSymbols(checked);
+        UpdateNotes();
+      });
+  show_notes->setCheckable(true);
+  show_notes->setChecked(true);
+
   QMenu* menu_export = new QMenu(tr("&Export"), menubar);
   menu_export->addAction(tr("Dump &MRAM"), this, &MemoryWidget::OnDumpMRAM);
   menu_export->addAction(tr("Dump &ExRAM"), this, &MemoryWidget::OnDumpExRAM);
@@ -306,6 +337,7 @@ void MemoryWidget::CreateWidgets()
   sidebar_layout->addWidget(address_space_group);
   sidebar_layout->addItem(new QSpacerItem(1, 10));
   sidebar_layout->addWidget(bp_group);
+  sidebar_layout->addWidget(m_labels_group);
   sidebar_layout->addItem(new QSpacerItem(0, 0, QSizePolicy::Expanding, QSizePolicy::Expanding));
 
   // Splitter
@@ -327,6 +359,7 @@ void MemoryWidget::CreateWidgets()
   auto* widget = new QWidget;
   widget->setLayout(layout);
   setWidget(widget);
+  UpdateNotes();
 }
 
 void MemoryWidget::ConnectWidgets()
@@ -359,6 +392,12 @@ void MemoryWidget::ConnectWidgets()
 
   connect(m_base_check, &QCheckBox::toggled, this, &MemoryWidget::ValidateAndPreviewInputValue);
   connect(m_bp_log_check, &QCheckBox::toggled, this, &MemoryWidget::OnBPLogChanged);
+
+  for (auto* list : {m_symbols_list, m_data_list, m_note_list})
+    connect(list, &QListWidget::itemClicked, this, &MemoryWidget::OnSelectLabel);
+
+  connect(Host::GetInstance(), &Host::PPCSymbolsChanged, this, &MemoryWidget::RefreshLabelBox);
+  connect(m_search_labels, &QLineEdit::textChanged, this, &MemoryWidget::RefreshLabelBox);
   connect(m_memory_view, &MemoryViewWidget::ShowCode, this, &MemoryWidget::ShowCode);
   connect(m_memory_view, &MemoryViewWidget::RequestWatch, this, &MemoryWidget::RequestWatch);
   connect(m_memory_view, &MemoryViewWidget::ActivateSearch, this,
@@ -795,6 +834,100 @@ void MemoryWidget::OnSetValueFromFile()
   Update();
 }
 
+void MemoryWidget::RefreshLabelBox()
+{
+  if (!m_labels_visible || (m_ppc_symbol_db.Notes().empty() && m_ppc_symbol_db.IsEmpty()))
+  {
+    m_labels_group->hide();
+    return;
+  }
+
+  m_labels_group->show();
+
+  UpdateSymbols();
+  UpdateNotes();
+}
+
+void MemoryWidget::OnSelectLabel()
+{
+  QList<QListWidgetItem*> items;
+  if (m_note_list->isVisible())
+    items = m_note_list->selectedItems();
+  else if (m_symbols_list->isVisible())
+    items = m_symbols_list->selectedItems();
+  else if (m_data_list->isVisible())
+    items = m_data_list->selectedItems();
+
+  if (items.isEmpty())
+    return;
+
+  const u32 address = items[0]->data(Qt::UserRole).toUInt();
+
+  SetAddress(address);
+}
+
+void MemoryWidget::UpdateSymbols()
+{
+  const QString selection = m_symbols_list->selectedItems().isEmpty() ?
+                                QString{} :
+                                m_symbols_list->selectedItems()[0]->text();
+  m_symbols_list->clear();
+  m_data_list->clear();
+
+  for (const auto& symbol : m_ppc_symbol_db.Symbols())
+  {
+    QString name = QString::fromStdString(symbol.second.name);
+
+    // If the symbol has an object name, add it to the entry name.
+    if (!symbol.second.object_name.empty())
+    {
+      name += QString::fromStdString(fmt::format(" ({})", symbol.second.object_name));
+    }
+
+    auto* item = new QListWidgetItem(name);
+    if (name == selection)
+      item->setSelected(true);
+
+    item->setData(Qt::UserRole, symbol.second.address);
+
+    if (!name.contains(m_search_labels->text(), Qt::CaseInsensitive))
+      continue;
+
+    if (symbol.second.type != Common::Symbol::Type::Function)
+      m_data_list->addItem(item);
+    else
+      m_symbols_list->addItem(item);
+  }
+
+  m_symbols_list->sortItems();
+}
+
+void MemoryWidget::UpdateNotes()
+{
+  // Save selection to re-apply.
+  const QString selection = m_note_list->selectedItems().isEmpty() ?
+                                QStringLiteral("") :
+                                m_note_list->selectedItems()[0]->text();
+  m_note_list->clear();
+
+  for (const auto& note : m_ppc_symbol_db.Notes())
+  {
+    const QString name = QString::fromStdString(note.second.name);
+
+    auto* item = new QListWidgetItem(name);
+    if (name == selection)
+      item->setSelected(true);
+
+    item->setData(Qt::UserRole, note.second.address);
+
+    // Filter notes based on the search text.
+    if (name.contains(m_search_labels->text(), Qt::CaseInsensitive))
+      m_note_list->addItem(item);
+  }
+
+  m_note_list->sortItems();
+}
+
 static void DumpArray(const std::string& filename, const u8* data, size_t length)
 {
   if (!data)
diff --git a/Source/Core/DolphinQt/Debugger/MemoryWidget.h b/Source/Core/DolphinQt/Debugger/MemoryWidget.h
index 6aa1f01aa5..e1b0118844 100644
--- a/Source/Core/DolphinQt/Debugger/MemoryWidget.h
+++ b/Source/Core/DolphinQt/Debugger/MemoryWidget.h
@@ -14,8 +14,11 @@
 class MemoryViewWidget;
 class QCheckBox;
 class QComboBox;
+class QGroupBox;
+class QHideEvent;
 class QLabel;
 class QLineEdit;
+class QListWidget;
 class QPushButton;
 class QRadioButton;
 class QShowEvent;
@@ -27,6 +30,8 @@ class System;
 class CPUThreadGuard;
 }  // namespace Core
 
+class PPCSymbolDB;
+
 class MemoryWidget : public QDockWidget
 {
   Q_OBJECT
@@ -66,6 +71,11 @@ private:
   void OnSetValue();
   void OnSetValueFromFile();
 
+  void OnSelectLabel();
+  void RefreshLabelBox();
+  void UpdateSymbols();
+  void UpdateNotes();
+
   void OnDumpMRAM();
   void OnDumpExRAM();
   void OnDumpARAM();
@@ -85,6 +95,7 @@ private:
   void ActivateSearchAddress();
 
   Core::System& m_system;
+  PPCSymbolDB& m_ppc_symbol_db;
 
   MemoryViewWidget* m_memory_view;
   QSplitter* m_splitter;
@@ -115,6 +126,15 @@ private:
   QRadioButton* m_bp_read_only;
   QRadioButton* m_bp_write_only;
   QCheckBox* m_bp_log_check;
+
+  QGroupBox* m_labels_group;
+  QLineEdit* m_search_labels;
+  QListWidget* m_symbols_list;
+  QListWidget* m_data_list;
+  QListWidget* m_note_list;
+  QString m_note_filter;
+  bool m_labels_visible = true;
+
   Common::EventHook m_vi_end_field_event;
 
   bool m_auto_update_enabled = true;