diff --git a/Source/Core/DolphinQt2/Settings/GeneralPane.cpp b/Source/Core/DolphinQt2/Settings/GeneralPane.cpp
index 097053b9c3..3820bab34f 100644
--- a/Source/Core/DolphinQt2/Settings/GeneralPane.cpp
+++ b/Source/Core/DolphinQt2/Settings/GeneralPane.cpp
@@ -18,6 +18,7 @@
 
 #include "Core/Analytics.h"
 #include "Core/ConfigManager.h"
+#include "Core/Core.h"
 #include "Core/PowerPC/PowerPC.h"
 #include "DolphinQt2/Settings.h"
 #include "UICommon/AutoUpdate.h"
@@ -38,6 +39,9 @@ GeneralPane::GeneralPane(QWidget* parent) : QWidget(parent)
   LoadConfig();
 
   ConnectLayout();
+
+  connect(&Settings::Instance(), &Settings::EmulationStateChanged, this,
+          &GeneralPane::OnEmulationStateChanged);
 }
 
 void GeneralPane::CreateLayout()
@@ -59,6 +63,17 @@ void GeneralPane::CreateLayout()
   setLayout(m_main_layout);
 }
 
+void GeneralPane::OnEmulationStateChanged(Core::State state)
+{
+  const bool running = state != Core::State::Uninitialized;
+
+  m_checkbox_dualcore->setEnabled(!running);
+  m_checkbox_cheats->setEnabled(!running);
+  m_radio_interpreter->setEnabled(!running);
+  m_radio_cached_interpreter->setEnabled(!running);
+  m_radio_jit->setEnabled(!running);
+}
+
 void GeneralPane::ConnectLayout()
 {
   connect(m_checkbox_dualcore, &QCheckBox::toggled, this, &GeneralPane::OnSaveConfig);
diff --git a/Source/Core/DolphinQt2/Settings/GeneralPane.h b/Source/Core/DolphinQt2/Settings/GeneralPane.h
index 79b5c30677..f1bbc0ff82 100644
--- a/Source/Core/DolphinQt2/Settings/GeneralPane.h
+++ b/Source/Core/DolphinQt2/Settings/GeneralPane.h
@@ -14,6 +14,11 @@ class QRadioButton;
 class QSlider;
 class QVBoxLayout;
 
+namespace Core
+{
+enum class State;
+}
+
 class GeneralPane final : public QWidget
 {
   Q_OBJECT
@@ -29,6 +34,7 @@ private:
 
   void LoadConfig();
   void OnSaveConfig();
+  void OnEmulationStateChanged(Core::State state);
 
   // Widgets
   QVBoxLayout* m_main_layout;