diff --git a/Source/Core/Core/Core.cpp b/Source/Core/Core/Core.cpp
index 1ec847cecc..fb80eb7067 100644
--- a/Source/Core/Core/Core.cpp
+++ b/Source/Core/Core/Core.cpp
@@ -242,6 +242,9 @@ bool Init(std::unique_ptr<BootParameters> boot, const WindowSystemInfo& wsi)
 
   Host_UpdateMainFrame();  // Disable any menus or buttons at boot
 
+  // Manually reactivate the video backend in case a GameINI overrides the video backend setting.
+  VideoBackendBase::PopulateBackendInfo();
+
   // Issue any API calls which must occur on the main thread for the graphics backend.
   WindowSystemInfo prepared_wsi(wsi);
   g_video_backend->PrepareWindow(prepared_wsi);