diff --git a/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
index 32b24440b6..afdedc3ea0 100644
--- a/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/AdvancedWidget.cpp
@@ -36,6 +36,10 @@ AdvancedWidget::AdvancedWidget(GraphicsWindow* parent)
   connect(&Settings::Instance(), &Settings::EmulationStateChanged, this, [this](Core::State state) {
     OnEmulationStateChanged(state != Core::State::Uninitialized);
   });
+  connect(m_manual_texture_sampling, &QCheckBox::toggled, [this, parent] {
+    SaveSettings();
+    emit parent->UseFastTextureSamplingChanged();
+  });
 
   OnBackendChanged();
   OnEmulationStateChanged(Core::GetState() != Core::State::Uninitialized);
diff --git a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
index f181780749..6edbffc0e9 100644
--- a/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/EnhancementsWidget.cpp
@@ -39,6 +39,8 @@ EnhancementsWidget::EnhancementsWidget(GraphicsWindow* parent) : m_block_save(fa
   AddDescriptions();
   connect(parent, &GraphicsWindow::BackendChanged,
           [this](const QString& backend) { LoadSettings(); });
+  connect(parent, &GraphicsWindow::UseFastTextureSamplingChanged, this,
+          &EnhancementsWidget::LoadSettings);
 }
 
 constexpr int TEXTURE_FILTERING_DEFAULT = 0;
@@ -292,6 +294,8 @@ void EnhancementsWidget::LoadPPShaders()
 void EnhancementsWidget::LoadSettings()
 {
   m_block_save = true;
+  m_texture_filtering_combo->setEnabled(Config::Get(Config::GFX_HACK_FAST_TEXTURE_SAMPLING));
+
   // Anti-Aliasing
 
   const u32 aa_selection = Config::Get(Config::GFX_MSAA);
@@ -488,7 +492,8 @@ void EnhancementsWidget::AddDescriptions()
       "that are at oblique viewing angles. Force Nearest and Force Linear override the texture "
       "scaling filter selected by the game.<br><br>Any option except 'Default' will alter the look "
       "of the game's textures and might cause issues in a small number of "
-      "games.<br><br><dolphin_emphasis>If unsure, select 'Default'.</dolphin_emphasis>");
+      "games.<br><br>This option is incompatible with Manual Texture Sampling.<br><br>"
+      "<dolphin_emphasis>If unsure, select 'Default'.</dolphin_emphasis>");
   static const char TR_OUTPUT_RESAMPLING_DESCRIPTION[] =
       QT_TR_NOOP("Affects how the game output is scaled to the window resolution."
                  "<br>The performance mostly depends on the number of samples each method uses."
diff --git a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
index 5949a2dda3..bc935d79e1 100644
--- a/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
+++ b/Source/Core/DolphinQt/Config/Graphics/GraphicsWindow.h
@@ -24,6 +24,7 @@ public:
 
 signals:
   void BackendChanged(const QString& backend);
+  void UseFastTextureSamplingChanged();
 
 private:
   void CreateMainLayout();