diff --git a/Source/Core/Core/PowerPC/Jit64/Jit_Integer.cpp b/Source/Core/Core/PowerPC/Jit64/Jit_Integer.cpp
index 6a37e9bd29..0909559f7f 100644
--- a/Source/Core/Core/PowerPC/Jit64/Jit_Integer.cpp
+++ b/Source/Core/Core/PowerPC/Jit64/Jit_Integer.cpp
@@ -1997,6 +1997,8 @@ void Jit64::twx(UGeckoInstruction inst)
 
 	s32 a = inst.RA;
 
+	gpr.KillImmediate(a, true, false);
+
 	if (inst.OPCD == 3) // twi
 		CMP(32, gpr.R(a), gpr.R(inst.RB));
 	else // tw