diff --git a/Source/Core/DolphinQt/Config/VerifyWidget.cpp b/Source/Core/DolphinQt/Config/VerifyWidget.cpp
index ce221bce8f..9a2cd5a413 100644
--- a/Source/Core/DolphinQt/Config/VerifyWidget.cpp
+++ b/Source/Core/DolphinQt/Config/VerifyWidget.cpp
@@ -17,9 +17,11 @@
 #include <QVBoxLayout>
 
 #include "Common/CommonTypes.h"
+#include "Core/Core.h"
 #include "DiscIO/Volume.h"
 #include "DiscIO/VolumeVerifier.h"
 #include "DolphinQt/QtUtils/ParallelProgressDialog.h"
+#include "DolphinQt/Settings.h"
 
 VerifyWidget::VerifyWidget(std::shared_ptr<DiscIO::Volume> volume) : m_volume(std::move(volume))
 {
@@ -38,6 +40,20 @@ VerifyWidget::VerifyWidget(std::shared_ptr<DiscIO::Volume> volume) : m_volume(st
   layout->setStretchFactor(m_summary_text, 2);
 
   setLayout(layout);
+
+  connect(&Settings::Instance(), &Settings::EmulationStateChanged, this,
+          &VerifyWidget::OnEmulationStateChanged);
+
+  OnEmulationStateChanged();
+}
+
+void VerifyWidget::OnEmulationStateChanged()
+{
+  const bool running = Core::GetState() != Core::State::Uninitialized;
+
+  // Verifying a Wii game while emulation is running doesn't work correctly
+  // due to verification of a Wii game creating an instance of IOS
+  m_verify_button->setEnabled(!running);
 }
 
 void VerifyWidget::CreateWidgets()
diff --git a/Source/Core/DolphinQt/Config/VerifyWidget.h b/Source/Core/DolphinQt/Config/VerifyWidget.h
index c5c6945c4f..7462d5b5e7 100644
--- a/Source/Core/DolphinQt/Config/VerifyWidget.h
+++ b/Source/Core/DolphinQt/Config/VerifyWidget.h
@@ -27,6 +27,9 @@ class VerifyWidget final : public QWidget
 public:
   explicit VerifyWidget(std::shared_ptr<DiscIO::Volume> volume);
 
+private slots:
+  void OnEmulationStateChanged();
+
 private:
   void CreateWidgets();
   std::pair<QCheckBox*, QLineEdit*> AddHashLine(QFormLayout* layout, QString text);