diff --git a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
index 6edbffc0e9..175a659510 100644
--- a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
@@ -41,6 +41,8 @@ EnhancementsWidget::EnhancementsWidget(GraphicsWindow* parent) : m_block_save(fa
           [this](const QString& backend) { LoadSettings(); });
   connect(parent, &GraphicsWindow::UseFastTextureSamplingChanged, this,
           &EnhancementsWidget::LoadSettings);
+  connect(parent, &GraphicsWindow::UseGPUTextureDecodingChanged, this,
+          &EnhancementsWidget::LoadSettings);
 }
 
 constexpr int TEXTURE_FILTERING_DEFAULT = 0;
@@ -295,6 +297,7 @@ void EnhancementsWidget::LoadSettings()
 {
   m_block_save = true;
   m_texture_filtering_combo->setEnabled(Config::Get(Config::GFX_HACK_FAST_TEXTURE_SAMPLING));
+  m_arbitrary_mipmap_detection->setEnabled(!Config::Get(Config::GFX_ENABLE_GPU_TEXTURE_DECODING));
 
   // Anti-Aliasing
 
diff --git a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
index bc935d79e1..97673563b5 100644
--- a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
+++ b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
@@ -25,6 +25,7 @@ public:
 signals:
   void BackendChanged(const QString& backend);
   void UseFastTextureSamplingChanged();
+  void UseGPUTextureDecodingChanged();
 
 private:
   void CreateMainLayout();
diff --git a/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
index 9441966f0e..cfdfa866a4 100644
--- a/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/HacksWidget.cpp
@@ -31,6 +31,10 @@ HacksWidget::HacksWidget(GraphicsWindow* parent)
   connect(parent, &GraphicsWindow::BackendChanged, this, &HacksWidget::OnBackendChanged);
   OnBackendChanged(QString::fromStdString(Config::Get(Config::MAIN_GFX_BACKEND)));
   connect(&Settings::Instance(), &Settings::ConfigChanged, this, &HacksWidget::LoadSettings);
+  connect(m_gpu_texture_decoding, &QCheckBox::toggled, [this, parent] {
+    SaveSettings();
+    emit parent->UseGPUTextureDecodingChanged();
+  });
 }
 
 void HacksWidget::CreateWidgets()
@@ -264,8 +268,8 @@ void HacksWidget::AddDescriptions()
   static const char TR_GPU_DECODING_DESCRIPTION[] = QT_TR_NOOP(
       "Enables texture decoding using the GPU instead of the CPU.<br><br>This may result in "
       "performance gains in some scenarios, or on systems where the CPU is the "
-      "bottleneck.<br><br><dolphin_emphasis>If unsure, leave this "
-      "unchecked.</dolphin_emphasis>");
+      "bottleneck.<br><br>This option is incompatible with Arbitrary Mipmap Detection.<br><br>"
+      "<dolphin_emphasis>If unsure, leave this unchecked.</dolphin_emphasis>");
   static const char TR_FAST_DEPTH_CALC_DESCRIPTION[] = QT_TR_NOOP(
       "Uses a less accurate algorithm to calculate depth values.<br><br>Causes issues in a few "
       "games, but can result in a decent speed increase depending on the game and/or "