diff --git a/Source/Core/Common/MemoryUtil.cpp b/Source/Core/Common/MemoryUtil.cpp
index aa284ab091..1941f8e35b 100644
--- a/Source/Core/Common/MemoryUtil.cpp
+++ b/Source/Core/Common/MemoryUtil.cpp
@@ -20,7 +20,7 @@
 #include <stdio.h>
 #include <sys/mman.h>
 #include <sys/types.h>
-#if defined __APPLE__ || defined __FreeBSD__
+#if defined __APPLE__ || defined __FreeBSD__ || defined __OpenBSD__
 #include <sys/sysctl.h>
 #else
 #include <sys/sysinfo.h>
@@ -253,7 +253,7 @@ size_t MemPhysical()
   memInfo.dwLength = sizeof(MEMORYSTATUSEX);
   GlobalMemoryStatusEx(&memInfo);
   return memInfo.ullTotalPhys;
-#elif defined __APPLE__ || defined __FreeBSD__
+#elif defined __APPLE__ || defined __FreeBSD__ || defined __OpenBSD__
   int mib[2];
   size_t physical_memory;
   mib[0] = CTL_HW;
@@ -261,6 +261,8 @@ size_t MemPhysical()
   mib[1] = HW_MEMSIZE;
 #elif defined __FreeBSD__
   mib[1] = HW_REALMEM;
+#elif defined __OpenBSD__
+  mib[1] = HW_PHYSMEM;
 #endif
   size_t length = sizeof(size_t);
   sysctl(mib, 2, &physical_memory, &length, NULL, 0);
diff --git a/Source/Core/Common/StringUtil.cpp b/Source/Core/Common/StringUtil.cpp
index ff6c6074cf..5048446682 100644
--- a/Source/Core/Common/StringUtil.cpp
+++ b/Source/Core/Common/StringUtil.cpp
@@ -28,7 +28,7 @@
 #include <locale.h>
 #endif
 
-#if !defined(_WIN32) && !defined(ANDROID)
+#if !defined(_WIN32) && !defined(ANDROID) && !defined(__OpenBSD__)
 static locale_t GetCLocale()
 {
   static locale_t c_locale = newlocale(LC_ALL_MASK, "C", nullptr);
@@ -121,11 +121,11 @@ bool CharArrayFromFormatV(char* out, int outsize, const char* format, va_list ar
     c_locale = _create_locale(LC_ALL, "C");
   writtenCount = _vsnprintf_l(out, outsize, format, c_locale, args);
 #else
-#if !defined(ANDROID)
+#if !defined(ANDROID) && !defined(__OpenBSD__)
   locale_t previousLocale = uselocale(GetCLocale());
 #endif
   writtenCount = vsnprintf(out, outsize, format, args);
-#if !defined(ANDROID)
+#if !defined(ANDROID) && !defined(__OpenBSD__)
   uselocale(previousLocale);
 #endif
 #endif
@@ -162,12 +162,12 @@ std::string StringFromFormatV(const char* format, va_list args)
   std::string temp = buf;
   delete[] buf;
 #else
-#if !defined(ANDROID)
+#if !defined(ANDROID) && !defined(__OpenBSD__)
   locale_t previousLocale = uselocale(GetCLocale());
 #endif
   if (vasprintf(&buf, format, args) < 0)
     ERROR_LOG(COMMON, "Unable to allocate memory for string");
-#if !defined(ANDROID)
+#if !defined(ANDROID) && !defined(__OpenBSD__)
   uselocale(previousLocale);
 #endif
 
diff --git a/Source/Core/Common/Thread.cpp b/Source/Core/Common/Thread.cpp
index 557cbfbef2..a03b9c2e57 100644
--- a/Source/Core/Common/Thread.cpp
+++ b/Source/Core/Common/Thread.cpp
@@ -12,7 +12,7 @@
 
 #ifdef __APPLE__
 #include <mach/mach.h>
-#elif defined BSD4_4 || defined __FreeBSD__
+#elif defined BSD4_4 || defined __FreeBSD__ || defined __OpenBSD__
 #include <pthread_np.h>
 #endif
 
@@ -132,7 +132,7 @@ void SetCurrentThreadName(const char* szThreadName)
 {
 #ifdef __APPLE__
   pthread_setname_np(szThreadName);
-#elif defined __FreeBSD__
+#elif defined __FreeBSD__ || defined __OpenBSD__
   pthread_set_name_np(pthread_self(), szThreadName);
 #else
   // linux doesn't allow to set more than 16 bytes, including \0.
diff --git a/Source/Core/Core/HW/EXI_DeviceEthernet.h b/Source/Core/Core/HW/EXI_DeviceEthernet.h
index 28b1aff389..26f0e8e28d 100644
--- a/Source/Core/Core/HW/EXI_DeviceEthernet.h
+++ b/Source/Core/Core/HW/EXI_DeviceEthernet.h
@@ -327,11 +327,12 @@ public:
   OVERLAPPED mWriteOverlapped;
   std::vector<u8> mWriteBuffer;
   bool mWritePending;
-#elif defined(__linux__) || defined(__APPLE__) || defined(__FreeBSD__)
+#elif defined(__linux__) || defined(__APPLE__) || defined(__FreeBSD__) || defined(__OpenBSD__)
   int fd;
 #endif
 
-#if defined(WIN32) || defined(__linux__) || defined(__APPLE__) || defined(__FreeBSD__)
+#if defined(WIN32) || defined(__linux__) || defined(__APPLE__) || defined(__FreeBSD__) ||          \
+    defined(__OpenBSD__)
   std::thread readThread;
   Common::Flag readEnabled;
   Common::Flag readThreadShutdown;
diff --git a/Source/Core/VideoCommon/DriverDetails.cpp b/Source/Core/VideoCommon/DriverDetails.cpp
index 46e264353f..f65f0afa3e 100644
--- a/Source/Core/VideoCommon/DriverDetails.cpp
+++ b/Source/Core/VideoCommon/DriverDetails.cpp
@@ -32,6 +32,8 @@ const u32 m_os = OS_ALL | OS_OSX;
 const u32 m_os = OS_ALL | OS_LINUX;
 #elif __FreeBSD__
 const u32 m_os = OS_ALL | OS_FREEBSD;
+#elif __OpenBSD__
+const u32 m_os = OS_ALL | OS_OPENBSD;
 #endif
 
 static Vendor m_vendor = VENDOR_UNKNOWN;
diff --git a/Source/Core/VideoCommon/DriverDetails.h b/Source/Core/VideoCommon/DriverDetails.h
index 3868eda77e..9c705694c6 100644
--- a/Source/Core/VideoCommon/DriverDetails.h
+++ b/Source/Core/VideoCommon/DriverDetails.h
@@ -17,6 +17,7 @@ enum OS
   OS_OSX = (1 << 3),
   OS_ANDROID = (1 << 4),
   OS_FREEBSD = (1 << 5),
+  OS_OPENBSD = (1 << 6),
 };
 // Enum of known vendors
 // Tegra and Nvidia are separated out due to such substantial differences