diff --git a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/model/BooleanSetting.kt b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/model/BooleanSetting.kt
index 298f2ebe24..5ccc6b4aad 100644
--- a/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/model/BooleanSetting.kt
+++ b/Source/Android/app/src/main/java/org/dolphinemu/dolphinemu/features/settings/model/BooleanSetting.kt
@@ -902,7 +902,6 @@ enum class BooleanSetting(
             MAIN_OVERRIDE_REGION_SETTINGS,
             MAIN_MMU,
             MAIN_PAUSE_ON_PANIC,
-            MAIN_ACCURATE_CPU_CACHE,
             MAIN_RAM_OVERRIDE_ENABLE,
             MAIN_CUSTOM_RTC_ENABLE,
             MAIN_DSP_JIT,
diff --git a/Source/Core/Core/PowerPC/PowerPC.cpp b/Source/Core/Core/PowerPC/PowerPC.cpp
index d5bd82ecd2..335658f532 100644
--- a/Source/Core/Core/PowerPC/PowerPC.cpp
+++ b/Source/Core/Core/PowerPC/PowerPC.cpp
@@ -18,6 +18,7 @@
 #include "Common/FloatUtils.h"
 #include "Common/Logging/Log.h"
 
+#include "Core/CPUThreadConfigCallback.h"
 #include "Core/Config/MainSettings.h"
 #include "Core/ConfigManager.h"
 #include "Core/Core.h"
@@ -262,8 +263,25 @@ CPUCore DefaultCPUCore()
 #endif
 }
 
+void PowerPCManager::RefreshConfig()
+{
+  const bool old_enable_dcache = m_ppc_state.m_enable_dcache;
+
+  m_ppc_state.m_enable_dcache = Config::Get(Config::MAIN_ACCURATE_CPU_CACHE);
+
+  if (old_enable_dcache && !m_ppc_state.m_enable_dcache)
+  {
+    INFO_LOG_FMT(POWERPC, "Flushing data cache");
+    m_ppc_state.dCache.FlushAll();
+  }
+}
+
 void PowerPCManager::Init(CPUCore cpu_core)
 {
+  m_registered_config_callback_id =
+      CPUThreadConfigCallback::AddConfigChangedCallback([this] { RefreshConfig(); });
+  RefreshConfig();
+
   m_invalidate_cache_thread_safe =
       m_system.GetCoreTiming().RegisterEvent("invalidateEmulatedCache", InvalidateCacheThreadSafe);
 
@@ -273,8 +291,6 @@ void PowerPCManager::Init(CPUCore cpu_core)
   m_ppc_state.iCache.Init();
   m_ppc_state.dCache.Init();
 
-  m_ppc_state.m_enable_dcache = Config::Get(Config::MAIN_ACCURATE_CPU_CACHE);
-
   if (Config::Get(Config::MAIN_ENABLE_DEBUGGING))
     m_breakpoints.ClearAllTemporary();
 }
@@ -307,6 +323,7 @@ void PowerPCManager::ScheduleInvalidateCacheThreadSafe(u32 address)
 
 void PowerPCManager::Shutdown()
 {
+  CPUThreadConfigCallback::RemoveConfigChangedCallback(m_registered_config_callback_id);
   InjectExternalCPUCore(nullptr);
   m_system.GetJitInterface().Shutdown();
   m_system.GetInterpreter().Shutdown();
diff --git a/Source/Core/Core/PowerPC/PowerPC.h b/Source/Core/Core/PowerPC/PowerPC.h
index 30cbd47b41..7612018a93 100644
--- a/Source/Core/Core/PowerPC/PowerPC.h
+++ b/Source/Core/Core/PowerPC/PowerPC.h
@@ -13,6 +13,7 @@
 
 #include "Common/CommonTypes.h"
 
+#include "Core/CPUThreadConfigCallback.h"
 #include "Core/Debugger/PPCDebugInterface.h"
 #include "Core/PowerPC/BreakPoints.h"
 #include "Core/PowerPC/ConditionRegister.h"
@@ -297,6 +298,7 @@ private:
   void InitializeCPUCore(CPUCore cpu_core);
   void ApplyMode();
   void ResetRegisters();
+  void RefreshConfig();
 
   PowerPCState m_ppc_state;
 
@@ -308,6 +310,8 @@ private:
   MemChecks m_memchecks;
   PPCDebugInterface m_debug_interface;
 
+  CPUThreadConfigCallback::ConfigChangedCallbackID m_registered_config_callback_id;
+
   CoreTiming::EventType* m_invalidate_cache_thread_safe = nullptr;
 
   Core::System& m_system;
diff --git a/Source/Core/DolphinQt/Settings/AdvancedPane.cpp b/Source/Core/DolphinQt/Settings/AdvancedPane.cpp
index af50a3f7e9..132ac4bf69 100644
--- a/Source/Core/DolphinQt/Settings/AdvancedPane.cpp
+++ b/Source/Core/DolphinQt/Settings/AdvancedPane.cpp
@@ -255,7 +255,6 @@ void AdvancedPane::Update()
   m_cpu_emulation_engine_combobox->setEnabled(!running);
   m_enable_mmu_checkbox->setEnabled(!running);
   m_pause_on_panic_checkbox->setEnabled(!running);
-  m_accurate_cpu_cache_checkbox->setEnabled(!running);
 
   {
     QFont bf = font();